{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:27:59Z","timestamp":1792052879577,"version":"4.4.0"},"reference-count":119,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>Many migraine triggers, such as stress, sleep deprivation, fatigue, strenuous exercise, and fasting, are potentially linked to disturbances in brain energy metabolism, mitochondrial function, and oxidative stress. Alongside efforts to avoid modifiable factors, prophylactic migraine treatments that target brain energy metabolism have garnered increasing attention. However, the current evidence supporting the use of energy-modulating drugs in migraine treatment guidelines remains weak. This narrative review explores the relationship between energy metabolism and cortical spreading depression susceptibility, metabolic alterations in migraine (including glucose and insulin metabolism, insulin resistance, lipid metabolism, and energy metabolism imaging markers), oxidative stress and antioxidant defenses, mitochondrial dysfunction, and the role of energy metabolism-targeted medications in migraine management. Nutrients may help improve mitochondrial function, thereby alleviating brain energy metabolism deficits and oxidative stress in migraine.<\/jats:p>","DOI":"10.3389\/fneur.2025.1561000","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T20:18:42Z","timestamp":1743625122000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Energy metabolism disorders in migraine: triggers, pathways, and therapeutic repurposing"],"prefix":"10.3389","volume":"16","author":[{"given":"Wen-xiu","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao-mei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-jie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sui-yi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the global burden of disease study 2019","volume":"396","year":"2020","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1016\/S0140-6736(20)32160-7","article-title":"Migraine: epidemiology and systems of care","volume":"397","author":"Ashina","year":"2021","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/s10194-023-01659-1","article-title":"Global, regional, and national epidemiology of migraine and tension-type headache in youths and young adults aged 15-39 years from 1990 to 2019: findings from the global burden of disease study 2019","volume":"24","author":"Li","year":"2023","journal-title":"J Headache Pain"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/s41582-019-0255-4","article-title":"The metabolic face of migraine \u2014from pathophysiology to treatment","volume":"15","author":"Gross","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"3787","DOI":"10.1038\/s41598-023-28499-y","article-title":"Defining metabolic migraine with a distinct subgroup of patients with suboptimal inflammatory and metabolic markers","volume":"13","author":"Gross","year":"2023","journal-title":"Sci Rep"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/head.12725","article-title":"Migraine triggers and oxidative stress: a narrative review and synthesis","volume":"56","author":"Borkum","year":"2016","journal-title":"Headache"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"3654","DOI":"10.1007\/s00415-023-11706-1","article-title":"Migraine: from pathophysiology to treatment","volume":"270","author":"Puledda","year":"2023","journal-title":"J Neurol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1007\/s11064-021-03335-9","article-title":"Brain energy deficit as a source of oxidative stress in migraine: a molecular basis for migraine susceptibility","volume":"46","author":"Borkum","year":"2021","journal-title":"Neuroch. 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