{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T10:06:47Z","timestamp":1762423607335,"version":"build-2065373602"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The familial association of psoriasis with multiple sclerosis (MS) has been observed in several international studies. Whether this link is applicable in an Australian setting has yet to be established. The aim of this study was to evaluate the prevalence of psoriasis in family members of an MS cohort in the Australian population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A survey study of adult MS patients was conducted between 2018 and 2021 at the MS clinic, Royal North Shore Hospital, Sydney, Australia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 204 MS participants, with mean age of 48.8\u202fyears, were included in the study. Of these participants, 67 were male (32.8%) and 137 were female (67.2%). An increased rate of psoriasis was found among family members of MS patients: 35 (17.2%) MS patients had family history of psoriasis, and 11 patients reported a history of psoriasis themselves. Of the 35 MS patients with family history of psoriasis, female participants were found to be at a higher risk of psoriasis (34.6%,\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f9\/26) as compared to their male counterparts (22.2%,\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f2\/9).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This study demonstrates a significantly increased risk of psoriasis among family members of MS patients, suggesting overlap in genetic risk between the two immune-mediated diseases. Further prospective research is warranted to determine the characteristics of association in MS individuals with psoriasis or\/and family history of psoriasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2025.1663031","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T10:03:30Z","timestamp":1762423410000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Familial prevalence of psoriasis in patients with multiple sclerosis \u2013 results from an Australian survey"],"prefix":"10.3389","volume":"16","author":[{"given":"Varitsara","family":"Mangkorntongsakul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariadna","family":"Fontes-Villalba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Ting Justin","family":"Kwong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Charlton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen Marie","family":"McGuire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turlough","family":"Montague","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Phan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkatesha","family":"Venkatesha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey","family":"Herkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saxon","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Parratt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/nrdp.2016.82","article-title":"Psoriasis","volume":"2","author":"Greb","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/s41572-018-0041-4","article-title":"Multiple sclerosis","volume":"4","author":"Filippi","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1177\/1352458519887328","article-title":"Race and ethnicity on MS presentation and disease course","volume":"26","author":"Amezcua","year":"2020","journal-title":"Mult Scler J"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"81","DOI":"10.2147\/PTT.S186637","article-title":"A narrative review of psoriasis and multiple sclerosis: links and risks","volume":"9","author":"Silfvast-Kaiser","year":"2019","journal-title":"Psoriasis Targets Ther"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"101421","DOI":"10.1016\/j.msard.2019.101421","article-title":"Psoriasis in family members of patients with multiple sclerosis","volume":"36","author":"Charlton","year":"2019","journal-title":"Mult Scler Relat Disord"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s40257-018-0399-9","article-title":"Association of multiple sclerosis with psoriasis: a systematic review and meta-analysis of observational studies","volume":"20","author":"Liu","year":"2019","journal-title":"Am J Clin Dermatol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/JID.2015.350","article-title":"Risk of multiple sclerosis in patients with psoriasis: a Danish nationwide cohort study","volume":"136","author":"Egeberg","year":"2016","journal-title":"J Invest Dermatol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.msard.2017.02.012","article-title":"Increased incidence and prevalence of psoriasis in multiple sclerosis","volume":"13","author":"Marrie","year":"2017","journal-title":"Mult Scler Relat Disord"},{"key":"ref9","first-page":"575","article-title":"Multiple sclerosis and psoriasis","volume":"42","author":"Cendrowski","year":"1989","journal-title":"Wiadomosci Lekarskie (Warsaw, Poland: 1960)"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1038\/ng.3395","article-title":"Class II HLA interactions modulate genetic risk for multiple sclerosis","volume":"47","author":"Moutsianas","year":"2015","journal-title":"Nat Genet"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2658","DOI":"10.3389\/fimmu.2021.705485","article-title":"The TNFR1 antagonist Atrosimab is therapeutic in mouse models of acute and chronic inflammation","volume":"12","author":"Richter","year":"2021","journal-title":"Front Immunol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3389\/fcell.2019.00091","article-title":"TNFR1 and TNFR2 in the control of the life and death balance of macrophages","volume":"7","author":"Wajant","year":"2019","journal-title":"Front Cell Dev Biol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"18847","DOI":"10.7759\/cureus.18847","article-title":"Tumor necrosis factor alpha blockade and multiple sclerosis: exploring new avenues","volume":"13","author":"Zahid","year":"2021","journal-title":"Cureus"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"10622","DOI":"10.1038\/s41598-023-36846-2","article-title":"The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration","volume":"13","author":"Ort\u00ed-Casa\u00f1","year":"2023","journal-title":"Sci Rep"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms7916","article-title":"Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility","volume":"6","author":"Yin","year":"2015","journal-title":"Nat Commun"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"743180","DOI":"10.3389\/fmed.2021.743180","article-title":"The global, regional, and national burden of psoriasis: results and insights from the global burden of disease 2019 study","volume":"8","author":"Damiani","year":"2021","journal-title":"Front Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1177\/1352458520970841","article-title":"Rising prevalence of multiple sclerosis worldwide: insights from the atlas of MS","volume":"26","author":"Walton","year":"2020","journal-title":"Mult Scler J"},{"key":"ref18","first-page":"11","article-title":"High frequency of psoriasis in relatives in a Turkish multiple sclerosis cohort","volume":"9","author":"Dogan","year":"2011","journal-title":"Skinmed"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/S1474-4422(06)70552-X","article-title":"Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: a descriptive study","volume":"5","author":"Barcellos","year":"2006","journal-title":"Lancet Neurol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1093\/brain\/123.6.1102","article-title":"Autoimmune disease in first-degree relatives of patients with multiple sclerosis: a UK survey","volume":"123","author":"Broadley","year":"2000","journal-title":"Brain"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1177\/1352458510375708","article-title":"Familial prevalence of autoimmune disorders in multiple sclerosis in northern Greece","volume":"16","author":"Deretzi","year":"2010","journal-title":"Mult Scler"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1034\/j.1600-0404.2003.00158.x","article-title":"High frequency of psoriasis in relatives is associated with early onset in an Italian multiple sclerosis cohort","volume":"108","author":"Annunziata","year":"2003","journal-title":"Acta Neurol Scand"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1007\/s00415-012-6790-1","article-title":"Autoimmune disease in people with multiple sclerosis and their relatives: a systematic review and meta-analysis","volume":"260","author":"Dobson","year":"2013","journal-title":"J Neurol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria","volume":"17","author":"Thompson","year":"2018","journal-title":"Lancet Neurol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2377-13-146","article-title":"Prevalence of cutaneous adverse events associated with long-term disease-modifying therapy and their impact on health-related quality of life in patients with multiple sclerosis: a cross-sectional study","volume":"13","author":"Balak","year":"2013","journal-title":"BMC Neurol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/j.1600-0404.1990.tb03308.x","article-title":"A case-control epidemiological study of MS in the Paris area with particular reference to past disease history and profession","volume":"82","author":"Souberbielle","year":"1990","journal-title":"Acta Neurol Scand"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1111\/j.1600-0404.1996.tb00004.x","article-title":"Multiple sclerosis and chronic inflammatory diseases a case-control study","volume":"93","author":"Midgard","year":"1996","journal-title":"Acta Neurol Scand"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1111\/ijd.14864","article-title":"Global burden of psoriasis\u2013comparison of regional and global epidemiology, 1990 to 2017","volume":"59","author":"AlQassimi","year":"2020","journal-title":"Int J Dermatol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"568","DOI":"10.3399\/bjgp12X658133","article-title":"Beyond skin: the need for a new approach to the management of psoriasis in primary care","volume":"62","author":"Cordingley","year":"2012","journal-title":"Br J Gen Pract"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1111\/cea.13741","article-title":"Ethnicity-based differences in the incident risk of allergic diseases and autoimmune disorders: a UK-based retrospective cohort study of 4.4 million participants","volume":"51","author":"Subramanian","year":"2020","journal-title":"Clin Exp Allergy"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1663031\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T10:03:31Z","timestamp":1762423411000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1663031\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,6]]},"references-count":30,"alternative-id":["10.3389\/fneur.2025.1663031"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2025.1663031","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,6]]},"article-number":"1663031"}}