{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:36:04Z","timestamp":1788222964982,"version":"build-2803163510"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Tinnitus is a symptom often associated with hearing loss (HL). Its development and progression are still not completely clear, as the heterogeneity of tinnitus-related HL data is high. Here, we attempt to investigate whether a part of this variance can be correlated with single or combinations of non-auditory comorbidities using pure-tone audiometric data in a collective of chronic subjective tinnitus patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The information of 136 tinnitus patient files was extracted retrospectively. The patients did not suffer from any auditory impairment except a possible HL and tinnitus; non-auditory comorbidities were identified from the files and categorized by their ICD-10 category. Comorbidity classes were endocrine\/metabolic diseases, psychiatric\/behavioral disorders, diseases of the central nervous system, diseases of the circulatory system, diseases of the respiratory system, diseases of the digestive system, and muscle-skeletal diseases. The pure-tone audiometry data, as well as tinnitus pitch and loudness, were correlated with their non-auditory comorbidity classes and patients\u2019 age group using non-parametric and parametric analyses, where appropriate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Depending on the age group, the number of comorbidities could lead to a significant increase or decrease in HL. Only in older patients, a linear correlation between the number of non-auditory comorbidities and an increase in HL could be found. Moreover, the correlation between maximal HL frequency and tinnitus frequency can only be seen in specific age and comorbidity-number groups. Only some specific non-auditory comorbidity classes showed significant effects (decrease or increase) on HL in specific age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Taken together, we argue that in future tinnitus patient studies, non-auditory comorbidities should be taken into account as possible covariables that might explain the variance found in the auditory threshold development of these patients.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2025.1596274","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T14:36:45Z","timestamp":1750948605000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Correlation of non-auditory comorbidities and hearing loss in chronic subjective tinnitus patients: a retrospective database 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