{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:42:19Z","timestamp":1760330539255,"version":"build-2065373602"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Acoustic neuroma (AN), or vestibular schwannoma, is a benign tumor of the eighth cranial nerve. Radiotherapy is a key treatment modality. This systematic review and meta-analysis evaluate post-radiotherapy hearing preservation in patients with AN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Following PRISMA guidelines, 36 studies published from 2011 to 2020 were identified through searches in PubMed, Cochrane, and Semantic Scholar. Data from 3,903 patients were analyzed using RevMan 5.3. Random-effects models were applied to account for heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pooled hearing preservation rate post-radiotherapy was 55.9%. Gamma Knife and single-session protocols were associated with higher preservation rates. Male sex was linked to a significantly higher risk of hearing loss (RR\u202f=\u202f0.83, 95% CI: 0.69\u20130.99). Tumor control was achieved in the majority of cases (RR\u202f=\u202f2.95, 95% CI: 1.94\u20134.29). Hearing preservation declined with longer follow-up durations. Secondary outcomes included tinnitus, imbalance, and facial nerve dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Radiotherapy offers favorable tumor control with variable hearing preservation, influenced by treatment modality, sex, and follow-up duration. These findings inform patient counseling and support the need for standardized outcome measures in future studies.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2025.1647374","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:16:56Z","timestamp":1760329016000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hearing preservation of post-radiotherapy for acoustic neuroma\u2014a systematic review and 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