{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:12:19Z","timestamp":1793319139911,"version":"4.5.0"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To identify clinical factors associated with pain perception, psychological status, and sleep quality in patients with trigeminal neuralgia (TN) and to evaluate the clinical efficacy of individualized comprehensive nursing interventions in alleviating pain, anxiety, depression, and sleep disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study combined retrospective with prospective design. The retrospective analysis included 162 patients with TN admitted to our hospital from January 2020 and March 2022. Patients were grouped based on their scores on the Visual Analogue Scale (VAS), Hospital Anxiety and Depression Scale (HADS), and Pittsburgh Sleep Quality Index (PSQI). In the prospective arm, 64 eligible patients were assigned into intervention (individualized nursing care) and control (standard routine care) groups using a random number table. Changes in VAS, HADS, and PSQI scores before and after the intervention were compared, along with assessments of nursing adherence and patient satisfaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Retrospective analysis revealed that sex, frequency of pain episodes, comorbid hypertension, and history of surgical treatment were associated with pain scores. Pain distribution and previous treatment methods were correlated with anxiety\/depression. Frequency of pain and pain distribution were major factors affecting sleep quality. In the prospective study, the intervention group showed significantly lower VAS, HADS-Anxiety, HADS-Depression, and PSQI scores. The intervention group also demonstrated better adherence to nursing and higher nursing satisfaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Risk-factor based targeted nursing interventions can alleviate pain, negative emotions, and sleep disturbances, while enhancing adherence and patient satisfaction, demonstrating strong clinical value in TN management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2025.1681364","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T06:36:32Z","timestamp":1765434992000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of risk factor-based targeted nursing intervention on psychological status, sleep quality, and pain in patients with trigeminal neuralgia"],"prefix":"10.3389","volume":"16","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huayu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.ncl.2022.09.001","article-title":"Trigeminal neuralgia: diagnosis and treatment","volume":"41","author":"Allam","year":"2023","journal-title":"Neurol Clin"},{"key":"ref2","first-page":"427","article-title":"Trigeminal neuralgia: rapid evidence review","volume":"111","author":"Amaechi","year":"2025","journal-title":"Am Fam Physician"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e70051","DOI":"10.1111\/papr.70051","article-title":"Trigeminal Neuralgia","volume":"25","author":"Snel","year":"2025","journal-title":"Pain Pract"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1097\/j.pain.0000000000003428","article-title":"Trigeminal neuralgia and its comorbidities: a nationwide disease trajectory study","volume":"166","author":"Worm","year":"2025","journal-title":"Pain"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2174\/0113862073353707250204061916","article-title":"Evaluation of carbamazepine and gabapentin's safety and efficacy in trigeminal neuralgia treatment: a systematic review and meta-analysis","author":"Yang","year":"2025","journal-title":"Comb Chem High Throughput Screen"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"528","DOI":"10.3390\/jcm14020528","article-title":"Pathogenesis, diagnosis, and management of trigeminal neuralgia: a narrative review","volume":"14","author":"Liu","year":"2025","journal-title":"J Clin Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1007\/s10143-025-03556-4","article-title":"Psychological assessment in patients affected by trigeminal neuralgia. A systematic review","volume":"48","author":"Martinelli","year":"2025","journal-title":"Neurosurg Rev"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"110142","DOI":"10.1016\/j.jneumeth.2024.110142","article-title":"Neurorehabilitation strategies: assessing the impact on postoperative psychological state, pain, and complications in trigeminal neuralgia","volume":"407","author":"Wang","year":"2024","journal-title":"J Neurosci Methods"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s10194-025-02026-y","article-title":"Association between mental disorders and trigeminal neuralgia: a cohort study and mendelian randomization analysis","volume":"26","author":"Wang","year":"2025","journal-title":"J Headache Pain"},{"key":"ref10","first-page":"524","article-title":"Assessing the impact of a humanistic care-based nursing model on the psychological well-being of trigeminal neuralgia outpatients in pain clinics","volume":"29","author":"Gao","year":"2023","journal-title":"Altern Ther Health Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"e285","DOI":"10.1055\/s-0039-3402040","article-title":"Pain and psychological distress: effect of microvascular decompression on sleep disorders and obsessions in trigeminal neuralgia","volume":"82","author":"Wang","year":"2021","journal-title":"J Neurol Surg B Skull Base"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/bmsp.12389","article-title":"Effect sizes for experimental research","author":"Hedges","year":"2025","journal-title":"Br J Math Stat Psychol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/j.1469-185X.2007.00027.x","article-title":"Effect size, confidence interval and statistical significance: a practical guide for biologists","volume":"82","author":"Nakagawa","year":"2007","journal-title":"Biol Rev Camb Philos Soc"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"S37","DOI":"10.1016\/j.nrleng.2023.04.005","article-title":"Diagnosis and treatment of trigeminal neuralgia: consensus statement from the Spanish Society of Neurology's headache study group","volume":"38","author":"Latorre","year":"2023","journal-title":"Neurologia"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"5122","DOI":"10.1007\/s00415-024-12433-x","article-title":"Electroacupuncture and carbamazepine for patients with trigeminal neuralgia: a randomized, controlled, 2 \u00d7 2 factorial trial","volume":"271","author":"Li","year":"2024","journal-title":"J Neurol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"3921","DOI":"10.1007\/s00520-019-05244-8","article-title":"Hospital anxiety and depression scale (HADS) accuracy in cancer patients","volume":"28","author":"Annunziata","year":"2020","journal-title":"Support Care Cancer"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"3633","DOI":"10.2147\/JPR.S432842","article-title":"Trigeminal ganglion electrical stimulation for trigeminal nerve postherpetic neuralgia: a retrospective study","volume":"16","author":"Xu","year":"2023","journal-title":"J Pain Res"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41572-024-00523-z","article-title":"Trigeminal Neuralgia","volume":"10","author":"Ashina","year":"2024","journal-title":"Nat Rev Dis Primers"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"355","DOI":"10.3949\/ccjm.90a.22052","article-title":"Guidelines for the management of trigeminal neuralgia","volume":"90","author":"Chong","year":"2023","journal-title":"Cleve Clin J Med"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"987","DOI":"10.3171\/2025.2.JNS242655","article-title":"Development and validation of a predictive model for poor initial outcomes after gamma knife radiosurgery for trigeminal neuralgia: a prognostic correlative analysis","volume":"143","author":"Wang","year":"2025","journal-title":"J Neurosurg"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"E539","DOI":"10.36076\/ppj.2023.26.E539","article-title":"Outcomes and predictors of response to pregabalin for the treatment of post-traumatic trigeminal neuropathic pain following neuroablative procedures: a retrospective observational study","volume":"26","author":"Liu","year":"2023","journal-title":"Pain Physician"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e336","DOI":"10.1097\/j.pain.0000000000003616","article-title":"Sex-related differences in cannabidiol's antinociceptive efficacy in a trigeminal neuralgia rodent model","volume":"166","author":"Vivanco-Estela","year":"2025","journal-title":"Pain"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"4465","DOI":"10.1007\/s10072-023-06923-5","article-title":"Sex differences in trigeminal neuralgia: a focus on radiological and clinical characteristics","volume":"44","author":"De Stefano","year":"2023","journal-title":"Neurol Sci"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"e40318","DOI":"10.1097\/MD.0000000000040318","article-title":"Treatment of trigeminal neuralgia by acupuncture combined with Chinese medicine from the perspective of modern medicine: a review","volume":"103","author":"Liu","year":"2024","journal-title":"Medicine (Baltimore)"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.jocn.2023.12.019","article-title":"Clinical observation of perioperative negative emotional changes in patients with percutaneous balloon compression for primary trigeminal neuralgia: a prospective cohort study","volume":"120","author":"Tang","year":"2024","journal-title":"J Clin Neurosci"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1681364\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T06:36:33Z","timestamp":1765434993000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1681364\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,11]]},"references-count":25,"alternative-id":["10.3389\/fneur.2025.1681364"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2025.1681364","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,11]]},"article-number":"1681364"}}