{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:05:23Z","timestamp":1787504723289,"version":"build-2736575974"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Projects of Medical and Health Science and Technology in Shandong Province","award":["202303070650"],"award-info":[{"award-number":["202303070650"]}]},{"name":"Yantai Science and Technology Plan Project","award":["2021YD033"],"award-info":[{"award-number":["2021YD033"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Regarding the prognosis of patients with acute ischemic stroke (AIS) complicated by atrial fibrillation (AF) after thrombolysis, previous studies have reported conflicting results. This research investigates the connection between AF and in-hospital mortality following intravenous thrombolysis (IVT) in individuals with AIS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patient data were obtained from the Chinese Stroke Center Alliance (CSCA). This study constitutes a multicenter, retrospective cohort analysis, focusing on patients who received IVT using t-PA following an AIS. The primary outcome is adverse functional outcomes, characterized by in-hospital mortality. Safety outcomes mainly include cerebral hemorrhage. Univariate and multivariate logistic regression analyses were used to evaluate the relationship between AF and IVT outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 48,294 patients participated in the study, including 5,465 with a history of AF. Baseline characteristics indicated that patients in the AF group were of advanced age at the time of onset (74\u202fyears vs. 65\u202fyears,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). The NIHSS score at admission was higher (11 vs. 5,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), and a modified Rankin Scale (mRS) score \u22653 before admission was more common (28.7% vs. 24.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). Regarding safety results, patients suffering from AF had higher in-hospital mortality (3.1% vs. 0.8%; adjusted OR 1.77, 95% CI 1.41\u20132.23).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The study highlights that having a past of AF is linked to a higher chance of cerebral hemorrhage and in-hospital mortality in Chinese AIS patients following IVT. AF history is a strong predictor of in-hospital mortality (AUC\u202f=\u202f0.85).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2025.1667855","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T05:16:06Z","timestamp":1768367766000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Atrial fibrillation is associated with increased in-hospital mortality and complications after IV t-PA in acute ischemic stroke: evidence from the China Stroke Center Alliance (CSCA)"],"prefix":"10.3389","volume":"16","author":[{"given":"Liwen","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Neurology, Yantai Yuhuangding Hospital Affiliated to Qingdao University","place":["Yantai, China"]},{"name":"The Second Clinical Medical College, Binzhou Medical University","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruhui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yantai Yuhuangding Hospital Affiliated to Qingdao University","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yantai Yuhuangding Hospital Affiliated to Qingdao University","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yantai Yuhuangding Hospital Affiliated to Qingdao University","place":["Yantai, China"]},{"name":"The Second Clinical Medical College, Binzhou Medical University","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanye","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yantai Yuhuangding Hospital Affiliated to Qingdao University","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yantai Yuhuangding Hospital Affiliated to Qingdao University","place":["Yantai, China"]},{"name":"The Second Clinical Medical College, Binzhou Medical University","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuqing","family":"Luan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yantai Yuhuangding Hospital Affiliated to Qingdao University","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yantai Yuhuangding Hospital Affiliated to Qingdao University","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixuan","family":"Yang","sequence":"additional","affiliation":[{"name":"China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1136\/svn-2021-001374","article-title":"China stroke statistics: an update on the 2019 report from the National Center for healthcare quality Management in Neurological Diseases, China National Clinical Research Center for neurological diseases, the Chinese Stroke Association, National Center for chronic and non-communicable disease control and prevention, Chinese Center for Disease Control and Prevention and institute for global neuroscience and stroke 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