{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T02:29:06Z","timestamp":1768444146983,"version":"3.49.0"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000182","name":"U.S. Army Medical Research and Materiel Command","doi-asserted-by":"publisher","award":["W81XWH-08-2-0159"],"award-info":[{"award-number":["W81XWH-08-2-0159"]}],"id":[{"id":"10.13039\/100000182","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Many active duty service members with mild traumatic brain injury (mTBI) report comorbidities such as depression, anxiety, PTSD, insomnia, and pain. We analyzed data from a prior randomized controlled trial (RCT) to examine the effects of evidence-based treatment modules, delivered by telephone, on the number and symptom burden of five common comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and participants<\/jats:title><jats:p>356 service members from two military medical centers who had sustained deployment-related mTBI in the preceding 2\u202fyears.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Secondary analysis of RCT comparing 6\u202fmonths of telephone-delivered problem-solving treatment (PST) with comorbidity-specific modules to education only (EO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main measures<\/jats:title><jats:p>Comorbidity burden measured by Patient Health Questionnaire-9, Brief Symptom Inventory-Anxiety, PTSD Checklist, Pittsburgh Sleep Quality Inventory, Rivermead Postconcussion Symptoms Questionnaire (headache item) assessed at baseline and 6 and 12\u202fmonths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>47% of service members endorsed \u2265 3 comorbidities at baseline. At 6\u202fmonths, the PST group had significantly fewer comorbidities, greater improvement in depression, anxiety, PTSD, and sleep, but not headache, and higher response\/remission rates for depression and sleep, compared to EO. There were no significant group differences at 12\u202fmonths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Telephone-delivered PST with comorbidity-specific modules reduces burden of comorbidities after deployment-related mTBI. Research is needed on how to maintain improvements over time.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2025.1594748","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T07:44:42Z","timestamp":1753861482000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of a modular telehealth intervention on comorbid conditions in service members with mild traumatic brain injury"],"prefix":"10.3389","volume":"16","author":[{"given":"Jesse R.","family":"Fann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tessa","family":"Hart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen R.","family":"Bell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wesley","family":"Cole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rema","family":"Raman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Barber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sureyya","family":"Dikmen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murray B.","family":"Stein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Temkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"ref1","volume-title":"VA evidence-based synthesis program reports. 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