{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:35:41Z","timestamp":1755225341411,"version":"3.43.0"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Although mini-open carpal tunnel release (Mini-OCTR) proves to be a standard solution for carpal tunnel syndrome (CTS), precise prediction of recovery remains challenging. The aim of this study was to explore the potential of using intraoperative change in distal motor latency (DML) to predict clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort analysis was performed on 52 primary CTS patients, who completed the questionnaires before Mini-OCTR, 1\u202fday (1\u202fday Post-op) and 6\u202fmonths after Mini-OCTR (6\u202fmonths Post-op). Latency recovery percent (LRP) was calculated to represent intraoperative change of DML after Mini-OCTR. Multivariate and simple logistic regression analyses were used to quantify the predictive value of LRP on postoperative outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results of patient-reported outcome measures (PROMs) demonstrated that Mini-OCTR was an effective procedure in treating CTS generally with some of the patients experiencing significant improvement in sensory function at 1\u202fday Post-op. Multivariate logistic regression analysis which involves demographic information, CTS-related medical history, electrodiagnostic test results, PROMs and LRP revealed that the prognostic model has high AUC and accuracy, and LRP is a significant predictor among all the involved variables. Simple logistic regression analysis identified an optimal LRP cut-off value of 0.11 for predicting sensory recovery at 1\u202fday Post-op with high accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study introduces LRP as a practical biomarker that enables surgeons to predict immediate postoperative sensory improvement in Mini-OCTR patients, which can assist surgeons in setting short-term expectations and tailoring postoperative care for the patients.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2025.1607199","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T10:06:10Z","timestamp":1755079570000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Intraoperative change in distal motor latency as a predictor for clinical outcome after mini-OCTR: a retrospective cohort study"],"prefix":"10.3389","volume":"16","author":[{"given":"Mingjie","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuxiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenpei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Liverneaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1007\/s10571-022-01297-2","article-title":"Pathophysiology, diagnosis, treatment, and genetics of carpal tunnel syndrome: a review","volume":"43","author":"Malakootian","year":"2023","journal-title":"Cell Mol Neurobiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1212\/wnl.56.11.1431","article-title":"Carpal tunnel syndrome: complex issues with a \u201csimple\u201d condition","volume":"56","author":"Olney","year":"2001","journal-title":"Neurology"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"211","DOI":"10.2106\/00004623-196648020-00001","article-title":"The carpal-tunnel syndrome. Seventeen years\u2019 experience in diagnosis and treatment of six hundred fifty-four hands","volume":"48","author":"Phalen","year":"1966","journal-title":"J Bone Joint Surg Am"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1097\/j.pain.0000000000002386","article-title":"Systemic inflammatory markers in neuropathic pain, nerve injury, and recovery","volume":"163","author":"Sandy-Hindmarch","year":"2022","journal-title":"Pain"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1097\/PRS.0000000000010773","article-title":"Subjective and objective differences in patients with unilateral and bilateral carpal tunnel syndrome and the role of obesity in syndrome severity","volume":"153","author":"Vernick","year":"2024","journal-title":"Plast Reconstr Surg"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/1756-185X.12445","article-title":"The incidence of carpal tunnel syndrome in patients with rheumatoid arthritis","volume":"18","author":"Lee","year":"2015","journal-title":"Int J Rheum Dis"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/dme.12855","article-title":"Diabetes as a risk factor for carpal tunnel syndrome: a systematic review and meta-analysis","volume":"33","author":"Pourmemari","year":"2016","journal-title":"Diabet Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.jhsa.2023.01.013","article-title":"Incidence of peripheral nerve decompression surgery during pregnancy and the first year after delivery in Finland from 1999 to 2017: a retrospective register-based cohort study","volume":"48","author":"Nyrhi","year":"2023","journal-title":"J Hand Surg Am"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s41572-024-00521-1","article-title":"Carpal tunnel syndrome","volume":"10","author":"Dahlin","year":"2024","journal-title":"Nat Rev Dis Primers"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1227\/NEU.0000000000001749","article-title":"Predicting clinically relevant patient-reported symptom improvement after carpal tunnel release: a machine learning approach","volume":"90","author":"Hoogendam","year":"2022","journal-title":"Neurosurgery"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"492","DOI":"10.3390\/diagnostics13030492","article-title":"Predicting CTS diagnosis and prognosis based on machine learning techniques","volume":"13","author":"Elseddik","year":"2023","journal-title":"Diagnostics"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"108395","DOI":"10.1016\/j.clineuro.2024.108395","article-title":"Predictors of pain intensity in carpal tunnel syndrome: development and validation of a model","volume":"243","author":"Rezaee","year":"2024","journal-title":"Clin Neurol Neurosurg"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e829","DOI":"10.1097\/PR9.0000000000000829","article-title":"Entrapment neuropathies: a contemporary approach to pathophysiology, clinical assessment, and management","volume":"5","author":"Schmid","year":"2020","journal-title":"Pain Rep"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1016\/j.clinph.2006.01.018","article-title":"Nerve excitability testing and its clinical application to neuromuscular diseases","volume":"117","author":"Nodera","year":"2006","journal-title":"Clin Neurophysiol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1111\/j.1365-2990.1986.tb00159.x","article-title":"Chronic human nerve compression--a histological assessment","volume":"12","author":"Mackinnon","year":"1986","journal-title":"Neuropathol Appl Neurobiol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/s0749-0712(01)00012-9","article-title":"Pathophysiology of nerve compression","volume":"18","author":"Mackinnon","year":"2002","journal-title":"Hand Clin"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1016\/j.jhsa.2019.06.016","article-title":"Carpal tunnel syndrome: a potential early, red-flag sign of amyloidosis","volume":"44","author":"Donnelly","year":"2019","journal-title":"J Hand Surg Am"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e001755","DOI":"10.1136\/openhrt-2021-001755","article-title":"Nationwide prevalence and characteristics of transthyretin amyloid cardiomyopathy in Sweden","volume":"8","author":"Lauppe","year":"2021","journal-title":"Open Heart"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"g6437","DOI":"10.1136\/bmj.g6437","article-title":"Carpal tunnel syndrome","volume":"349","author":"Middleton","year":"2014","journal-title":"BMJ"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.3390\/jcm10122691","article-title":"Electrodiagnostic studies in the surgical treatment of carpal tunnel syndrome-a systematic review","volume":"10","author":"Osiak","year":"2021","journal-title":"J Clin Med"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1002\/mus.22208","article-title":"Electrodiagnostic evaluation of carpal tunnel syndrome","volume":"44","author":"Werner","year":"2011","journal-title":"Muscle Nerve"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1177\/1753193416659404","article-title":"Measurement properties of the EuroQoL EQ-5D-5L to assess quality of life in patients undergoing carpal tunnel release","volume":"41","author":"Marti","year":"2016","journal-title":"J Hand Surg Eur Vol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.jhsg.2023.07.011","article-title":"Best-evidence systematic review and Meta-analysis of endoscopic carpal tunnel release outcomes","volume":"5","author":"Miller","year":"2023","journal-title":"J Hand Surg Glob Online"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1016\/j.jhsa.2014.07.017","article-title":"An outcomes protocol for carpal tunnel release: a comparison of outcomes in patients with and without medical comorbidities","volume":"39","author":"Cagle","year":"2014","journal-title":"J Hand Surg Am"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1007\/s004150200004","article-title":"Conservative treatment options for carpal tunnel syndrome: a systematic review of randomised controlled trials","volume":"249","author":"Gerritsen","year":"2002","journal-title":"J Neurol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.jhsa.2004.01.011","article-title":"Time course and predictors of median nerve conduction after carpal tunnel release","volume":"29","author":"Rotman","year":"2004","journal-title":"J Hand Surg Am"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.clineuro.2008.07.006","article-title":"Short-term electrophysiological conduction change in median nerve fibres after carpal tunnel release","volume":"110","author":"Ginanneschi","year":"2008","journal-title":"Clin Neurol Neurosurg"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1097\/WNP.0b013e3181dd4ff0","article-title":"Changes in electrophysiological parameters after surgery for the carpal tunnel syndrome","volume":"27","author":"El-Hajj","year":"2010","journal-title":"J Clin Neurophysiol"},{"key":"ref29","first-page":"e63","article-title":"Intraoperative nerve conduction studies during open carpal tunnel release: a pilot study","volume":"22","author":"Congiusta","year":"2022","journal-title":"Eplasty"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/s0363-5023(78)80119-1","article-title":"Intraoperative changes in motor nerve conduction latency in carpal tunnel syndrome","volume":"3","author":"Eversmann","year":"1978","journal-title":"J Hand Surg Am"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3109\/17453679809002363","article-title":"Self-administered outcome instrument in carpal tunnel syndrome: reliability, validity and responsiveness evaluated in 102 patients","volume":"69","author":"Atroshi","year":"1998","journal-title":"Acta Orthop Scand"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/1471-2474-7-78","article-title":"A systematic review of the psychometric properties of the Boston carpal tunnel questionnaire","volume":"7","author":"Leite","year":"2006","journal-title":"BMC Musculoskelet Disord"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1016\/j.jhsa.2018.05.017","article-title":"Predicting clinical outcome after surgical treatment in patients with carpal tunnel syndrome","volume":"43","author":"Jansen","year":"2018","journal-title":"J Hand Surg Am"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"390.e1","DOI":"10.1016\/j.jhsa.2017.02.009","article-title":"Prospective evaluation of sleep improvement following carpal tunnel release surgery","volume":"42","author":"Tulipan","year":"2017","journal-title":"J Hand Surg Am"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/s0363-5023(99)70014-6","article-title":"Symptoms, disability, and quality of life in patients with carpal tunnel syndrome","volume":"24","author":"Atroshi","year":"1999","journal-title":"J Hand Surg Am"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1177\/17531934231214661","article-title":"Diagnosis of carpal tunnel syndrome using a 10-s grip-and-release test with video and machine learning analysis","volume":"49","author":"Tsukamoto","year":"2024","journal-title":"J Hand Surg Eur Vol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"3211","DOI":"10.3390\/diagnostics13203211","article-title":"Deep learning-based approaches for enhanced diagnosis and comprehensive understanding of carpal tunnel syndrome","volume":"13","author":"Elseddik","year":"2023","journal-title":"Diagnostics"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3390\/bioengineering11020175","article-title":"Carpal tunnel syndrome automated diagnosis: a motor vs. sensory nerve conduction-based approach","volume":"11","author":"Bakalis","year":"2024","journal-title":"Bioengineering"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3390\/bioengineering8110181","article-title":"Automatic electrodiagnosis of carpal tunnel syndrome using machine learning","volume":"8","author":"Tsamis","year":"2021","journal-title":"Bioengineering"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"17464","DOI":"10.1038\/s41598-021-97043-7","article-title":"Machine learning-based approach for disease severity classification of carpal tunnel syndrome","volume":"11","author":"Park","year":"2021","journal-title":"Sci Rep"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1227\/neu.0000000000002848","article-title":"Algorithm versus expert: machine learning versus surgeon-predicted symptom improvement after carpal tunnel release","volume":"95","author":"Loos","year":"2024","journal-title":"Neurosurgery"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1002\/mus.26297","article-title":"A prognostic model for the patient-reported outcome of surgical treatment of carpal tunnel syndrome","volume":"58","author":"Bowman","year":"2018","journal-title":"Muscle Nerve"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"e0300044","DOI":"10.1371\/journal.pone.0300044","article-title":"Carpal tunnel syndrome prediction with machine learning algorithms using anthropometric and strength-based measurement","volume":"19","author":"Yeti\u015f","year":"2024","journal-title":"PLoS One"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/S1470-2045(19)30738-7","article-title":"Artificial intelligence for diagnosis and grading of prostate cancer in biopsies: a population-based, diagnostic study","volume":"21","author":"Str\u00f6m","year":"2020","journal-title":"Lancet Oncol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"6215","DOI":"10.1038\/s41467-024-50369-y","article-title":"A multi-classifier system integrated by clinico-histology-genomic analysis for predicting recurrence of papillary renal cell carcinoma","volume":"15","author":"Huang","year":"2024","journal-title":"Nat Commun"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/s41586-021-03512-4","article-title":"AI-based pathology predicts origins for cancers of unknown primary","volume":"594","author":"Lu","year":"2021","journal-title":"Nature"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1038\/s41591-018-0177-5","article-title":"Classification and mutation prediction from non-small cell lung cancer histopathology images using deep learning","volume":"24","author":"Coudray","year":"2018","journal-title":"Nat Med"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1007\/s00402-016-2514-9","article-title":"Ultrasound measurement of median nerve cross-sectional area at the inlet and outlet of carpal tunnel after carpal tunnel release compared to electrodiagnostic findings","volume":"136","author":"Inui","year":"2016","journal-title":"Arch Orthop Trauma Surg"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"e17638","DOI":"10.7759\/cureus.17638","article-title":"Residual symptoms after carpal tunnel decompression and treatment with gabapentin: a multicenter study","volume":"13","author":"Aydin","year":"2021","journal-title":"Cureus"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1081440","DOI":"10.3389\/fneur.2023.1081440","article-title":"The significance of wrist immobilization for endoscopic carpal tunnel release","volume":"14","author":"Zhang","year":"2023","journal-title":"Front Neurol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"e82529","DOI":"10.7759\/cureus.82529","article-title":"Assessment of the impact of specialized physical therapy on the clinical condition of patients after carpal tunnel release","volume":"17","author":"Georgiew","year":"2025","journal-title":"Cureus"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"321","DOI":"10.22038\/ABJS.2023.62995.3052","article-title":"WALANT technique versus local anesthesia with a tourniquet in carpal tunnel syndrome","volume":"11","author":"Gallucci","year":"2023","journal-title":"Arch Bone Jt Surg"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1607199\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T10:06:11Z","timestamp":1755079571000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1607199\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,13]]},"references-count":52,"alternative-id":["10.3389\/fneur.2025.1607199"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2025.1607199","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,13]]},"article-number":"1607199"}}