{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T05:52:38Z","timestamp":1764049958091,"version":"3.45.0"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Temporal lobe epilepsy (TLE) is a common form of drug-resistant epilepsy often treated with surgical interventions, including laser interstitial thermal therapy (LITT). However, patient-specific factors influencing LITT outcomes remain unclear. This retrospective study aimed to identify pre-operative resting-state functional MRI (rs-fMRI) patterns associated with seizure freedom following LITT in mesial TLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed rs-fMRI data from 28 patients with mesial TLE who underwent LITT, classifying them into seizure-free (SF) and not seizure-free (NSF) groups based on 12-month post-operative outcomes. Independent component analysis (ICA) was used to identify subject-specific brain networks, and generalized linear models (GLM) were employed to assess associations between pre-operative spatial patterns of ICA-derived functional connectivity (FC) and surgical outcomes, controlling for clinical variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Significant differences in brain ICA-derived FC patterns were observed between SF and NSF groups, with SF exhibiting more locally distributed ICA-derived FC patterns around the mesial temporal lobe, including the posterior orbitofrontal cortex (OFC) and anterior parahippocampal gyrus (PHG). In contrast, NSF demonstrated more diffusely distributed ICA-derived FC patterns encompassing the insula and thalami.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>These findings highlight the potential of pre-operative rs-fMRI as a prognostic tool for identifying TLE patients more likely to benefit from LITT. Further validation in larger cohorts is warranted to confirm these results and optimize patient selection for surgical interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2025.1675066","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T05:11:25Z","timestamp":1764047485000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Independent component analysis of resting-state fMRI identifies regions associated with seizure freedom after laser interstitial thermal therapy for temporal lobe epilepsy"],"prefix":"10.3389","volume":"16","author":[{"given":"Mahdi","family":"Alizadeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingya","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caio M.","family":"Matias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin J.","family":"Hines","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher T.","family":"Skidmore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Sperling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph I.","family":"Tracy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwini","family":"Sharan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengyuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"630853","DOI":"10.1155\/2012\/630853","article-title":"A review of the epidemiology of temporal lobe epilepsy","volume":"2012","author":"T\u00e9llez-Zenteno","year":"2012","journal-title":"Epilepsy Res Treat"},{"key":"B2","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s10143-023-02164-4","article-title":"Outcomes after laser interstitial thermal ablation for temporal lobe epilepsy: a systematic review and meta-analysis","volume":"46","author":"Alomar","year":"2023","journal-title":"Neurosurg Rev"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1111\/epi.15565","article-title":"Effects of surgical targeting in laser interstitial thermal therapy for mesial temporal lobe epilepsy: a multicenter study of 234 patients","volume":"60","author":"Wu","year":"2019","journal-title":"Epilepsia"},{"key":"B4","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.eplepsyres.2017.10.015","article-title":"A neurosurgeon\u2018s view: laser interstitial thermal therapy of mesial temporal lobe structures","volume":"142","author":"Bezchlibnyk","year":"2018","journal-title":"Epilepsy Res"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e1121","DOI":"10.1016\/j.wneu.2019.03.057","article-title":"Magnetic resonance-guided laser interstitial thermal therapy for mesial temporal epilepsy: a case series analysis of outcomes and complications at 2-year follow-up","volume":"126","author":"Cajigas","year":"2019","journal-title":"World Neurosurg."},{"key":"B6","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.yebeh.2017.10.041","article-title":"The impact of stereotactic laser ablation at a typical epilepsy center","volume":"78","author":"Petito","year":"2018","journal-title":"Epilepsy Behav"},{"key":"B7","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1136\/jnnp-2022-330979","article-title":"Long-term outcomes of mesial temporal laser interstitial thermal therapy for drug-resistant epilepsy and subsequent surgery for seizure recurrence: a multi-centre cohort study","volume":"94","author":"Youngerman","year":"2023","journal-title":"J Neurol Neurosurg Psychiatr"},{"key":"B8","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1136\/jnnp-2017-316833","article-title":"Stereotactic EEG-guided laser interstitial thermal therapy for mesial temporal lobe epilepsy","volume":"89","author":"Tao","year":"2018","journal-title":"J Neurol Neurosurg Psychiatr"},{"key":"B9","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1111\/epi.17183","article-title":"Long-term seizure and psychiatric outcomes following laser ablation of mesial temporal structures","volume":"63","author":"Kanner","year":"2022","journal-title":"Epilepsia"},{"key":"B10","doi-asserted-by":"publisher","first-page":"106644","DOI":"10.1016\/j.clineuro.2021.106644","article-title":"meta-analysis on potential modifiers of LITT efficacy for mesial temporal lobe epilepsy: seizure-freedom seems to fade with time","volume":"205","author":"Brotis","year":"2021","journal-title":"Clin Neurol Neurosurg."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.3171\/2020.11.JNS203261","article-title":"Extent of parahippocampal ablation is associated with seizure freedom after laser amygdalohippocampotomy","volume":"135","author":"Satzer","year":"2021","journal-title":"J Neurosurg"},{"key":"B12","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1111\/epi.13715","article-title":"Laser thermal ablation for mesiotemporal epilepsy: analysis of ablation volumes and trajectories","volume":"58","author":"Jermakowicz","year":"2017","journal-title":"Epilepsia"},{"key":"B13","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1046\/j.1528-1157.2002.26901.x","article-title":"Neural networks in human epilepsy: evidence of and implications for treatment","volume":"43","author":"Spencer","year":"2002","journal-title":"Epilepsia"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1111\/epi.13510","article-title":"Regional and global connectivity disturbances in focal epilepsy, related neurocognitive sequelae, and potential mechanistic underpinnings","volume":"57","author":"Englot","year":"2016","journal-title":"Epilepsia"},{"key":"B15","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.wneu.2016.02.023","article-title":"Historical risk factors associated with seizure outcome after surgery for drug-resistant mesial temporal lobe epilepsy","volume":"89","author":"Asadi-Pooya","year":"2016","journal-title":"World Neurosurg"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1111\/j.1528-1167.2011.03191.x","article-title":"Functional MRI connectivity as a predictor of the surgical outcome of epilepsy","volume":"52","author":"Negishi","year":"2011","journal-title":"Epilepsia"},{"key":"B17","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.seizure.2020.01.018","article-title":"Surgical disconnection of epilepsy network correlates with improved outcomes","volume":"76","author":"Neal","year":"2020","journal-title":"Seizure"},{"key":"B18","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S1053-8119(03)00097-1","article-title":"Independent component analysis of nondeterministic fMRI signal sources","volume":"19","author":"Kiviniemi","year":"2003","journal-title":"Neuroimage"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e0257678","DOI":"10.1371\/journal.pone.0257678","article-title":"Occult focal cortical dysplasia may predict poor outcome of surgery for drug-resistant mesial temporal lobe epilepsy","volume":"16","author":"Nowak","year":"2021","journal-title":"PLoS ONE"},{"key":"B20","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","article-title":"FSL","volume":"62","author":"Jenkinson","year":"2012","journal-title":"Neuroimage"},{"key":"B21","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1089\/brain.2016.0479","article-title":"Correlating resting-state functional magnetic resonance imaging connectivity by independent component analysis-based epileptogenic zones with intracranial electroencephalogram localized seizure onset zones and surgical outcomes in prospective pediatric intractable Epilepsy Study","volume":"7","author":"Boerwinkle","year":"2017","journal-title":"Brain Connect"},{"key":"B22","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3389\/fnhum.2016.00075","article-title":"Studying sub-dendrograms of resting-state functional networks with voxel-wise hierarchical clustering","volume":"10","author":"Wang","year":"2016","journal-title":"Front Hum Neurosci"},{"key":"B23","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1006\/nimg.2001.0978","article-title":"Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain","volume":"15","author":"Tzourio-Mazoyer","year":"2002","journal-title":"Neuroimage"},{"key":"B24","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.wneu.2020.07.194","article-title":"Surgical outcomes of laser interstitial thermal therapy for temporal lobe epilepsy: systematic review and meta-analysis","volume":"143","author":"Kerezoudis","year":"2020","journal-title":"World Neurosurg"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1111\/epi.14443","article-title":"Laser ablation for mesial temporal lobe epilepsy: surgical and cognitive outcomes with and without mesial temporal sclerosis","volume":"59","author":"Donos","year":"2018","journal-title":"Epilepsia"},{"key":"B26","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1111\/epi.14004","article-title":"Laser ablation is effective for temporal lobe epilepsy with and without mesial temporal sclerosis if hippocampal seizure onsets are localized by stereoelectroencephalography","volume":"59","author":"Youngerman","year":"2018","journal-title":"Epilepsia"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.3892\/etm.2015.2753","article-title":"Predictors of prognosis in patients with temporal lobe epilepsy after anterior temporal lobectomy","volume":"10","author":"Sun","year":"2015","journal-title":"Exp Ther Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1111\/ane.13008","article-title":"\u201cTime is Brain\u201d-How early should surgery be done in drug-resistant TLE?","volume":"138","author":"Radhakrishnan","year":"2018","journal-title":"Acta Neurol Scand"},{"key":"B29","doi-asserted-by":"publisher","first-page":"23153","DOI":"10.1038\/srep23153","article-title":"Functional connectome before and following temporal lobectomy in mesial temporal lobe epilepsy","volume":"6","author":"Liao","year":"2016","journal-title":"Sci Rep"},{"key":"B30","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1186\/s12883-021-02469-1","article-title":"Mapping connectivity fingerprints for presurgical evaluation of temporal lobe epilepsy","volume":"21","author":"Sala-Padro","year":"2021","journal-title":"BMC Neurol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/epi.13284","article-title":"Laser interstitial thermal therapy for medically intractable mesial temporal lobe epilepsy","volume":"57","author":"Kang","year":"2016","journal-title":"Epilepsia"},{"key":"B32","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1523\/ENEURO.0141-22.2022","article-title":"Interictal gamma event connectivity differentiates the seizure network and outcome in patients after temporal lobe epilepsy surgery","volume":"9","author":"Shamas","year":"2022","journal-title":"eNeuro"},{"key":"B33","doi-asserted-by":"publisher","first-page":"840481","DOI":"10.3389\/fnins.2022.840481","article-title":"Altered temporal variations of functional connectivity associated with surgical outcomes in drug-resistant temporal lobe epilepsy","volume":"16","author":"Guo","year":"2022","journal-title":"Front Neurosci"},{"key":"B34","doi-asserted-by":"publisher","first-page":"107841","DOI":"10.1016\/j.yebeh.2021.107841","article-title":"Regional and global resting-state functional MR connectivity in temporal lobe epilepsy: results from the Epilepsy Connectome Project","volume":"117","author":"Struck","year":"2021","journal-title":"Epilepsy Behav"},{"key":"B35","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.eplepsyres.2009.10.018","article-title":"Functional epileptic network in left mesial temporal lobe epilepsy detected using resting fMRI","volume":"88","author":"Morgan","year":"2010","journal-title":"Epilepsy Res"},{"key":"B36","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1148\/radiol.2020191008","article-title":"Contralateral preoperative resting-state functional MRI network integration is associated with surgical outcome in temporal lobe epilepsy","volume":"294","author":"DeSalvo","year":"2020","journal-title":"Radiology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1212\/WNL.0000000000004035","article-title":"Presurgical thalamic \u201chubness\u201d predicts surgical outcome in temporal lobe epilepsy","volume":"88","author":"He","year":"2017","journal-title":"Neurology"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1201682","DOI":"10.3389\/fnimg.2023.1201682","article-title":"Profiles of resting state functional connectivity in temporal lobe epilepsy associated with post-laser interstitial thermal therapy seizure outcomes and semiologies","volume":"2","author":"Syed","year":"2023","journal-title":"Front Neuroimaging"},{"key":"B39","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.yebeh.2018.10.025","article-title":"Association between seizure freedom and default mode network reorganization in patients with unilateral temporal lobe epilepsy","volume":"90","author":"Ofer","year":"2019","journal-title":"Epilepsy Behav"},{"key":"B40","doi-asserted-by":"publisher","first-page":"18389","DOI":"10.1038\/s41598-022-23297-4","article-title":"Amplitude synchronization of spontaneous activity of medial and lateral temporal gyri reveals altered thalamic connectivity in patients with temporal lobe epilepsy","volume":"12","author":"Sathe","year":"2022","journal-title":"Sci Rep"},{"key":"B41","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.seizure.2021.04.007","article-title":"Association of hypometabolic extension of 18F-FDG PET with diffusion tensor imaging indices in mesial temporal lobe epilepsy with hippocampal sclerosis","volume":"88","author":"Tatekawa","year":"2021","journal-title":"Seizure."},{"key":"B42","doi-asserted-by":"publisher","first-page":"103210","DOI":"10.1016\/j.nicl.2022.103210","article-title":"Metabolic connectivity is associated with seizure outcome in surgically treated temporal lobe epilepsies: a 18F-FDG PET seed correlation analysis","volume":"36","author":"Doyen","year":"2022","journal-title":"Neuroimage Clin."},{"key":"B43","doi-asserted-by":"publisher","first-page":"107714","DOI":"10.1016\/j.yebeh.2020.107714","article-title":"Quantitative [18]FDG PET asymmetry features predict long-term seizure recurrence in refractory epilepsy","volume":"116","author":"Kini","year":"2021","journal-title":"Epilepsy Behav."},{"key":"B44","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1002\/ana.410320613","article-title":"Temporal lobectomy for uncontrolled seizures: the role of positron emission tomography","volume":"32","author":"Theodore","year":"1992","journal-title":"Ann Neurol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"2276","DOI":"10.1093\/brain\/awh257","article-title":"MRI-negative PET-positive temporal lobe epilepsy: a distinct surgically remediable syndrome","volume":"127","author":"Carne","year":"2004","journal-title":"Brain"},{"key":"B46","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1093\/brain\/awh014","article-title":"Metabolic changes and electro-clinical patterns in mesio-temporal lobe epilepsy: a correlative study","volume":"127","author":"Chassoux","year":"2004","journal-title":"Brain"},{"key":"B47","doi-asserted-by":"publisher","first-page":"102714","DOI":"10.1016\/j.nicl.2021.102714","article-title":"Structural and functional reorganization of contralateral hippocampus after temporal lobe epilepsy surgery","volume":"31","author":"Li","year":"2021","journal-title":"Neuroimage Clin."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e1737","DOI":"10.1097\/MD.0000000000001737","article-title":"Connectome reorganization associated with surgical outcome in temporal lobe epilepsy","volume":"94","author":"Ji","year":"2015","journal-title":"Medicine."},{"key":"B49","doi-asserted-by":"publisher","first-page":"e67","DOI":"10.1212\/WNL.0000000000005733","article-title":"Relating structural and functional brainstem connectivity to disease measures in epilepsy","volume":"91","author":"Englot","year":"2018","journal-title":"Neurology"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1213224","DOI":"10.3389\/fneur.2023.1213224","article-title":"Structural and functional changes of the cerebellum in temporal lobe epilepsy","volume":"14","author":"Wang","year":"2023","journal-title":"Front Neurol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1111\/j.1528-1157.1996.tb00652.x","article-title":"Localized cerebellar hypometabolism in patients with complex partial seizures","volume":"37","author":"Savic","year":"1996","journal-title":"Epilepsia"},{"key":"B52","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.neuroimage.2006.04.185","article-title":"Correlations of interictal FDG-PET metabolism and ictal SPECT perfusion changes in human temporal lobe epilepsy with hippocampal sclerosis","volume":"32","author":"Nelissen","year":"2006","journal-title":"Neuroimage"},{"key":"B53","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.seizure.2017.12.004","article-title":"Morphological changes of cerebellar substructures in temporal lobe epilepsy: a complex phenomenon, not mere atrophy","volume":"54","author":"Marci\u00e1n","year":"2018","journal-title":"Seizure"},{"key":"B54","doi-asserted-by":"publisher","first-page":"e0158728","DOI":"10.1371\/journal.pone.0158728","article-title":"Graph theoretical analysis of structural neuroimaging in temporal lobe epilepsy with and without psychosis","volume":"11","author":"Sone","year":"2016","journal-title":"PLoS ONE"},{"key":"B55","doi-asserted-by":"publisher","first-page":"e0295142","DOI":"10.1371\/journal.pone.0295142","article-title":"Functional correlates of cognitive performance and working memory in temporal lobe epilepsy: insights from task-based and resting-state fMRI","volume":"19","author":"Fajardo-Valdez","year":"2024","journal-title":"PLoS ONE"},{"key":"B56","doi-asserted-by":"publisher","first-page":"102231","DOI":"10.1016\/j.nicl.2020.102231","article-title":"Microstructural imaging in temporal lobe epilepsy: diffusion imaging changes relate to reduced neurite density","volume":"26","author":"Winston","year":"2020","journal-title":"Neuroimage Clin."},{"key":"B57","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/hbm.460020402","article-title":"Statistical parametric maps in functional imaging: a general linear approach","volume":"2","author":"Friston","year":"1994","journal-title":"Hum Brain Mapp."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/nimg.2001.0933","article-title":"A general statistical analysis for fMRI data","volume":"15","author":"Worsley","year":"2002","journal-title":"Neuroimage"},{"key":"B59","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/nn1050","article-title":"Voxel-based lesion-symptom mapping","volume":"6","author":"Bates","year":"2003","journal-title":"Nat Neurosci"},{"key":"B60","doi-asserted-by":"publisher","first-page":"118090","DOI":"10.1016\/j.neuroimage.2021.118090","article-title":"Voxel-wise and spatial modelling of binary lesion masks: comparison of methods with a realistic simulation framework","volume":"236","author":"Kindalova","year":"2021","journal-title":"Neuroimage."},{"key":"B61","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/nrn1521","article-title":"Using human brain lesions to infer function: a relic from a past era in the fMRI age?","volume":"5","author":"Rorden","year":"2004","journal-title":"Nat Rev Neurosci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1007\/s11682-023-00835-w","article-title":"Similarities and differences of dynamic and static spontaneous brain activity between left and right temporal lobe epilepsy","volume":"18","author":"Song","year":"2024","journal-title":"Brain Imaging Behav."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1675066\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T05:11:25Z","timestamp":1764047485000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1675066\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":62,"alternative-id":["10.3389\/fneur.2025.1675066"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2025.1675066","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"article-number":"1675066"}}