{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:03:06Z","timestamp":1751515386778,"version":"3.41.0"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Delirium is an acute neurocognitive disorder prevalent among older adults and critically ill patients. Light therapy has garnered growing interest as a potential non-pharmacologic intervention for delirium management. This study conducted a bibliometric analysis of Web of Science Core Collection publications to systematically evaluate research progress and evolutionary trends in light therapy for delirium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Publications were retrieved from the Web of Science Core Collection. Bibliometric parameters including temporal trends, geographical distribution, institutional affiliations, journal impact, author productivity, keyword co-occurrence, and thematic clusters were analyzed using VOSviewer, R-bibliometrix package, and CiteSpace.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bibliometric analysis demonstrated a steady increase in annual publications, with the United States (US) contributing the highest output. Johns Hopkins University emerged as the most productive institution, while Yahya Shehabi and Melissa P. Knauert were identified as leading contributors. <jats:italic>Nursing in Critical Care<\/jats:italic> had the highest number of publications. Key research domains included\u201d sleep,\u201d \u201cintensive-care-unit,\u201d \u201cmechanically ventilated patients,\u201d \u201ccritically-ill patients,\u201d \u201clight,\u201d and so on.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The application of light in delirium is an evolving field, and further research is needed to build a well-established structural system to provide a scientific basis for clinical application. Future research should focus on specific populations, multifactorial interventions, and basic science research to strengthen the application of light therapy in the treatment of delirium.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2025.1549396","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T06:10:16Z","timestamp":1751436616000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Application of light in delirium: a bibliometric analysis"],"prefix":"10.3389","volume":"16","author":[{"given":"Yan","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongke","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangxiang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujuan","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"104239","DOI":"10.1016\/j.ijnurstu.2022.104239","article-title":"Comparative effectiveness of non-pharmacological interventions for preventing delirium in critically ill adults: a systematic review and network meta-analysis","volume":"131","author":"Chen","year":"2022","journal-title":"Int J Nurs Stud"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.chest.2021.03.030","article-title":"The effect of a quality improvement intervention on sleep and delirium in critically ill patients in a surgical ICU","volume":"160","author":"Tonna","year":"2021","journal-title":"Chest"},{"key":"ref3","article-title":"ICU Delirium","volume-title":"StatPearls","author":"Ali","year":"2024"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"168","DOI":"10.52964\/AMJA.0860","article-title":"Period-prevalence and risk factors for delirium in a tertiary referral ICU: a prospective cohort study","volume":"20","author":"Martinez","year":"2021","journal-title":"Acute Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1213\/ANE.0000000000004641","article-title":"American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on postoperative delirium prevention","volume":"130","author":"Hughes","year":"2020","journal-title":"Anesth Analg"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e825","DOI":"10.1097\/CCM.0000000000003299","article-title":"Clinical practice guidelines for the prevention and Management of Pain, agitation\/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU","volume":"46","author":"Devlin","year":"2018","journal-title":"Crit Care Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/s41572-020-00223-4","article-title":"Delirium","volume":"6","author":"Wilson","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.psychres.2017.12.046","article-title":"Bright light and oxygen therapies decrease delirium risk in critically ill surgical patients by targeting sleep and acid-base disturbances","volume":"261","author":"Potharajaroen","year":"2018","journal-title":"Psychiatry Res"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"567","DOI":"10.11909\/j.issn.1671-5411.2018.09.006","article-title":"Effect of dynamic light at the coronary care unit on the length of hospital stay and development of delirium: a retrospective cohort study","volume":"15","author":"Pustjens","year":"2018","journal-title":"J Geriatric Cardiol: JGC"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1007\/s00134-021-06490-3","article-title":"Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis","volume":"47","author":"Burry","year":"2021","journal-title":"Intensive Care Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S2213-2600(20)30552-X","article-title":"Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study","volume":"9","author":"Pun","year":"2021","journal-title":"Lancet Respir Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1007\/s10660-020-09410-7","article-title":"Knowledge mapping of platform research: a visual analysis using VOSviewer and citespace","volume":"22","author":"Ding","year":"2022","journal-title":"Electron Commer Res"},{"key":"ref13","first-page":"219","article-title":"Bibliometric and visualized analysis of research on major e-commerce journals using citespace","volume-title":"J. Electron. Commer. Res","author":"Mou","year":"2019"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1001\/jama.291.14.1753","article-title":"Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit","volume":"291","author":"Ely","year":"2004","journal-title":"JAMA"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1097\/CCM.0b013e3182783b72","article-title":"Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit","volume":"41","author":"Barr","year":"2013","journal-title":"Crit Care Med"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1055\/s-0040-1710572","article-title":"Prevention and management of delirium in the intensive care unit","volume":"42","author":"Mart","year":"2021","journal-title":"Semin Respir Crit Care Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1186\/cc8131","article-title":"Bench-to-bedside review: delirium in ICU patients - importance of sleep deprivation","volume":"13","author":"Weinhouse","year":"2009","journal-title":"Crit Care"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.ccc.2018.11.008","article-title":"Melatonin in critical care","volume":"35","author":"Marra","year":"2019","journal-title":"Crit Care Clin"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1093\/bja\/aes035","article-title":"Potential use of melatonin in sleep and delirium in the critically ill","volume":"108","author":"Bellapart","year":"2012","journal-title":"Br J Anaesth"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1111\/aas.13037","article-title":"Delirium and effect of circadian light in the intensive care unit: a retrospective cohort study","volume":"62","author":"Estrup","year":"2018","journal-title":"Acta Anaesthesiol Scand"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.iccn.2017.12.006","article-title":"Looking for light in the din: an examination of the circadian-disrupting properties of a medical intensive care unit","volume":"46","author":"Danielson","year":"2018","journal-title":"Intensive Crit Care Nurs"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e0286180","DOI":"10.1371\/journal.pone.0286180","article-title":"Improve sleep in critically ill patients: study protocol for a randomized controlled trial for a multi-component intervention of environment control in the ICU","volume":"18","author":"Alegria","year":"2023","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s00134-022-06656-7","article-title":"Melatonin in ICU delirium: shining light on the hormone of darkness","volume":"48","author":"Burry","year":"2022","journal-title":"Intensive Care Med"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"300060521990502","DOI":"10.1177\/0300060521990502","article-title":"Sleep and circadian rhythm disturbances in intensive care unit (ICU)-acquired delirium: a case-control study","volume":"49","author":"Sun","year":"2021","journal-title":"J Int Med Res"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/S2213-2600(16)00025-4","article-title":"Dynamic light application therapy to reduce the incidence and duration of delirium in intensive-care patients: a randomised controlled trial","volume":"4","author":"Simons","year":"2016","journal-title":"Lancet Respir Med"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"101207","DOI":"10.1016\/j.smrv.2019.08.001","article-title":"Promoting sleep and circadian health may prevent postoperative delirium: a systematic review and meta-analysis of randomized clinical trials","volume":"48","author":"Lu","year":"2019","journal-title":"Sleep Med Rev"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.jpsychires.2022.03.003","article-title":"Effect of light therapy on delirium in older patients with Alzheimer\u2019s disease-related dementia","volume":"149","author":"Zou","year":"2022","journal-title":"J Psychiatr Res"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"e182","DOI":"10.1097\/CCM.0000000000006152","article-title":"Modification in ICU design may affect delirium and circadian melatonin: a proof of concept pilot study","volume":"52","author":"Spies","year":"2024","journal-title":"Crit Care Med"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/ageing\/afac147","article-title":"The UN decade of healthy ageing: strengthening measurement for monitoring health and wellbeing of older people","volume":"51","author":"Amuthavalli Thiyagarajan","year":"2022","journal-title":"Age Ageing"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.maturitas.2020.05.018","article-title":"The World Health Organization (WHO) approach to healthy ageing","volume":"139","author":"Rudnicka","year":"2020","journal-title":"Maturitas"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/S0140-6736(13)60688-1","article-title":"Delirium in elderly people","volume":"383","author":"Inouye","year":"2014","journal-title":"Lancet (London, England)"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1001\/jamainternmed.2019.4446","article-title":"Effect of the tailored, family-involved hospital elder life program on postoperative delirium and function in older adults: a randomized clinical trial","volume":"180","author":"Wang","year":"2020","journal-title":"JAMA Intern Med"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.gerinurse.2024.02.017","article-title":"Effect of hospital elder life program on the incidence of delirium: a systematic review and meta-analysis of clinical trials","volume":"56","author":"Shen","year":"2024","journal-title":"Geriatr Nurs"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.mayocp.2020.08.049","article-title":"Predicting delirium risk using an automated Mayo delirium prediction tool: development and validation of a risk-stratification model","volume":"96","author":"Pagali","year":"2021","journal-title":"Mayo Clin Proc"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"21090","DOI":"10.1038\/s41598-023-48418-5","article-title":"Development of postoperative delirium prediction models in patients undergoing cardiovascular surgery using machine learning algorithms","volume":"13","author":"Nagata","year":"2023","journal-title":"Sci Rep"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1016\/j.jagp.2013.09.005","article-title":"Neuropathogenesis of delirium: review of current etiologic theories and common pathways","volume":"21","author":"Maldonado","year":"2013","journal-title":"American J Geriatric Psychiatry: Official J American Assoc Geriatric Psychiatry"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"e600","DOI":"10.1097\/CCM.0000000000003077","article-title":"The period 2 enhancer Nobiletin as novel therapy in murine models of circadian disruption resembling delirium","volume":"46","author":"Gile","year":"2018","journal-title":"Crit Care Med"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"3453","DOI":"10.2174\/1381612821666150706105602","article-title":"Disruption of circadian rhythms and delirium, sleep impairment and sepsis in critically ill patients. Potential therapeutic implications for increased light-dark contrast and melatonin therapy in an ICU environment","volume":"21","author":"Madrid-Navarro","year":"2015","journal-title":"Curr Pharm Des"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.joi.2017.08.007","article-title":"Bibliometrix: an R-tool for comprehensive science mapping analysis","volume":"11","author":"Aria","year":"2017","journal-title":"J Inf Secur"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1549396\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T06:10:18Z","timestamp":1751436618000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1549396\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,2]]},"references-count":39,"alternative-id":["10.3389\/fneur.2025.1549396"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2025.1549396","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,2]]}}}