{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:05:22Z","timestamp":1753891522566,"version":"3.41.2"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071229"],"award-info":[{"award-number":["82071229"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The new-onset cerebral infarction is frequent after revascularization of moyamoya disease (MMD) in adults, serving as a major public health issue worldwide. The present study aims to construct a nomogram to predict postoperative new-onset cerebral infarction (POCI) after revascularization of adult MMD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Clinical data of 653 cases of adult MMD treated with revascularization were retrospectively analyzed. They were randomly divided into a training set (<jats:italic>n<\/jats:italic>\u202f=\u202f457) and a validation set (<jats:italic>n<\/jats:italic>\u202f=\u202f196) at a ratio of 7:3. Based on the risk factors of POCI after revascularization of adult MMD identified by logistic regression analysis and the corresponding regression coefficients, a nomogram was constructed. Its performance to predict POCI after revascularization of adult MMD was validated by calculating the area under the curve (AUC) and the decision curve analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Univariate and multivariate logistic regression analyses showed that preoperative cerebral infarction (OR 2.548, 95% CI 1.357\u20134.787; <jats:italic>p<\/jats:italic>\u202f=\u202f0.004), posterior cerebral artery anomalies (OR 2.106, 95% CI 1.157\u20133.834; <jats:italic>p<\/jats:italic>\u202f=\u202f0.015), post-transit arterial development (OR 2.983, 95% CI 1.336\u20136.661; <jats:italic>p<\/jats:italic>\u202f=\u202f0.008), pre-anesthesia mean arterial pressure\u202f&amp;gt;\u202f102.830\u202fmmHg (OR 3.329, 95% CI 1.938\u20135.721; <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001), total operating time\u202f&amp;gt;\u202f212.500\u202fmin (OR 2.256, 95% CI 1.239\u20134.140; <jats:italic>p<\/jats:italic>\u202f=\u202f0.008), preoperative fibrinogen level\u202f&amp;gt;\u202f2.750\u202fg\/L (OR 1.852, 95% CI 1.072\u20133.200; <jats:italic>p<\/jats:italic>\u202f=\u202f0.027), and mean corpuscular hemoglobin concentration (OR 1.021, 95% CI 1.001\u20131.040; <jats:italic>p<\/jats:italic>\u202f=\u202f0.038) were independent risk factors of POCI after revascularization of adult MMD. The AUC was 0.772 (95% CI 0.714\u20130.772) in the training set, and 0.718 (95% CI 0.603\u20130.833) in the validation set.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Collectively, the newly established nomogram effectively and intuitively predicts the POCI after revascularization of adult MMD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical trial registration<\/jats:title><jats:p><jats:uri>www.chictr.org<\/jats:uri>, identifier ChiCTR2400087946.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2025.1537755","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T16:55:42Z","timestamp":1737737742000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["A nomogram to predict postoperative new-onset cerebral infarction after revascularization of moyamoya disease in adults and its validation: a retrospective study"],"prefix":"10.3389","volume":"16","author":[{"given":"Zhen","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiacheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaping","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sijia","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mimi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhua","family":"Bo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2019e","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1007\/s10143-022-01748-w","article-title":"Research 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