{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T07:45:35Z","timestamp":1788335135993,"version":"build-2803163510"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the clinical efficacy of percutaneous microballoon compression guided by three-dimensional digital subtraction angiography (DSA) navigation in treating primary trigeminal neuralgia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 40 patients with primary trigeminal neuralgia who underwent percutaneous microballoon compression under three-dimensional digital subtraction angiography navigation between January 2019 and April 2025. Post-operative pain relief was assessed 1 d, 1 month, and 3 months post-surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All 40 patients underwent three-dimensional digital subtraction angiography dual-volume imaging and 3D-Dyna-computed tomography cranial reconstruction at the pre-puncture, needle placement, balloon positioning, and balloon inflation stages. We adjusted the balloon morphology during inflation, considering cranial reconstruction and balloon positioning, for optimization. Post-operatively, all patients showed significant pain relief: 38 achieved immediate pain resolution, one resolved at 3 days, and one at 2 weeks. Overall, all 40 patients developed facial numbness, two developed perioral herpes, one developed diplopia, and one experienced transient masseter muscle weakness; all these resolved with treatment. Two patients showed recurrence during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Three-dimensional digital subtraction angiography navigation-guided percutaneous microballoon compression is a safe and minimally invasive technique for the treatment of trigeminal neuralgia. Real-time 3D-Dyna-computed tomography reconstruction enables the visualization of the balloon-petrous apex relationship, enhancing procedural precision and therapeutic outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2025.1686574","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T05:12:52Z","timestamp":1763615572000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy analysis of percutaneous balloon compression therapy for trigeminal neuralgia guided by three-dimensional digital subtraction angiography navigation"],"prefix":"10.3389","volume":"16","author":[{"given":"Zhennan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfa","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41572-024-00523-z","article-title":"Trigeminal neuralgia","volume":"10","author":"Ashina","year":"2024","journal-title":"Nat Rev Dis Primers."},{"key":"B2","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/S1474-4422(20)30233-7","article-title":"Advances in diagnosis, classification, pathophysiology, and management of trigeminal neuralgia","volume":"19","author":"Bendtsen","year":"2020","journal-title":"Lancet Neurol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.3171\/jns.1983.59.6.1007","article-title":"Percutaneous microcompression of the trigeminal ganglion for trigeminal neuralgia","volume":"59","author":"Mullan","year":"1983","journal-title":"J Neurosurg."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1007\/s40122-021-00311-7","article-title":"Prospective study to examine the association of the foramen ovale size with intraluminal pressure of pear-shaped balloon in percutaneous balloon compression for trigeminal neuralgia","volume":"10","author":"Wang","year":"2021","journal-title":"Pain Ther."},{"key":"B5","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1136\/neurintsurg-2013-010676","article-title":"Dyna-CT-assisted percutaneous microballoon compression for trigeminal neuralgia","volume":"6","author":"Huo","year":"2014","journal-title":"J Neurointervent Surg."},{"key":"B6","doi-asserted-by":"publisher","first-page":"108328","DOI":"10.1016\/j.clineuro.2024.108328","article-title":"Efficacy and safety of Dyna CT-assisted percutaneous balloon compression in the treatment of tumor-related trigeminal neuralgia: a single-center retrospective analysis","volume":"242","author":"Wang","year":"2024","journal-title":"Clin Neurol Neurosurg."},{"key":"B7","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1056\/NEJMra1914484","article-title":"Trigeminal neuralgia","volume":"383","author":"Cruccu","year":"2020","journal-title":"N Engl J Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1007\/s00415-020-10187-w","article-title":"Microvascular decompression for trigeminal neuralgia in the elderly: efficacy and safety","volume":"268","author":"Greve","year":"2021","journal-title":"J Neurol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s10194-022-01520-x","article-title":"Microvascular decompression in trigeminal neuralgia - a prospective study of 115 patients","volume":"23","author":"Andersen","year":"2022","journal-title":"J Headache Pain."},{"key":"B10","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1111\/ene.13950","article-title":"European Academy of Neurology guideline on trigeminal neuralgia","volume":"26","author":"Bendtsen","year":"2019","journal-title":"Eur J Neurol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1093\/pm\/pnac132","article-title":"Percutaneous radiofrequency ablation for trigeminal neuralgia management: a randomized, double-blinded, sham-controlled clinical trial","volume":"24","author":"Mansano","year":"2023","journal-title":"Pain Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"733","DOI":"10.3171\/2017.9.JNS17545","article-title":"Stereotactic radiosurgery for trigeminal neuralgia: a systematic review","volume":"130","author":"Tuleasca","year":"2019","journal-title":"J Neurosurg."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.3171\/2022.2.JNS212644","article-title":"Multivariate models to predict pain recurrence and sensitive complications after percutaneous balloon compression in trigeminal neuralgia","volume":"137","author":"Kourilsky","year":"2022","journal-title":"J Neurosurg."},{"key":"B14","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.2147\/JPR.S374433","article-title":"The focus and new progress of percutaneous balloon compression for the treatment of trigeminal neuralgia","volume":"15","author":"Xia","year":"2022","journal-title":"J Pain Res."},{"key":"B15","first-page":"E1255","article-title":"The analysis of percutaneous balloon compression on efficacy and negative emotion in the treatment of recurrent trigeminal neuralgia after surgical procedures","volume":"24","author":"Fan","year":"2021","journal-title":"Pain Physician."},{"key":"B16","doi-asserted-by":"publisher","first-page":"895394","DOI":"10.3389\/fsurg.2022.895394","article-title":"Combination of preoperative multimodal image fusion and intraoperative Dyna CT in percutaneous balloon compression of trigeminal ganglion for primary trigeminal neuralgia: experience in 24 patients","volume":"9","author":"Liao","year":"2022","journal-title":"Front Surg."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1007\/s10143-021-01649-4","article-title":"Percutaneous balloon compression technique using intraoperative contrasted DynaCT for the treatment of refractory trigeminal neuralgia: initial experience","volume":"45","author":"Jain","year":"2022","journal-title":"Neurosurg Rev."},{"key":"B18","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1177\/159101991301900314","article-title":"Percutaneous microballoon compression for trigeminal neuralgia using Dyna-CT","volume":"19","author":"Xiaochuan","year":"2013","journal-title":"Interv Neuroradiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1159\/000235805","article-title":"Dyna-CT as an imaging adjunct to routine percutaneous balloon compression for trigeminal neuralgia","volume":"87","author":"Van Gompel","year":"2009","journal-title":"Stereotact Funct Neurosurg."},{"key":"B20","doi-asserted-by":"publisher","first-page":"843982","DOI":"10.3389\/fsurg.2022.843982","article-title":"Clinical analysis of the treatment of primary trigeminal neuralgia by percutaneous balloon compression","volume":"9","author":"Wang","year":"2022","journal-title":"Front Surg."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1686574\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T05:12:53Z","timestamp":1763615573000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1686574\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,20]]},"references-count":20,"alternative-id":["10.3389\/fneur.2025.1686574"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2025.1686574","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,20]]},"article-number":"1686574"}}