{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T00:04:00Z","timestamp":1754093040388,"version":"3.41.2"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Spinal cord injury (SCI) causes motor, sensory and autonomic dysfunction below the level of injury and its incidence is increasing every year. Astragalus Membranaceus Extract (AME) has received attention in spinal cord injury in recent years, but its specific effects in spinal cord injury are unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Databases of PubMed, Embase, WOS, Cochrane Library, FMRS, Clinical trial, CNKI, VIP, and WangFang were searched from their establishment to December 1, 2024 using the following terms: \u201cAstragalus propinquus,\u201d \u201cHuang qi,\u201d \u201c<jats:italic>Astragalus mongholicus<\/jats:italic> Bunge,\u201d \u201cSpinal cord injuries,\u201d \u201cspinal cord diseases,\u201d \u201cspinal cord trauma.\u201d To ensure comprehensiveness, the search strategy included both traditional names (Astragalus) and scientific names (Astragalus membranaceus). Only studies published in Chinese or English were included. Cross-sectional studies, survey designs, quality improvement studies, and other study designs that did not meet the inclusion criteria were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After screening, a total of 16 studies with 996 animals were included in the review. Astragalus Membranaceus Extract (AME) administration was associated with more significant functional recovery (mean difference [MD]\u202f=\u202f3.68, 95% CI\u202f=\u202f2.74, 4.62). Subgroup analyses showed the best functional recovery of the spinal cord when the dose exceeded 20\u202funits and the duration of treatment was less than 14\u202fdays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study suggests that AME has therapeutic potential for spinal cord injured rats. Further studies are needed to determine if this can be developed into a new alternative therapy through experimental and clinical studies with larger samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic review registration<\/jats:title><jats:p>Identifier: CRD42024623721, website: <jats:uri>https:\/\/www.crd.york.ac.uk\/PROSPERO\/<\/jats:uri><\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2025.1637608","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T04:10:30Z","timestamp":1754021430000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Intervention of Astragalus Membranaceus Extract in rats of spinal cord injury: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"16","author":[{"given":"Hongli","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanlan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zichao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengjiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"7533","DOI":"10.3390\/ijms21207533","article-title":"Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms","volume":"21","author":"Anjum","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1017\/S0317167100014530","article-title":"Global incidence and prevalence of traumatic spinal cord injury","volume":"40","author":"Furlan","year":"2013","journal-title":"Can J Neurol Sci"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"683","DOI":"10.3171\/2018.10.SPINE18802","article-title":"Neurological recovery following traumatic spinal cord injury: a systematic review and meta-analysis","volume":"30","author":"Khorasanizadeh","year":"2019","journal-title":"J Neurosurg Spine"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1159\/000520112","article-title":"Epidemiological review of spinal cord injury due to road traffic accidents in Latin America","volume":"31","author":"Fern\u00e1ndez Londo\u00f1o","year":"2022","journal-title":"Med Princ Pract"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.ncl.2021.02.004","article-title":"Acute traumatic spinal cord injury","volume":"39","author":"Eli","year":"2021","journal-title":"Neurol Clin"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"113","DOI":"10.24095\/hpcdp.33.3.01","article-title":"The economic burden of traumatic spinal cord injury in Canada","volume":"33","author":"Krueger","year":"2013","journal-title":"Chronic Dis Inj Can"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1097\/BRS.0000000000004417","article-title":"Spinal cord injury: the global incidence, prevalence, and disability from the global burden of disease study 2019","volume":"47","author":"Ding","year":"2022","journal-title":"Spine"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.4103\/1673-5374.382257","article-title":"Epidemiological and clinical features, treatment status, and economic burden of traumatic spinal cord injury in China: a hospital-based retrospective study","volume":"19","author":"Zhou","year":"2024","journal-title":"Neural Regen Res"},{"key":"ref9","first-page":"56","article-title":"GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators. 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