{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:46:45Z","timestamp":1791229605783,"version":"4.1.0"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to observe the relationship between the presence of distal diffusion-weighted imaging (DWI) lesions and triglyceride-glucose (TyG) index and clinical outcome after intracerebral hemorrhage (ICH), and identify the risk factors for DWI lesions in ICH patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>ICH patients at the First Affiliated Hospital of Kunming Medical University were retrospectively collected. Demographic data, laboratory examination, and imaging data of the patients were collected. The patients were divided into two groups based on the presence or absence of distal DWI lesions as determined by magnetic resonance imaging (MRI). Multivariate logistic regression analysis was used to evaluate the risk factors for DWI lesions and clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 245 ICH patients included in this study, 46 (18.78%) had DWI lesions and 199 (81.22%) did not. We found that the occurrence probability of DWI lesions reached the maximum in the range Q2 of the TyG index. ICH patients with DWI lesions had a similar frequency of death or disability at 90\u202fdays compared with patients without DWI lesions. Multivariate logistic regression analysis showed that high fasting glucose (<jats:italic>p<\/jats:italic>\u202f=\u202f0.039) and hematoma site (<jats:italic>p<\/jats:italic>\u202f=\u202f0.048) were significant predictors of DWI lesions after ICH. The old age (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001), higher National Institutes of Health Stroke Scale (NIHSS) score (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001), and midline shift (<jats:italic>p<\/jats:italic>\u202f=\u202f0.034) were independent predictors of poor functional outcome at 3\u202fmonths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was no definitive correlation between the TyG index and distal DWI lesions in our study. The elevated high fasting glucose levels and hematoma site were significant predictors for DWI lesions after ICH.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2025.1562361","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T04:10:45Z","timestamp":1753071045000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The relationship between remote diffusion-weighted imaging lesions and the triglyceride-glucose index and clinical outcomes in patients with intracerebral hemorrhage"],"prefix":"10.3389","volume":"16","author":[{"given":"Lu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoliang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Potao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qionghua","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1161\/STROKEAHA.122.041410","article-title":"Relationships of hemoglobin concentration, ischemic lesions, and clinical outcomes in patients with intracerebral hemorrhage","volume":"54","author":"Roh","year":"2023","journal-title":"Stroke"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1161\/01.str.32.4.891","article-title":"The ICH score: a simple, reliable grading scale for intracerebral hemorrhage","volume":"32","author":"Hemphill","year":"2001","journal-title":"Stroke"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s12028-019-00747-y","article-title":"Stress-induced hyperglycemia and remote diffusion-weighted imaging lesions in primary intracerebral hemorrhage","volume":"32","author":"Ye","year":"2020","journal-title":"Neurocrit Care"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/ana.22668","article-title":"Predictors of highly prevalent brain ischemia in intracerebral hemorrhage","volume":"71","author":"Menon","year":"2012","journal-title":"Ann Neurol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1001\/jamaneurol.2020.2349","article-title":"A pooled analysis of diffusion-weighted imaging lesions in patients with acute intracerebral hemorrhage","volume":"77","author":"Murthy","year":"2020","journal-title":"JAMA Neurol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1161\/STROKEAHA.109.566257","article-title":"Acute brain infarcts after spontaneous intracerebral hemorrhage: a diffusion-weighted imaging study","volume":"41","author":"Prabhakaran","year":"2010","journal-title":"Stroke"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e105970","DOI":"10.1371\/journal.pone.0105970","article-title":"Fate of diffusion restricted lesions in acute intracerebral hemorrhage","volume":"9","author":"Tsai","year":"2014","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1161\/STROKEAHA.114.008304","article-title":"Ischemia in intracerebral hemorrhage is associated with leukoaraiosis and hematoma volume, not blood pressure reduction","volume":"46","author":"Gioia","year":"2015","journal-title":"Stroke"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1212\/WNL.0000000000003630","article-title":"Ischemic lesions, blood pressure dysregulation, and poor outcomes in intracerebral hemorrhage","volume":"88","author":"Kidwell","year":"2017","journal-title":"Neurology"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1210\/er.2018-00141","article-title":"Insulin resistance and atherosclerosis: implications for insulin-sensitizing agents","volume":"40","author":"Di Pino","year":"2019","journal-title":"Endocr Rev"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"3347","DOI":"10.1210\/jc.2010-0288","article-title":"The product of triglycerides and glucose, a simple measure of insulin sensitivity. 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