{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:48:42Z","timestamp":1793033322520,"version":"4.5.0"},"reference-count":87,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Tourette Syndrome (TS), a complex neurodevelopmental disorder, has seen a substantial increase in research activity, yet a systematic bibliometric analysis elucidating the global research landscape remains lacking. This study therefore employs bibliometric methods to comprehensively examine the evolution of TS research trends, international collaboration patterns, core contributors, and research hotspots, thereby providing a scientific foundation for future research directions and policy development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Based on the Web of Science Core Collection, a topic-based search strategy yielded 4,011 records (1960\u20132024). Bibliometric analyses were performed using R software and VOSviewer, incorporating annual publication trends, geographical distribution, journal impact metrics (impact factor and H-index), core author collaboration networks, and keyword co-occurrence mapping to assess the structure and dynamics of the research ecosystem.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The bibliometric analysis encompassed 4,011 publications involving 12,860 authors and 5,524 keywords. TS research exhibited a phased growth pattern. Psychiatry, psychology, and neurosciences &amp;amp; neurology emerged as the dominant research domains. While the United States remained the primary contributor, European countries\u2014particularly the United Kingdom, Germany, and Denmark\u2014demonstrated superior international collaboration. <jats:italic>Movement Disorders<\/jats:italic> proved the most productive journal, whereas <jats:italic>JAMA Psychiatry<\/jats:italic> held the greatest impact. Leading contributors such as Dr. James F. Leckman and institutions including Yale University showed exceptional research productivity. Over time, research themes have shifted from early emphases on genetics and neuroimaging to recent focuses on patient quality of life and precision interventions, reflecting a trend toward interdisciplinary integration and clinical translation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Tourette syndrome (TS) research has evolved from descriptive analyses to multidisciplinary integration, yet requires enhanced cross-regional collaboration and application of emerging technologies. Future efforts should prioritize elucidating gene\u2013environment interaction mechanisms, advancing AI-assisted diagnostics, and refining personalized treatment strategies. Concurrently, bridging regional research disparities through global alliances and standardized data platforms is imperative to ensure that scientific discoveries are translated into clinical and societal benefits. Study limitations regarding potential language and database biases underscore the importance of inclusive methodologies in subsequent investigations.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2025.1564511","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T04:10:58Z","timestamp":1749183058000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Global bibliometric analysis of Tourette syndrome research (1960\u20132024): trends, collaborations and emerging themes"],"prefix":"10.3389","volume":"16","author":[{"given":"Zhu","family":"Siying","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai","family":"Xiantao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Guangyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.neurol.2024.04.005","article-title":"French guidelines for the diagnosis and management of tourette syndrome","volume":"180","author":"Hartmann","year":"2024","journal-title":"Rev Neurol (Paris)"},{"key":"ref2","first-page":"275","article-title":"Obsessive-compulsive disorder, pandas, 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prevalence studies","volume":"65","author":"Robertson","year":"2008","journal-title":"J Psychosom Res"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1001\/jamapsychiatry.2014.2650","article-title":"Lifetime prevalence, age of risk, and genetic relationships of comorbid psychiatric disorders in tourette syndrome","volume":"72","author":"Hirschtritt","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.jpsychores.2008.03.007","article-title":"The prevalence and epidemiology of Gilles de la Tourette syndrome: part 2: tentative explanations for differing prevalence figures in GTS, including the possible effects of psychopathology, aetiology, cultural differences, and differing phenotypes","volume":"65","author":"Robertson","year":"2008","journal-title":"J Psychosom 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Eck","year":"2010","journal-title":"Scientometrics"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.joi.2017.08.007","article-title":"Bibliometrix: an R-tool for comprehensive science mapping analysis","volume":"11","author":"Aria","year":"2017","journal-title":"J Inf Secur"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1126404","DOI":"10.3389\/fpsyt.2023.1126404","article-title":"Global trends and hotspots in the digital therapeutics of autism spectrum disorders: a bibliometric analysis from 2002 to 2022","volume":"14","author":"Wu","year":"2023","journal-title":"Front Psychol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1098526","DOI":"10.3389\/fnins.2023.1098526","article-title":"Systematic bibliometric and visualized analysis of research hotspots and trends in attention-deficit hyperactivity disorder neuroimaging","volume":"17","author":"Deng","year":"2023","journal-title":"Front 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\u201caffective spectrum disorder\u201d","volume":"21","author":"Pope","year":"1991","journal-title":"Int J Psychiatry Med"},{"key":"ref48","first-page":"49","article-title":"Tourette\u2019s disorder coupled with infantile autism: a prospective study of two boys","volume":"42","author":"Kano","year":"1988","journal-title":"Jpn J Psychiatry Neurol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1212\/WNL.36.6.772","article-title":"Familial tourette\u2019s syndrome: report of a large pedigree and potential for linkage analysis","volume":"36","author":"Kurlan","year":"1986","journal-title":"Neurology"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1212\/WNL.38.3.472","article-title":"Tourette\u2019s syndrome in Monroe county school children","volume":"38","author":"Caine","year":"1988","journal-title":"Neurology"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0002-7138(10)60016-7","article-title":"A prevalence study of gilles de la tourette syndrome in North Dakota school-age children","volume":"25","author":"Burd","year":"1986","journal-title":"J Am Acad Child Psychiatry"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1097\/00004583-199708000-00014","article-title":"Comorbidity in adhd: implications for research, practice, and dsm-v","volume":"36","author":"Jensen","year":"1997","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/j.1469-8749.1996.tb15046.x","article-title":"Adhd, damp and other neurodevelopmental\/psychiatric disorders in 6-year-old children: epidemiology and co-morbidity","volume":"38","author":"Landgren","year":"1996","journal-title":"Dev Med Child Neurol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/00008571-199506000-00001","article-title":"Dopamine d2 receptor gene variants: association and linkage studies in 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