{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:32:25Z","timestamp":1791952345926,"version":"4.3.4"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Ethnic disparities in Early-onset Alzheimer\u2019s Disease (EOAD) have not been fully characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively identified 81 EOAD patients February 2017\u2013February 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>53 (65.4%) identified as White and 28 (34.6%) identified as Black. Age at diagnosis (years) was (57.3\u202f\u00b1\u202f5.24) in Black patients compared to (56.3\u202f\u00b1\u202f4.96) in White patients. Time to diagnosis (years) was longer in Black patients (3.39\u202f\u00b1\u202f1.85) compared with White patients (2.64\u202f\u00b1\u202f1.75). Black patients had lower MOCA scores (12.17\u202f\u00b1\u202f6.9) compared with White patients (14.9\u202f\u00b1\u202f5.8). An amnestic profile was more common in Black patients (19 or 67.9%) than non-amnestic presentations (9 or 32.1%). Non-amnestic presentations were more common in White patients, with 9 (17%) patients with PCA, 8 (15%) with fAD and 8 (15%) with l-PPA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>In our cohort, Black patients with EOAD are on average older, more advanced and experienced longer delays in diagnosis than their White counterparts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2025.1643514","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T19:59:55Z","timestamp":1765396795000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Ethnic disparities in patients with early-onset Alzheimer\u2019s disease (EOAD)"],"prefix":"10.3389","volume":"16","author":[{"given":"Meredith","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suemin Jasmine","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Taruc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis","family":"Timpo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Mastrianni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin","family":"Seibert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1001\/jamaneurol.2020.4471","article-title":"Trends in relative incidence and prevalence of dementia across non-Hispanic black and white individuals in the United States, 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