{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T23:21:56Z","timestamp":1775604116319,"version":"3.50.1"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Alice in Wonderland Syndrome (AIWS) is characterized by transient distortions in visual perception\u2014alterations in size, shape, and spatial relationships\u2014typically described in migraine or encephalitis. Its occurrence in neurodegenerative conditions, particularly in dementia with Lewy bodies (DLB), remains exceedingly rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case description<\/jats:title><jats:p>This article reports a case of a 68-year-old patient with dementia with Lewy bodies (DLB; limbic-early subtype) who presented with typical DLB features alongside a brief episode of misperception\u2014reporting that his bed had \u201cshrunk.\u201d Neuroimaging revealed diffuse cortical atrophy with prominent bi-hippocampal and parietal lobe involvement, and hypoperfusion on HMPAO SPECT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first reported case of AIWS in a patient with DLB. We hypothesize that selective dysfunction of high-level visual networks\u2014particularly in the right extrastriate cortex responsible for the canonical storage of object size\u2014may lead to an agnosia of object size. This case underscores the importance of considering AIWS within the spectrum of visual disturbances in DLB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Theoretical implications<\/jats:title><jats:p>These findings provide novel insights into the neurobiology of visual cognition, aligning with Husserl\u2019s concept of the \u201cprimordial body\u201d (Urleib) and intuition. They suggest that disruptions in the integration of visual sensory inputs and canonical object properties may critically influence the conscious reconstruction of reality.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2025.1556218","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T01:08:44Z","timestamp":1743124124000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Alice in Wonderland Syndrome in dementia with Lewy bodies: a case report exploring visual cognition dysfunction"],"prefix":"10.3389","volume":"16","author":[{"given":"Alexis","family":"Demas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/s41586-023-06670-9","article-title":"Functional neuroimaging as a catalyst for 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