{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:08:57Z","timestamp":1793837337371,"version":"4.6.1"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Clinical pharmacist (CP) integration within interprofessional healthcare team models may effectively provide secondary stroke prevention care and address healthcare disparities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This scoping review includes randomized controlled trials (RCTs) that evaluated the effect of interventions inclusive of team-based care by CPs on patient-oriented and health outcomes after stroke or transient ischemic attack (TIA). Search databases included MEDLINE\/PubMed, EMBASE, and CINAHL, and ClinicalTrials.gov and the International Standard Randomised Controlled Trial Number (ISRCTN) trial registries. We describe the level of interaction between interprofessional team members, use of telehealth services, population diversity, and intervention effects on study outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 132 RCTs, 14 met inclusion criteria and incorporated CPs in the intervention. These studies were conducted globally and included outcome measures such as medication adherence, morbidity and mortality, and vascular risk factor goal attainment. Twelve trials included multidisciplinary models, while two included interdisciplinary models, and none incorporated transdisciplinary models. Telehealth was leveraged in 8 of 14 trials. One study reported on healthcare disparities associated with poor risk factor control. Positive intervention effects were notable for goal attainment (4 of 10 trials).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Published RCTs examining CP impact within secondary stroke prevention teams with limited data suggests that interventions inclusive of CPs delivering medication education, reconciliation, and titration may improve vascular risk factor control, medication adherence, and patient-oriented outcomes. We highlight the need for future secondary stroke prevention clinical trials to provide more insight into CP integration, promote diversity in study populations and clinician roles, and incorporate telehealth to enhance healthcare access.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2025.1666409","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T04:21:14Z","timestamp":1758082874000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Integrating clinical pharmacists in care management for secondary stroke prevention clinical trials: a scoping review"],"prefix":"10.3389","volume":"16","author":[{"given":"James","family":"Thurston","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanlin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian M.","family":"Kronish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imama A.","family":"Naqvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e347","DOI":"10.1161\/CIR.0000000000001209","article-title":"2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association","volume":"149","author":"Martin","year":"2024","journal-title":"Circulation"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/S1474-4422(16)30073-4","article-title":"Global burden of stroke and risk factors in 188 countries, during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"15","author":"Feigin","year":"2016","journal-title":"Lancet Neurol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e364","DOI":"10.1161\/STR.0000000000000375","article-title":"2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association\/American Stroke Association","volume":"52","author":"Kleindorfer","year":"2021","journal-title":"Stroke"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1161\/STROKEAHA.108.539619","article-title":"Use of stroke secondary prevention services: are there disparities in care?","volume":"40","author":"Ross","year":"2009","journal-title":"Stroke"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.jstrokecerebrovasdis.2008.02.003","article-title":"The association of race and sex with the underuse of stroke prevention measures","volume":"17","author":"Tuhrim","year":"2008","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1161\/STR.0b013e3182213e24","article-title":"Racial-ethnic disparities in stroke care: the American experience: a statement for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"42","author":"Cruz-Flores","year":"2011","journal-title":"Stroke"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e031307","DOI":"10.1161\/JAHA.123.031307","article-title":"Achieving Blood Pressure Goals and Addressing Inequities in Blood Pressure Management After Stroke","volume":"13","author":"Bushnell","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"3538","DOI":"10.1161\/STROKEAHA.122.041020","article-title":"Telehealth After Stroke Care Pilot Randomized Trial of Home Blood Pressure Telemonitoring in an Underserved Setting","volume":"53","author":"Naqvi","year":"2022","journal-title":"Stroke"},{"key":"ref9","year":"2024"},{"key":"ref10","year":"2024"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1212\/WNL.0000000000012111","article-title":"A Shortage of Neurologists \u2013 We Must Act Now: A Report From the AAN 2019 Transforming Leaders Program","volume":"96","author":"Majersik","year":"2021","journal-title":"Neurology"},{"key":"ref12","first-page":"351","article-title":"Multidisciplinarity, interdisciplinarity and transdisciplinarity in health research, services, education and policy: 1. 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