{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T20:56:18Z","timestamp":1778792178079,"version":"3.51.4"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Urinary incontinence (UI) is a prevalent clinical manifestation in spinal cord injury (SCI) patients, occurring in approximately 70% of these individuals. This systematic review aims to comprehensively evaluate the research evidence on electroacupuncture (EA) for UI after SCI, assess its clinical efficacy and safety, and provide a reference for clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Eight databases were searched for randomized controlled trials (RCTs) published from inception to May 20th, 2025. RCTs comparing EA (with or without conventional rehabilitation, CR) to CR alone for managing UI after SCI were included. Data were analyzed using R version 3.6.3. In accordance with PRISMA-2020 guidelines, two reviewers independently extracted data and assessed the risk of bias using the Cochrane risk of bias tool (ROB 2.0). The certainty of the evidence was graded using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) according to GRADE handbook.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 15 studies were included, comprising 1,394 patients with UI after SCI. The meta-analysis indicated that, compared to the CR group, the EA group showed a significant improvement in 24\u202fh incontinence frequency (MD\u202f=\u202f\u22121.42, 95% CI [\u22121.88, \u22120.96], <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.01), maximum urine output in 24\u202fh (MD\u202f=\u202f18.98, 95% CI [9.27, 28.69], <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.01), and single urination volume in 24\u202fh (MD\u202f=\u202f30.76, 95% CI [21.45, 40.08], <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.01). Regarding the Urodynamic outcome indices, the EA group displayed significant improvement in residual urine volume (MD\u202f=\u202f\u221220.06, 95% CI [\u221228.73, \u221211.38], <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.01), bladder volume (MD\u202f=\u202f38.86, 95% CI [19.98, 57.75], <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.01), maximum urine flow rate (Qmax) (MD\u202f=\u202f2.68, 95% CI [1.66, 3.70], <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.01), detrusor pressure (PdetQmax) (MD\u202f=\u202f\u22126.77, 95% CI [\u22129.54, \u22124.00], <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.01), and bladder compliance (BC) (MD\u202f=\u202f1.41, 95% CI [0.88, 1.93], <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.01). Trial Sequential Analysis (TSA) confirmed the superior treatment outcomes of EA compared to CR. The reported adverse events related to acupuncture were minimal and less severe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>EA exhibits considerable potential to enhance self-control of bladder function in patients with UI following SCI. However, this study has certain limitations, and higher quality randomized controlled trials are necessary to confirm these findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic review registration<\/jats:title><jats:p><jats:ext-link>https:\/\/www.crd.york.ac.uk\/prospero\/<\/jats:ext-link>, identifier CRD42024594516.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2025.1573090","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T12:34:18Z","timestamp":1758890058000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical efficacy of electroacupuncture for urinary incontinence following spinal cord injury: a meta-analysis and trial sequential 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population","volume":"21","author":"Anderson","year":"2004","journal-title":"J Neurotrauma"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1477-7525-11-13","article-title":"Health-related quality of life and economic impact of urinary incontinence due to detrusor overactivity associated with a neurologic condition: a systematic review","volume":"11","author":"Tapia","year":"2013","journal-title":"Health Qual Life Outcomes"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"968","DOI":"10.3390\/jpm12060968","article-title":"Neurogenic bladder physiology, pathogenesis, and management after spinal cord injury","volume":"12","author":"Perez","year":"2022","journal-title":"J Pers Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.ucl.2017.04.003","article-title":"Long-term complications of the neurogenic bladder","volume":"44","author":"Nseyo","year":"2017","journal-title":"Urol Clin North Am"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1080\/09593985.2022.2144561","article-title":"Successful outcome following a multimodal pelvic rehabilitation program in a woman with neurogenic bladder and bowel dysfunction: A case report","volume":"40","author":"Albayrak","year":"2024","journal-title":"Physiother Theory Pract"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.ucl.2015.05.006","article-title":"Urinary tract infection and neurogenic bladder","volume":"42","author":"McKibben","year":"2015","journal-title":"Urol Clin North Am"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/j.euf.2021.08.007","article-title":"Efficacy and safety of surgical treatments for neurogenic stress urinary incontinence in adults: a systematic review","volume":"8","author":"Musco","year":"2022","journal-title":"Eur Urol Focus"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"387","DOI":"10.23736\/S1973-9087.22.07217-3","article-title":"Management of bladder dysfunction in multiple sclerosis: a systematic review and meta-analysis of studies regarding bladder rehabilitation","volume":"58","author":"Vecchio","year":"2022","journal-title":"Eur J Phys Rehabil Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1248348","DOI":"10.3389\/fneur.2023.1248348","article-title":"Effect of acupuncture on BDNF signaling pathways in several nervous system diseases","volume":"14","author":"Miao","year":"2023","journal-title":"Front Neurol"},{"key":"ref10","first-page":"AT10337","article-title":"Meta-analysis on the recovery effect of acupuncture combined with rehabilitation therapy in spinal cord injury patients","volume":"5","author":"Su","year":"2024","journal-title":"Altern Ther Health 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Urodyn"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1097\/00042307-200307000-00004","article-title":"Recent developments in the management of detrusor overactivity","volume":"13","author":"Kumar","year":"2003","journal-title":"Curr Opin Urol"},{"key":"ref15","first-page":"3729","article-title":"Jiaji (EX-B2) electric field therapy in the treatment of neurogenic bladder urinary incontinence after Suprasacral spinal cord injury","volume":"39","author":"Kai","year":"2024","journal-title":"CJGMCM"},{"key":"ref16","first-page":"2421","article-title":"Influences of electroacupuncture at Baliao point combined with pelvic floor muscle electrical stimulation on urination, urodynamics and quality of life in patients with urinary incontinence after spinal cord injury","volume":"12","author":"Zhang","year":"2023","journal-title":"Anhui Med Pharm J"},{"key":"ref17","first-page":"328","article-title":"Clinical observation on deep Electroacupuncture at Baliao points in the treatment of neurogenic bladder after spinal cord injury","volume":"39","author":"Jia-Min","year":"2022","journal-title":"J Guangzhou Univ Tradition Chin Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"I4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"ref20","first-page":"606","article-title":"Selection of effect scale indexes in meta analysis","volume":"8","author":"Jin","year":"2007","journal-title":"Chin J Evid Based Med"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in 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incomplete spinal cord injury in 23 cases","volume":"33","author":"Feng","year":"2014","journal-title":"J Anhui Univ Chin Med"},{"key":"ref27","first-page":"57","article-title":"Analysis on the curative effect of electroacupuncture guanyuan acupoint in the treatment of spinal cord injury patients with detrusor reflex hyperfunction","volume":"33","author":"Geng","year":"2017","journal-title":"Chin Commun Doctors"},{"key":"ref28","first-page":"3804","article-title":"Clinical efficacy and mechanism of electroacupuncture combined with bladder function training in the treatment of neurogenic bladder dysfunction caused by detrusor hyperreflexia","volume":"26","author":"Liu","year":"2017","journal-title":"Modern J Integr Tradition Chin West Med"},{"key":"ref29","first-page":"646","article-title":"Clinical study on electroacupuncture treatment for urinary incontinence in spinal cord injury-induced neurogenic bladder","volume":"38","author":"Cheng","year":"2019","journal-title":"Shanghai J Acu-mox"},{"key":"ref30","first-page":"627","article-title":"Effects of electroacupuncture combined with bladder synthesis training on bladder function of patients with treating neurogenic bladder (detrusor hyperreflex type) after supraorbital spinal cord injury","volume":"39","author":"Jiang","year":"2019","journal-title":"J Hunan Univ Chin Med"},{"key":"ref31","first-page":"50","article-title":"Effect of electroacupuncture combined with modern rehabilitation technology on rehabilitation of patients with bladder urinary incontinence caused by spinal cord injury","volume":"28","author":"Hua-jing","year":"2021","journal-title":"China Mod Med"},{"key":"ref32","first-page":"136","article-title":"Effects of electroacupuncture combined with pelvic floor electromyography biofeedback on micturition diary and urodynamic indexes in patients with neurogenic bladder after spinal cord injury","volume":"6","author":"Li","year":"2021","journal-title":"Clin Res 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acupoints on urodynamics and urinary function in patients with SCI NB","volume":"26","author":"Hu","year":"2024","journal-title":"Zhejiang Clin Med"},{"key":"ref37","first-page":"160","article-title":"Effects of electroacupuncture combined with pelvic floor muscle electrical stimulation on urinary function and urodynamic parameters in patients with urinary incontinence after spinal cord injury","volume":"31","author":"Jiangeng","year":"2024","journal-title":"Capital Food Med"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1097\/JU.0000000000003985","article-title":"The AUA\/SUFU guideline on the diagnosis and treatment of idiopathic overactive bladder","volume":"212","author":"Cameron","year":"2024","journal-title":"J Urol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1007\/s00120-020-01319-1","article-title":"Die chirurgische Therapie der benignen Prostataobstruktion (BPO) beim antikoagulierten Patienten: eine \u00dcbersichtsarbeit \u00fcber die Blutungsrisiken etablierter Techniken [Surgical treatment of benign prostatic obstruction (BPO) in patients under anticoagulation: a review of the bleeding risks of established techniques]","volume":"59","author":"Deininger","year":"2020","journal-title":"Urologe A"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"17018","DOI":"10.1038\/nrdp.2017.18","article-title":"Traumatic spinal cord injury","volume":"3","author":"Ahuja","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1097\/JU.0000000000003021","article-title":"Neurogenic lower urinary tract dysfunction in the first year after spinal cord injury: A descriptive study of urodynamic findings","volume":"209","author":"Kozomara","year":"2023","journal-title":"J Urol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.2147\/JPR.S322964","article-title":"Neuropathic pain creates systemic ultrastructural changes in the nervous system corrected by Electroacupuncture but not by Pregabalin","volume":"14","author":"Gao","year":"2021","journal-title":"J Pain Res"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"111108","DOI":"10.1016\/j.brainresbull.2024.111108","article-title":"GABAB modulate NF-\u03baB\/NLRP3 pathways in electroacupuncture prevention of depression in CUMS rats","volume":"218","author":"Li","year":"2024","journal-title":"Brain Res Bull"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"ENEURO.0190-23.2023","DOI":"10.1523\/ENEURO.0190-23.2023","article-title":"Electroacupuncture relieves HuR\/KLF9-mediated inflammation to enhance neurological repair after spinal cord injury","volume":"10","author":"Zhang","year":"2023","journal-title":"eNeuro"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s12035-023-03577-4","article-title":"Effect of Electroacupuncture stimulation on proliferation and differentiation of endogenous neural stem cells in rats with spinal cord injury","volume":"61","author":"Deng","year":"2024","journal-title":"Mol Neurobiol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1089\/neu.2020.7155","article-title":"Governor vessel electro-acupuncture promotes the intrinsic growth ability of spinal neurons through activating calcitonin gene-related peptide\/\u03b1-calcium\/Calmodulin-dependent protein kinase\/Neurotrophin-3 pathway after spinal cord injury","volume":"38","author":"Xu","year":"2021","journal-title":"J Neurotrauma"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3109\/10601331003777444","article-title":"Blinding assessment in clinical trials: a review of statistical methods and a proposal of blinding assessment protocol","volume":"27","author":"Bang","year":"2010","journal-title":"Clin Res Regul Aff"}],"container-title":["Frontiers in 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