{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:07:36Z","timestamp":1758701256888,"version":"3.44.0"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001391"],"award-info":[{"award-number":["82001391"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify and quantify clonic seizures in children, we retrospectively reviewed the clinical symptoms and neurophysiology of them.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were obtained from 24 patients presenting with 34 clonic seizures, and their video-electroencephalography (EEG) recordings were examined for symptomatology and ictal EEG characteristics. Additionally, synchronous electromyography (EMG) data from 17 patients were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our quantitative analysis demonstrated high diagnostic precision in lateralizing focal clonic seizures, with 90.9% exhibiting contralateral hemispheric concordance. The perirolandic region emerged as the predominant seizure-onset zone (62.85%), while paroxysmal rhythmic monomorphic activity constituted the most frequent ictal EEG pattern (72.72%). Semiological evaluation revealed preferential lower limb involvement at onset (38.23% of seizures) followed by upper limb manifestations (14.7%), with propagation patterns dominated by medial-to-lateral spread (63.63%) over purely lateral dissemination (36.36%). Neurophysiological profiling identified a mean EEG\u2013EMG discharge latency of 115.88\u202fmsec. Notably, epilepsy represented the primary underlying etiology (83.83%), distinguishing pediatric clonic seizures from adult populations where structural lesions predominate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The lateralizing value, seizure-onset zone and EEG seizure pattern in childhood clonic seizures exhibited consistency with those observed in adults. Nonetheless, distinctions were noted in the initial affected body parts, latency, and etiology compared to adult cases. The delineated characteristics in this study could facilitate the recognition and assessment of clonic seizures during video-EEG monitoring in children.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2025.1597943","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T05:34:37Z","timestamp":1755149677000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Semiology and neurophysiology of clonic seizures in children: a retrospective study"],"prefix":"10.3389","volume":"16","author":[{"given":"Qiao","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingsong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siqi","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1111\/epi.13670","article-title":"Operational classification of seizure types by the international league against epilepsy: position paper of the ILAE Commission for Classification and Terminology","volume":"58","author":"Fisher","year":"2017","journal-title":"Epilepsia"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1111\/epi.13671","article-title":"Instruction manual for the ILAE 2017 operational classification of seizure types","volume":"58","author":"Fisher","year":"2017","journal-title":"Epilepsia"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1528-1167.2009.02328.x","article-title":"Louis Fran\u00e7ois Bravais and Jacksonian epilepsy","volume":"51","author":"Eadie","year":"2010","journal-title":"Epilepsia"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1093\/brain\/101.2.307","article-title":"Somatosensory epilepsy. A review of 127 cases","volume":"101","author":"Mauguiere","year":"1978","journal-title":"Brain"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1093\/brain\/119.1.17","article-title":"An analysis of clinical seizure patterns and their localizing value in frontal and temporal lobe epilepsies","volume":"119","author":"Manford","year":"1996","journal-title":"Brain"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2160","DOI":"10.1212\/wnl.62.12.2160","article-title":"Postictal paresis in focal epilepsies--incidence, duration, and causes: a video-EEG monitoring study","volume":"62","author":"Gallmetzer","year":"2004","journal-title":"Neurology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/s0920-1211(00)00186-8","article-title":"Lateralizing value of unilateral motor and somatosensory manifestations in frontal lobe seizures","volume":"43","author":"Janszky","year":"2001","journal-title":"Epilepsy 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