{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T08:02:02Z","timestamp":1764230522015,"version":"3.46.0"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the current status and determinants of fatigue and to examine the relationship between fatigue and quality of life (QOL) in patients with neuromyelitis optica (NMO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eligible patients with NMO were assessed with the Fatigue Impact Scale (FIS) and the Chinese version of the Multiple Sclerosis Quality of Life-54 (MSQOL-54). Clinical factors influencing fatigue were explored and the association between fatigue and QOL was analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty-nine patients (mean age 40.13\u202fyears, male\/female 6\/63) were enrolled. The median Expanded Disability Status Scale (EDSS) score was 3, and 75.4% were seropositive for NMO-IgG. The total FIS score was 67.12\u202f\u00b1\u202f41.24, accounted for by the three sub-dimensions: cognitive fatigue 13.80\u202f\u00b1\u202f9.63, physical fatigue 20.48\u202f\u00b1\u202f12.93, and psychosocial fatigue 32.84\u202f\u00b1\u202f20.94. EDSS scores were positively correlated with total fatigue and all its subdomains; the number of relapses was positively correlated with cognitive fatigue; total fatigue and its subdomains were moderately and negatively correlated with all QOL dimensions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Disability status in NMO patients is associated with overall fatigue and its subdomains; relapse frequency is linked to cognitive fatigue; fatigue is negatively correlated with quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2025.1683353","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T07:57:07Z","timestamp":1764230227000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation between fatigue and quality of life among patients with neuromyelitis optica in West China"],"prefix":"10.3389","volume":"16","author":[{"given":"Xiaohui","family":"Miao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/S1474-4422(07)70216-8","article-title":"The spectrum of neuromyelitis optica","volume":"6","author":"Wingerchuk","year":"2007","journal-title":"Lancet Neurol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1212\/01.wnl.0000254502.87233.9a","article-title":"A secondary progressive clinical course is uncommon in neuromyelitis 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of fatigue across multiple sclerosis, aquaporin-4 antibody neuromyelitis optica spectrum disorder and MOG antibody disease","volume":"5","author":"Camera","year":"2023","journal-title":"Brain Commun"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"608149","DOI":"10.3389\/fneur.2021.608149","article-title":"Early treatment initiation with oral prednisolone for relapse prevention alleviates depression and fatigue in aquaporin-4-positive neuromyelitis optica spectrum disorder","volume":"12","author":"Akaishi","year":"2021","journal-title":"Front Neurol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1111\/j.1468-1331.2010.03252.x","article-title":"Evaluation of health-related quality of life, fatigue and depression in neuromyelitis optica","volume":"18","author":"Chanson","year":"2011","journal-title":"Eur J Neurol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1111\/cns.12411","article-title":"Hypoxemia, sleep 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