{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:35:49Z","timestamp":1785411349408,"version":"3.56.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>This study investigated prepulse inhibition (PPI), a brainstem reflex, in Parkinson's disease (PD) patients. We compared PPI impairment between patients with postural instability and gait difficulty (PD-PIGD) and tremor-dominant (PD-TD) subtypes and explored potential lateralization effects. Fifty PD patients and 35 healthy controls underwent pre-pulse stimulation of the finger followed by stimulation of the supraorbital nerve. Compared to controls, PD patients exhibited impaired PPI across various stimulation intervals, with a more pronounced effect in the PD-PIGD subgroup. Interestingly, no significant differences in PPI were observed between the left and right sides, suggesting a bilateral effect. These findings suggest that abnormal brainstem circuits, potentially involving the pontine nucleus, contribute to PPI dysfunction in PD. Furthermore, the association between impaired PPI and the PD-PIGD subtype highlights a potential link with gait disturbances. Future research could explore the utility of PPI as a biomarker for gait dysfunction and treatment response in PD.<\/jats:p>","DOI":"10.3389\/fneur.2025.1505598","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T04:10:13Z","timestamp":1746591013000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Elucidation of blink reflex characteristics in Parkinson's disease subtypes through prepulse 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