{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:16:21Z","timestamp":1783466181919,"version":"3.55.0"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>There is a well-established but poorly understood pathological and clinical overlap between cerebral amyloid angiopathy (CAA) and Alzheimer\u2019s disease (AD). Some studies have suggested a posterior predominance of CAA-related lesions, but it remains unclear how well this can be captured by specific measures of low- to high-level visual cortical processing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared the characteristics of 30 patients with AD and\/or CAA, grouped by impairment measures of low- to mid-level visual cortical processing, and explored associations with clinical characteristics, neurodegeneration biomarkers, CAA imaging features, and volumetric structural measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty participants were classified as impaired on tasks of low- to mid-level visual cortical function. Impairment in these tasks was associated with performance on more complex visuoconstruction tasks, which in turn showed a correlation with structural integrity volume and cortical thickness in the occipital lobe. We found no association between impairment in low- to mid-level visual cortical functions or visuoconstruction tasks and specific measures of CAA or AD pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Impairments in visuospatial functions, although reflecting structural damage in posterior brain regions, were not independently associated with markers of CAA or AD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2025.1647079","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T04:11:54Z","timestamp":1757304714000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Visuospatial processing in patients with Alzheimer\u2019s disease and cerebral amyloid angiopathy"],"prefix":"10.3389","volume":"16","author":[{"given":"Ana Sofia","family":"Costa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Albrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani","family":"Ridwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg B.","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Reetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Pinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41582-019-0281-2","article-title":"Cerebral amyloid angiopathy and Alzheimer 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