{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:08:10Z","timestamp":1793344090070,"version":"4.5.0"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parkinson\u2019s disease (PD) is a neurodegenerative disorder characterized by progressive motor deficits and gait disturbances. While medication offers symptomatic relief, long-term complications and gradual functional decline remain significant challenges. Robot-assisted training provides intensive, task-specific motor rehabilitation and has shown promise in improving gait for PD patients. Soft wearable robot suits, designed with lightweight, flexible materials, offer enhanced comfort, adaptability, and biomechanical support compared to traditional robots. However, there is limited evidence regarding the effectiveness of hip extensor assistance with soft wearable robots for gait improvement in PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a prospective, single-center, single-blind, parallel-group study, and will recruit 34 PD patients. The participants will be assigned to either a robot or control group. Both groups will receive identical rehabilitation interventions, each session comprising 20-min of strength training, 5-min rest, and 20-min of treadmill walking. The rehabilitation program will be applied identically to all participants. The key difference between the groups will be whether participants wear the soft wearable robot suit during treadmill walking session. The intervention will be conducted 2 times per week, a total of 12 sessions for 6\u202fweeks. The H-Medi (HUROTICS, Inc.), a cable-driven soft wearable robot suit will be utilized for the intervention and hip extensor assistance will be applied. For outcome measures, the following assessments will be performed at baseline (T0) and post-intervention (T1): Gait speed, Timed-Up and Go test, Short Physical Performance Battery, Berg Balance Scale, Movement Disorder Society-Unified Parkinson\u2019s Disease Rating Scale, Freezing of Gait Questionnaire, gait parameters, muscle strength and endurance, quadriceps muscle thickness, body composition, cognition, and depression. The primary outcome will be the difference of gait speed from T0 to T1. The secondary outcomes will be the differences of other measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This study will be the first to assess hip extensor assistance provided by a soft wearable robot suit as a targeted therapy for gait impairment in PD. Results are expected to clarify device usability, safety, and impact on gait. By focusing on hip extension, the findings may help advance personalized gait rehabilitation and inform the design and clinical adoption of future wearable robotic devices for PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>KCT0010793.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2025.1695612","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T15:32:48Z","timestamp":1762356768000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of a soft wearable robot suit with hip extensor assistance on gait in patients with Parkinson\u2019s disease: a study protocol"],"prefix":"10.3389","volume":"16","author":[{"given":"Hyun Iee","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Chung-Ang University Hospital","place":["Seoul, Republic of Korea"]},{"name":"Department of Physical Medicine and Rehabilitation, College of Medicine, Chung-Ang University","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Chung-Ang University Hospital","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na Young","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Chung-Ang University Hospital","place":["Seoul, Republic of Korea"]},{"name":"Department of Physical Medicine and Rehabilitation, College of Medicine, Chung-Ang University","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haerin","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Chung-Ang University Hospital","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeongmin","family":"Lim","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, Chung-Ang University","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Chan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Chung-Ang University Hospital","place":["Seoul, Republic of Korea"]},{"name":"Department of Physical Medicine and Rehabilitation, College of Medicine, Chung-Ang University","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Jun","family":"Park","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, Chung-Ang University","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, Chung-Ang University","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeong Jun","family":"Cho","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, Chung-Ang University","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuk","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, Chung-Ang University","place":["Seoul, Republic of Korea"]},{"name":"HUROTICS Inc.","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don-Kyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, College of Medicine, Chung-Ang University","place":["Seoul, Republic of Korea"]},{"name":"Department of Physical Medicine and Rehabilitation, Chung-Ang University Gwangmyeong Hospital","place":["Gwangmyeong-si, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson's 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