{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:42:44Z","timestamp":1755218564824,"version":"3.43.0"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008126","name":"Jeju National University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008126","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Targeted temperature management (TTM) has been reported to improve outcomes in retrospective clinical studies, especially after recanalization in patients with anterior circulation stroke. However, the efficacy of TTM in managing posterior circulation stroke remains unexplored. Therefore, we investigated the clinical effects of TTM in patients with acute basilar artery occlusion who had successful revascularization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled patients with acute ischemic stroke due to basilar artery occlusion, with an initial National Institutes of Health Stroke Scale score of\u202f\u2265\u202f10, who had successful recanalization (defined as thrombolysis in cerebral ischemia grade\u202f\u2265\u202f2b). All patients underwent a TTM protocol targeting a core temperature of 36\u00b0C, supported by mechanical ventilation and at least 24\u202fh of temperature management. Clinical outcomes were compared, including favorable outcomes at 3\u202fmonths (defined as a modified Rankin Scale score of \u22643), mortality, length of intensive care unit (ICU) stay, and safety profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The TTM group (<jats:italic>n<\/jats:italic>\u202f=\u202f16) had a significantly lower rate of good clinical outcomes [2 (12.5%) vs. 12 (48.0%), <jats:italic>p<\/jats:italic>\u202f=\u202f0.045] and a significantly longer ICU stay [11.0 (8.5\u201315.0) vs. 9.0 (4.0\u201312.0), <jats:italic>p<\/jats:italic>\u202f=\u202f0.007] compared to the non-TTM group (<jats:italic>n<\/jats:italic>\u202f=\u202f25). Mortality was higher in the non-TTM group, although this difference was not statistically significant. Pneumonia occurred significantly more frequently in the TTM group than in the non-TTM group (<jats:italic>p<\/jats:italic>\u202f=\u202f0.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TTM may not improve clinical outcomes in patients with acute basilar artery occlusion after successful recanalization.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2025.1553750","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T07:41:06Z","timestamp":1754466066000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeted temperature management in patients with acute basilar artery occlusion after successful recanalization"],"prefix":"10.3389","volume":"16","author":[{"given":"Hong Jun","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul-Hoo","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay Chol","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joong-Goo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/S1474-4422(24)00369-7","article-title":"Global, regional, and national burden of stroke and its risk factors, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021","volume":"23","author":"Feigin","year":"2024","journal-title":"Lancet Neurology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1161\/STROKEAHA.122.040807","article-title":"Endovascular therapy for basilar artery occlusion","volume":"54","author":"Alemseged","year":"2023","journal-title":"Stroke"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1056\/NEJMoa2206317","article-title":"Trial of endovascular treatment of acute basilar-artery occlusion","volume":"387","author":"Tao","year":"2022","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1056\/NEJMoa2207576","article-title":"Trial of Thrombectomy 6 to 24 hours after stroke due to basilar-artery occlusion","volume":"387","author":"Jovin","year":"2022","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e45861","DOI":"10.7759\/cureus.45861","article-title":"The efficacy and safety of mechanical Thrombectomy in posterior circulation large vessel occlusion as compared to anterior circulation large vessel occlusion: A systematic review","volume":"15","author":"Patel","year":"2023","journal-title":"Cureus"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1056\/NEJMoa1310519","article-title":"Targeted temperature management at 33\u00b0C versus 36\u00b0C after cardiac arrest","volume":"369","author":"Nielsen","year":"2013","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1056\/NEJMoa1906661","article-title":"Targeted temperature management for cardiac arrest with nonshockable rhythm","volume":"381","author":"Lascarrou","year":"2019","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2283","DOI":"10.1056\/NEJMoa2100591","article-title":"Hypothermia versus Normothermia after out-of-hospital cardiac arrest","volume":"384","author":"Dankiewicz","year":"2021","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"586","DOI":"10.3390\/jcm13020586","article-title":"Targeted temperature Management for Patients with acute ischemic stroke: A literature review","volume":"13","author":"Binda","year":"2024","journal-title":"J Clin Med"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"67","DOI":"10.18700\/jnc.190100","article-title":"Targeted temperature management for ischemic stroke","volume":"12","author":"Hong","year":"2019","journal-title":"Journal of Neurocritical Care"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.1093\/brain\/awm083","article-title":"Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis","volume":"130","author":"van der Worp","year":"2007","journal-title":"Brain"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1161\/STROKEAHA.113.003143","article-title":"Therapeutic hypothermia after recanalization in patients with acute ischemic stroke","volume":"45","author":"Hong","year":"2014","journal-title":"Stroke"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1161\/01.str.24.1.35","article-title":"Classification of subtype of acute ischemic stroke. 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