{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:24:24Z","timestamp":1778498664935,"version":"3.51.4"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Obstructive sleep apnea (OSA) is highly prevalent in polio survivors, but longitudinal data on its progression remain limited. This study aimed to characterize OSA progression in community-dwelling polio survivors and compare it with an age-matched control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective 5-year longitudinal study recruited 148 polio survivors (48.76\u202f\u00b1\u202f5.97\u202fyears, 75% male). At baseline (2014), all participants underwent overnight oximetry. Among them, 42 completed in-lab polysomnography (PSG) testing. Over the 5-year follow-up, 112 polio survivors (76.79% male, mean age 48.48\u202f\u00b1\u202f6.05\u202fyears) were successfully tracked, with 33 undergoing follow-up PSG. Additionally, 59 age- and sex-matched OSA patients were enrolled as controls. Primary outcomes included changes in oxygen desaturation index \u22654% (ODI<jats:sub>4<\/jats:sub>) and apnea-hypopnea index (AHI). Correlates of OSA progression were analyzed using Pearson\u2019s correlations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over 5\u202fyears, ODI<jats:sub>4<\/jats:sub> increased significantly in polio survivors from 8.11\u202f\u00b1\u202f9.13 to 10.35\u202f\u00b1\u202f11.63 events\/h (<jats:italic>p<\/jats:italic>\u202f=\u202f0.01), with a shift toward moderate\u2013severe ODI<jats:sub>4<\/jats:sub> (13 to 22%, <jats:italic>p<\/jats:italic>\u202f=\u202f0.027). AHI also rose in both groups: polio survivors (26.57\u202f\u00b1\u202f21.25 to 33.86\u202f\u00b1\u202f22.43 events\/h, <jats:italic>p<\/jats:italic>\u202f=\u202f0.02) and controls (27.14\u202f\u00b1\u202f21.91 to 37.24\u202f\u00b1\u202f24.55 events\/h, <jats:italic>p<\/jats:italic>\u202f=\u202f0.004), with no significant group difference in AHI progression (<jats:italic>p<\/jats:italic>\u202f=\u202f0.89). However, polio survivors showed increased mixed apnea index (<jats:italic>p<\/jats:italic>\u202f=\u202f0.02) and prolonged REM sleep latency (<jats:italic>p<\/jats:italic>\u202f=\u202f0.009). ODI<jats:sub>4<\/jats:sub> changes correlated with scoliosis (<jats:italic>r<\/jats:italic>\u202f=\u202f0.27, <jats:italic>p<\/jats:italic>\u202f=\u202f0.005) and BMI fluctuations (<jats:italic>r<\/jats:italic> =\u202f0.25, <jats:italic>p<\/jats:italic>\u202f=\u202f0.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OSA-related parameters, particularly mixed apnea and REM alterations, progress in polio survivors. Changes in ODI<jats:sub>4<\/jats:sub> were positively correlated with BMI fluctuations and scoliosis.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2025.1643862","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T04:17:50Z","timestamp":1760069870000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Obstructive sleep apnea in community-dwelling polio survivors: a 5-year longitudinal follow-up study"],"prefix":"10.3389","volume":"16","author":[{"given":"Qidi","family":"Ding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunliang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinxian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaosong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhua","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changjun","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kingman P.","family":"Strohl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"ref1","first-page":"12","volume-title":"Communiqu\u00e9 on major data of the second National Sample Survey of people with disabilities (no. 2). Chinese Disabled","author":"Ji","year":"2007"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1212\/WNL.49.4.1189-a","article-title":"Sleep apnea syndrome among poliomyelitis survivors","volume":"49","author":"Ulfberg","year":"1997","journal-title":"Neurology"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3233\/NRE-1997-8207","article-title":"Pulmonary dysfunction and its management in post-polio patients","volume":"8","author":"Bach","year":"1997","journal-title":"NeuroRehabilitation"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.rehab.2019.10.007","article-title":"Sleep disorders in aging polio survivors: a systematic review","volume":"63","author":"Leotard","year":"2020","journal-title":"Ann Phys Rehabil Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1093\/sleep\/26.6.703","article-title":"Predictors of longitudinal change in sleep-disordered breathing in a 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