{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:54:34Z","timestamp":1776560074744,"version":"3.51.2"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Insomnia is a common comorbid symptom in Parkinson\u2019s disease (PD) patients, significantly impairing their quality of life. Acupuncture is widely applied in treating PD insomnia, yet relevant evidence remains fragmented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the efficacy of acupuncture in improving PD insomnia through systematic review and meta-analysis, evaluating its clinical effectiveness and safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eight electronic databases were searched: PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), VIP Data Platform, Wanfang Data Knowledge Service Platform, and China Biomedical Literature Service System. References from relevant literature and clinical trial registries were manually searched for randomized controlled trials (RCTs) on acupuncture for PD insomnia. Studies were screened against inclusion and exclusion criteria, relevant data extracted, and meta-analysis conducted using RevMan 5.4 software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eleven studies involving 800 patients were included. Meta-analysis revealed that acupuncture effectively improved PSQI (MD\u202f=\u202f\u22122.87, 95% CI: \u22124.28 to \u22121.46,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.0001) and PDSS (MD\u202f=\u202f7.96, 95% CI: 5.55\u201310.37,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.00001), demonstrating superior efficacy compared to the control group (MD\u202f=\u202f6.64, 95% CI: 3.47\u201312.69,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.00001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Acupuncture effectively improves PSQI and PDSS scores in patients with PD insomnia and exhibits superior efficacy over the control group. However, due to limitations, further details could not be explored.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2025.1697481","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:22:09Z","timestamp":1762147329000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The efficacy and safety of acupuncture for Parkinson\u2019s disease insomnia: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"16","author":[{"given":"Yujie","family":"Gu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huichao","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuncheng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/S1474-4422(21)00030-2","article-title":"Challenges in the diagnosis of Parkinson\u2019s disease","volume":"20","author":"Tolosa","year":"2021","journal-title":"Lancet Neurol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson\u2019s disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","article-title":"Ageing as a risk factor for neurodegenerative disease","volume":"15","author":"Hou","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1007\/s13311-020-00964-w","article-title":"Approaches to disease modification for Parkinson\u2019s disease: clinical trials and lessons learned","volume":"17","author":"Hung","year":"2020","journal-title":"Neurotherapeutics"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.parkreldis.2017.07.020","article-title":"The 200-year journey of Parkinson disease: reflecting on the past and looking towards the future","volume":"46","author":"Fahn","year":"2018","journal-title":"Parkinsonism Relat Disord"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1093\/brain\/114.5.2283","article-title":"Ageing and Parkinson\u2019s disease: substantia nigra regional selectivity","volume":"114","author":"Fearnley","year":"1991","journal-title":"Brain"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.3390\/life15081169","article-title":"The search for disease modification in Parkinson\u2019s disease-a review of the literature","volume":"15","author":"Barber","year":"2025","journal-title":"Life"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/bs.irn.2017.05.033","article-title":"Sleep dysfunction in Parkinson\u2019s disease","volume":"133","author":"Falup-Pecurariu","year":"2017","journal-title":"Int Rev Neurobiol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.3390\/brainsci13081202","article-title":"Neurological insights into sleep disorders in Parkinson\u2019s disease","volume":"13","author":"Thangaleela","year":"2023","journal-title":"Brain Sci"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.2174\/1570159X19666210517115706","article-title":"Pharmacological and non-pharmacological treatments of sleep disorders in Parkinson\u2019s disease","volume":"19","author":"Taximaimaiti","year":"2021","journal-title":"Curr Neuropharmacol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1080\/14656566.2024.2422004","article-title":"Pharmacological and non-pharmacological management of sleep disturbances in Parkinson\u2019s disease: if when and how","volume":"25","author":"Falup-Pecurariu","year":"2024","journal-title":"Expert Opin Pharmacother"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/s41386-019-0448-y","article-title":"Sleep in Parkinson\u2019s disease","volume":"45","author":"Stefani","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1080\/14737175.2025.2450789","article-title":"Managing sleep issues in Parkinson\u2019s disease: an up-to-date review","volume":"25","author":"Suzuki","year":"2025","journal-title":"Expert Rev Neurother"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.gerinurse.2016.11.010","article-title":"The use of acupuncture in patients with Parkinson\u2019s disease","volume":"38","author":"Cheng","year":"2017","journal-title":"Geriatric Nurs"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"721","DOI":"10.13703\/j.0255-2930.20200704-k0001","article-title":"Effect of Tongdu Tiaoshen acupuncture on serum GABA and CORT levels in patients with chronic insomnia","volume":"41","author":"Wu","year":"2021","journal-title":"Zhongguo zhen jiu"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1038945","DOI":"10.3389\/fnins.2022.1038945","article-title":"The autonomic nervous system: a potential link to the efficacy of acupuncture","volume":"16","author":"Li","year":"2022","journal-title":"Front Neurosci"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e12574","DOI":"10.1016\/j.heliyon.2022.e12574","article-title":"Baihui (DU20), Shenmen (HT7) and Sanyinjiao (SP6) target the cAMP\/CREB\/BDNF and PI3K\/Akt pathways to reduce central nervous system apoptosis in rats with insomnia","volume":"8","author":"Cao","year":"2022","journal-title":"Heliyon"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jams.2016.12.007","article-title":"Acupuncture as adjuvant therapy for sleep disorders in Parkinson\u2019s disease","volume":"10","author":"Aroxa","year":"2017","journal-title":"J Acupunct Meridian Stud"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"101083","DOI":"10.1016\/j.imr.2024.101083","article-title":"Reducing Parkinson\u2019s disease incidence in patients with insomnia through acupuncture: a cohort study","volume":"13","author":"Huang","year":"2024","journal-title":"Int Med Res"},{"key":"ref20","first-page":"506","article-title":"Clinical observation of 56 cases of acupuncture treatment for Parkinson\u2019s disease with insomnia","volume":"28","author":"Bai","year":"2021","journal-title":"Chin J Tradit Med Sci Technol"},{"key":"ref21","first-page":"469","article-title":"Clinical observation on the combined use of modified Guipi decoction and acupuncture for insomnia in Parkinson\u2019s disease with deficiency of both heart and spleen","volume":"21","author":"Chen","year":"2021","journal-title":"World Latest Med Inform"},{"key":"ref22","first-page":"214","article-title":"A randomized controlled trial of transcranial direct current stimulation for sleep disorders in Parkinson\u2019s disease","volume":"15","author":"Dong","year":"2018","journal-title":"Practi J Clin Med"},{"key":"ref23","first-page":"348","article-title":"Clinical observation of fang\u2019s scalp acupuncture in treating insomnia associated with Parkinson\u2019s disease","volume":"35","author":"Huang","year":"2014","journal-title":"Shaanxi J Tradit Chin Med"},{"key":"ref24","first-page":"2043","article-title":"Clinical observation on Guipi decoction combined with acupuncture and Moxibustion in the treatment of insomnia patients with Parkinson","volume":"33","author":"Li","year":"2018","journal-title":"Guangming Journal of Chinese Medicine"},{"key":"ref25","first-page":"113","article-title":"Clinical study on electroacupuncture combined with Madopar for sleep disorders in Parkinson disease","volume":"53","author":"Li","year":"2021","journal-title":"New Chinese Med"},{"key":"ref26","first-page":"55","article-title":"15 cases of sleep disorder of Parkinson\u2019s disease treated with acupuncture combined with psychotherapy","volume":"31","author":"Li","year":"2019","journal-title":"J Jiangxi Univ Chin Med"},{"key":"ref27","first-page":"103","article-title":"Clinical efficacy study of acupuncture treatment for sleep disorders in Parkinson\u2019s disease","volume":"12","author":"Wang","year":"2024","journal-title":"Chin Sci Technol J Database"},{"key":"ref28","first-page":"82","article-title":"Effects of Tongdu Jieyu acupuncture combined with Bushen Zhichan prescription and levodopa and Benserazide hydrochloride tablets in treatment of patients with Parkinson\u2019s disease with sleep disorders","volume":"36","author":"Zhao","year":"2024","journal-title":"Med J Chin Peoples Health"},{"key":"ref29","first-page":"3253","article-title":"Clinical observation on the treatment of insomnia in Parkinson\u2019s disease with heart-spleen deficiency pattern using modified Guipi decoction combined with acupuncture","volume":"35","author":"Zhu","year":"2020","journal-title":"Guangming J Chin Med"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"2469","DOI":"10.1007\/s00415-021-10812-2","article-title":"Associations of sleep disorders with cerebrospinal fluid \u03b1-synuclein in prodromal and early Parkinson\u2019s disease","volume":"269","author":"Wang","year":"2022","journal-title":"J Neurol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/nrn.2017.62","article-title":"Non-motor features of Parkinson disease","volume":"18","author":"Schapira","year":"2017","journal-title":"Nat Rev Neurosci"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1177\/09645284211041125","article-title":"Acupuncture for rapid eye movement sleep behavior disorder in Parkinson\u2019s disease: a case report","volume":"40","author":"Li","year":"2022","journal-title":"Acupunct Med"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1640389","DOI":"10.3389\/fnagi.2025.1640389","article-title":"Acupuncture modulates the microbiota-gut-brain axis: a new strategy for Parkinson\u2019s disease treatment","volume":"17","author":"Zang","year":"2025","journal-title":"Front Aging Neurosci"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1142\/S0192415X19500277","article-title":"Acupuncture inhibits the increase in alpha-Synuclein by modulating SGK1 in an MPTP induced parkinsonism mouse model","volume":"47","author":"Yeo","year":"2019","journal-title":"Am J Chin Med"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"e13213","DOI":"10.1111\/cpr.13213","article-title":"In situ analysis of acupuncture protecting dopaminergic neurons from lipid peroxidative damage in mice of Parkinson\u2019s disease","volume":"55","author":"Zuo","year":"2022","journal-title":"Cell Prolif"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.bbi.2020.08.015","article-title":"Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson\u2019s disease","volume":"89","author":"Jang","year":"2020","journal-title":"Brain Behav Immun"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1093\/sleep\/29.9.1155","article-title":"Recommendations for a standard research assessment of insomnia","volume":"29","author":"Buysse","year":"2006","journal-title":"Sleep"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"e768","DOI":"10.4088\/JCP.14m09066","article-title":"Exploring the construct of subjective sleep quality in patients with insomnia","volume":"76","author":"Hartmann","year":"2015","journal-title":"J Clin Psychiatry"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Res"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/S0022-3999(97)00298-5","article-title":"Psychometric evaluation of the Pittsburgh sleep quality index","volume":"45","author":"Carpenter","year":"1998","journal-title":"J Psychosom Res"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1093\/sleep\/23.2.1l","article-title":"Evaluation of chronic insomnia. An American Academy of sleep medicine review","volume":"23","author":"Sateia","year":"2000","journal-title":"Sleep"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1136\/jnnp.73.6.629","article-title":"The Parkinson\u2019s disease sleep scale: a new instrument for assessing sleep and nocturnal disability in Parkinson\u2019s disease","volume":"73","author":"Chaudhuri","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"2704","DOI":"10.1002\/mds.23190","article-title":"Scales to assess sleep impairment in Parkinson\u2019s disease: critique and recommendations","volume":"25","author":"H\u00f6gl","year":"2010","journal-title":"Mov Disord"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"e36286","DOI":"10.1097\/MD.0000000000036286","article-title":"Acupuncture and sleep disorders in Parkinson\u2019s disease: a systematic evaluation with meta-analysis","volume":"103","author":"Yan","year":"2024","journal-title":"Medicine"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"103044","DOI":"10.1016\/j.ctim.2024.103044","article-title":"Efficacy of acupuncture as adjunct therapy for sleep disorders in Parkinson\u2019s disease: a systematic review and meta-analysis","volume":"82","author":"Mi","year":"2024","journal-title":"Complement Ther Med"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1697481\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:22:11Z","timestamp":1762147331000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1697481\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,3]]},"references-count":45,"alternative-id":["10.3389\/fneur.2025.1697481"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2025.1697481","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,3]]},"article-number":"1697481"}}