{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:17:56Z","timestamp":1793319476133,"version":"4.5.0"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>With the accelerating global population aging, the incidence rates of Alzheimer\u2019s disease and other dementias (ADOD) continue to rise sharply, presenting a pressing public health challenge worldwide. In China, where population aging is occurring at an unprecedented rate, the epidemiological trajectory of ADOD has garnered significant attention. The marked increase in incidence rates has imposed a substantial burden on both society and families, driven by direct healthcare costs, long-term care demands, and productivity losses among caregivers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study utilized the age-period-cohort model to analyze the changes in the incidence and disability-adjusted life years (DALYs) rate of ADOD among the elderly population in China from 1990 to 2021, considering the dimensions of age, period, and cohort. The necessary data for this analysis were sourced from the Global Burden of Disease (GBD) 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 1990 to 2021, the incidence, prevalence, and DALYs of ADOD have significantly risen both globally and in China, with the growth rates in China notably surpassing the global average. China\u2019s age-standardized incidence rate demonstrated an annual percent change of 0.921 (95% UI: 0.817, 1.025), with females (1.107) exhibiting a higher trend compared to males (0.695). The Average Annual Percentage Change (AAPC) for prevalence reached 5.995 (95% UI: 5.327, 6.664), significantly exceeding the global figure of 0.617. Age-effect analysis indicated that the effect coefficient for the 60\u201364 age group was 197.30, escalating dramatically to 3698.13 for the 85\u201389 age group, thus highlighting an exponential increase in risk with advancing age. The period effect peaked at 1.04 during 2018\u20132021, which is associated with accelerated aging and improvements in diagnostic techniques. In cohort analysis, the risk for individuals born between 1950 and 1954 increased compared to those born between 1895 and 1899.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>China is confronted with a dual challenge: the escalating burden of ADOD and a rapidly aging population, with female populations disproportionately affected. Urgent, gender-sensitive interventions are essential to enhance early detection, improve long-term care, and address modifiable risk factors. This study emphasizes the necessity for sustained investments in public health infrastructure and research to mitigate the increasing societal and economic impacts of ADOD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2025.1628577","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T04:10:52Z","timestamp":1751602252000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Incidence trends and age-period-cohort analysis of Alzheimer\u2019s disease and other dementias in the world and China from 1990 to 2021: analyses based on the Global Burden of Disease Study 2021"],"prefix":"10.3389","volume":"16","author":[{"given":"Xuewang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanxin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.3390\/medicina60111783","article-title":"Trends in global burden of Alzheimer's disease and other dementias attributable to high fasting plasma glucose, 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Alzheimer's disease and other types of dementia in Asia from 1990 to 2021","volume":"12","author":"Guo","year":"2025","journal-title":"J Prev Alzheimers Dis"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/S1474-4422(18)30403-4","article-title":"Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2016: a systematic analysis for the global burden of disease study 2016","volume":"18","year":"2019","journal-title":"Lancet Neurol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e0322574","DOI":"10.1371\/journal.pone.0322574","article-title":"A systematic analysis for disease burden, risk factors, and trend projection of Alzheimer\u2019s disease and other dementias in China and globally","volume":"20","author":"Liu","year":"2025","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1516267","DOI":"10.3389\/fpubh.2024.1516267","article-title":"Systematic analysis and prediction of 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