{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:38:59Z","timestamp":1790959139205,"version":"4.1.0"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Benign paroxysmal positional vertigo (BPPV) is the most common type of vertigo in clinical practice. Previous studies have suggested that inflammatory responses and metabolic disorders may be involved in the pathogenesis of BPPV, but systematic analyses based on large samples are lacking. The aim of this study is to construct an intelligent auxiliary diagnostic model for BPPV based on the big data of SRM-IV vertigo diagnostic and treatment system, and to carry out clinical validation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinical data of 522 vertigo patients were retrospectively analyzed, including 303 BPPV patients and 219 non-BPPV patients. LASSO regression and random forest algorithm were used to screen feature variables, and based on the screened feature variables, multifactor logistic regression analysis was performed to establish a prediction model for BPPV auxiliary diagnosis. Finally, the model was applied to BPPV patients diagnosed by SRM-IV diagnosis and treatment system for external validation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multifactorial logistic regression analysis showed that disease duration, neutrophils, lymphocytes, C-reactive protein (CRP), ferritin, and vitamin D deficiency were independent risk factors for the diagnosis of BPPV (OR&amp;gt;1, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.05), monocyte count was an independent protective factor for the diagnosis of BPPV (OR&amp;lt;1, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.05), and the area under curve (AUC) was 0.927.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The intelligent assisted diagnostic model of BPPV constructed based on the big data of SRM-IV vertigo diagnostic and treatment system has high diagnostic accuracy and clinical application value, and it is expected to assist the clinicians to improve the diagnostic efficiency.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2025.1636696","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T15:45:28Z","timestamp":1754581528000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Construction and clinical validation of benign paroxysmal positional vertigo intelligent auxiliary diagnosis model based on big data analysis"],"prefix":"10.3389","volume":"16","author":[{"given":"Jingyang","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"110008","DOI":"10.1016\/j.ijporl.2020.110008","article-title":"How rare is benign paroxysmal positional vertigo in children? A review of 20 cases and their epidemiology","volume":"132","author":"Choi","year":"2020","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1097\/AUD.0000000000001574","article-title":"Understanding factors that cause benign paroxysmal positional Vertigo, M\u00e9ni\u00e8re disease, and vestibular neuritis: a two-sample Mendelian randomization study","volume":"46","author":"Guo","year":"2025","journal-title":"Ear Hear"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"54","DOI":"10.9734\/JAMMR\/2022\/v34i2231578","article-title":"Epidemiological and clinical study of vertigo in a tertiary care hospital of Bangladesh","volume":"1","author":"Hannan","year":"2022","journal-title":"J Adv Med Med Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e34126","DOI":"10.2196\/34126","article-title":"A questionnaire-based ensemble learning model to predict the diagnosis of vertigo: model development and validation study","volume":"24","author":"Fangzhou","year":"2022","journal-title":"J Med Internet Res"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1002\/lary.31959","article-title":"Development and validation of a machine learning model for detection and classification of Vertigo","volume":"135","author":"Tang","year":"2025","journal-title":"Laryngoscope"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e70177","DOI":"10.1002\/lio2.70177","article-title":"Machine learning-based Mobile application for predicting Posterior Canal benign paroxysmal positional Vertigo","volume":"10","author":"Soylemez","year":"2025","journal-title":"Laryngoscope Investig Otolaryngol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1177\/09574271251351905","article-title":"Predictive modeling of maneuver numbers in BPPV therapy using machine learning","volume":"13","author":"Baydan-Aran","year":"2025","journal-title":"J Vestib Res"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"417","DOI":"10.3390\/s24113417","article-title":"Deep learning-based nystagmus detection for BPPV diagnosis","volume":"24","author":"Mun","year":"2024","journal-title":"Sensors (Basel)"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"432-435;441","DOI":"10.13201\/j.issn.2096-7993.2024.05.016","article-title":"Discussion and analysis the value of supine median3 nystagmus in the diagnosis and treatment of HC-BPPV","volume":"38","author":"Xing","year":"2024","journal-title":"Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1159\/000540036","article-title":"Residual dizziness characteristics of idiopathic sudden sensorineural hearing loss patients with benign paroxysmal positional vertigo","volume":"30","author":"Yang","year":"2024","journal-title":"Audiol Neurootol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"790430","DOI":"10.3389\/fneur.2021.790430","article-title":"Nystagmus parameters of supine roll test correlates with prognosis after repositioning maneuver in horizontal Semicircular Canal benign paroxysmal positional Vertigo","volume":"12","author":"Yu","year":"2021","journal-title":"Front Neurol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1177\/000348940911800206","article-title":"Benign paroxysmal positional vertigo: concomitant involvement of different semicircular canals","volume":"118","author":"Tomaz","year":"2009","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1204038","DOI":"10.3389\/fneur.2023.1204038","article-title":"Global research trends in benign paroxysmal positional vertigo: a bibliometric analysis","volume":"2","author":"Hu","year":"2023","journal-title":"Front Neurol"},{"key":"ref14","first-page":"1627","article-title":"Investigation of the relationship between chronic diseases and residual symptoms of benign paroxysmal positional vertigo","volume":"29","author":"Zhou","year":"2015","journal-title":"Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"120579","DOI":"10.1016\/j.jns.2023.120579","article-title":"Factors influencing clinical outcome in vestibular neuritis - a focussed review and reanalysis of prospective data","volume":"446","author":"Arshad","year":"2023","journal-title":"J Neurol Sci"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"103565","DOI":"10.1016\/j.amjoto.2022.103565","article-title":"Prevalence of anxiety and depression in Meniere's disease; a comparative analytical study","volume":"43","author":"Lahiji","year":"2022","journal-title":"Am J Otolaryngol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"881307","DOI":"10.3389\/fmed.2022.881307","article-title":"Clinical and cVEMP evaluation predict short-term residual dizziness after successful repositioning in benign paroxysmal positional Vertigo","volume":"9","author":"Jiang","year":"2022","journal-title":"Front Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"4913","DOI":"10.1177\/01455613241304913","article-title":"Influencing factors for residual symptoms following canalith repositioning maneuver in patients with benign paroxysmal positional vertigo","volume":"19","author":"Yan","year":"2025","journal-title":"Ear Nose Throat J"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"504","DOI":"10.13201\/j.issn.1001-1781.2019.06.007","article-title":"The correlations between serum vitamin D, parathyroid hormone, and bone mineral density with benign paroxysmal positional vertigo","volume":"33","author":"Zhang","year":"2019","journal-title":"Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1007\/s41666-024-00178-1","article-title":"Classification of chronic dizziness using large language models","volume":"9","author":"Xu","year":"2024","journal-title":"J Healthc Inform Res"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"120454","DOI":"10.1016\/j.jns.2022.120454","article-title":"Deep learning in acute vertigo diagnosis","volume":"443","author":"Rastall","year":"2022","journal-title":"J Neurol Sci"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"6170","DOI":"10.1007\/s00415-023-11922-9","article-title":"Neurological update: neuro-otology 2023","volume":"270","author":"Halm\u00e1gyi","year":"2023","journal-title":"J Neurol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3390\/computation12080167","article-title":"Methods for detecting the patient\u2019s pupils\u2019 coordinates and head rotation angle for the video head impulse test (vHIT), applicable for the diagnosis of vestibular neuritis and pre-stroke conditions","volume":"12","author":"Mamykin","year":"2024","journal-title":"Computation"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"3534","DOI":"10.1002\/lary.30708","article-title":"Development of a predictive model for persistent dizziness following vestibular schwannoma surgery","volume":"133","author":"Suresh","year":"2023","journal-title":"Laryngoscope"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1636696\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T15:13:34Z","timestamp":1756221214000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1636696\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,7]]},"references-count":24,"alternative-id":["10.3389\/fneur.2025.1636696"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2025.1636696","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,7]]},"article-number":"1636696"}}