{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T08:07:40Z","timestamp":1794211660488,"version":"4.8.0"},"reference-count":140,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Alzheimer\u2019s disease (AD) represents a degenerative condition affecting the nervous system, characterized by the absence of a definitive cause and a lack of a precise therapeutic intervention. Extensive research efforts are being conducted worldwide to enhance early detection methods for AD and to develop medications capable of effectively halting the initiation and progression of the disease during its early stages. Some current detection methods for early diagnosis are expensive and require invasive procedures. More and more evidence shows that gait is related to cognition. A deeper investigation into the intricate interplay between gait and cognition is necessary to elucidate their reciprocal influences and the temporal sequence of these interactions. In the future, it is hoped that with the results of clinical manifestations, neuroimaging, and electrophysiology, simple and objective gait analysis results can be used as an alternative biomarker for cognitive decline to diagnose dementia early.<\/jats:p><\/jats:sec><jats:sec><jats:title>Research objective<\/jats:title><jats:p>This research offers a comprehensive scoping review of the contemporary landscape of clinical gait evaluation. It delineates the pertinent concepts of gait analysis and machine learning in AD and elucidates the intricate interplay between gait patterns and cognitive status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature search was conducted within PubMed for all articles published until march 18, 2024, using a set of keywords, including \u201cmachine learning and gait \u201cand \u201cgait and Alzheimer.\u201d original articles that met the selection criteria were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and significance<\/jats:title><jats:p>A strong correlation exists between autonomous gait and cognitive attributes, necessitating further investigation into the selective interplay between gait and mental factors. Conversely, the gait information of Alzheimer\u2019s disease (AD) patients can be captured using a 3D gait analysis system. Numerous gait characteristics can be derived from this gait data, and the early identification of AD can be facilitated by applying a graph neural network-based machine learning approach.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2025.1548283","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T14:40:47Z","timestamp":1748961647000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Advances in gait research related to Alzheimer\u2019s disease"],"prefix":"10.3389","volume":"16","author":[{"given":"Shuding","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenmei","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuijing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.3969\/j.issn.1009-0126.2021.11.006","article-title":"Chinese expert consensus on gait analysis in Alzheimer's disease and Parkinson's disease","volume":"23","year":"2021","journal-title":"Chin J Geriatr Cardiovasc Dis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/alz.12328","article-title":"2021Alzheimer's disease facts and figures","volume":"17","year":"2021","journal-title":"Alzheimers Dement"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4045\/tidsskr.20.0919","article-title":"Alzheimer's disease - diagnosis and treatment","volume":"141","author":"Knapskog","year":"2021","journal-title":"Tidsskr Nor Laegeforen"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"101779","DOI":"10.1016\/j.arr.2022.101779","article-title":"Alzheimer's dementia or Alzheimer's disease - what's the difference and why should we care?","volume":"82","author":"Gibbs","year":"2022","journal-title":"Ageing Res Rev"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1146\/annurev-pathmechdis-051222-120750","article-title":"Neurodegenerative disease Tauopathies","volume":"19","author":"Creekmore","year":"2024","journal-title":"Annu Rev Pathol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA research framework: toward a biological definition of Alzheimer's disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/S0140-6736(06)69113-7","article-title":"Alzheimer's disease","volume":"368","author":"Blennow","year":"2006","journal-title":"Lancet"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimers Dement"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/nrd3115","article-title":"Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives","volume":"9","author":"Hampel","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1212\/wnl.56.9.1154","article-title":"Practice parameter: management of dementia (an evidence-based review). 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