{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T05:24:59Z","timestamp":1765430699460,"version":"3.46.0"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"\n Background<\/jats:title>\n People with multiple sclerosis (MS) often present with chronic comorbidities that complicate care and affect prognosis. Population-based evidence in Europe is limited.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To describe the prevalence of selected comorbidities among individuals with MS in Catalonia, Spain, using administrative health records.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We analysed data from 9,998 people diagnosed with MS (2013\u20132017), including demographic and diagnostic information across all care levels. Prevalence estimates for 23 comorbidities were stratified by age and sex, and, where available, compared with those of the general population.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The MS population had a higher prevalence of psychiatric, metabolic, and autoimmune comorbidities in all age groups. Young women (18\u201340\u2009years) showed increased rates of depression, anxiety, thyroid disease, and migraine, while middle-aged men (50\u201360\u2009years) had higher rates of hypertension, hyperlipidaemia, and diabetes.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n MS is associated with a substantial, early-onset comorbidity burden, underscoring the need for integrated, multidisciplinary care across the life course.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fneur.2025.1699641","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T05:20:06Z","timestamp":1765430406000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Burden of comorbidities in people with multiple sclerosis: a population-based study in Catalonia"],"prefix":"10.3389","volume":"16","author":[{"given":"Toni","family":"Mora","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1177\/1352458514564491","article-title":"A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis: overview","volume":"21","author":"Marrie","year":"2015","journal-title":"Mult Scler"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1177\/1352458520970841","article-title":"Rising prevalence of multiple sclerosis worldwide: insights from the Atlas of MS, third edition","volume":"26","author":"Walton","year":"2020","journal-title":"Mult Scler"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1056\/NEJMra1401483","article-title":"Multiple Sclerosis","volume":"378","author":"Reich","year":"2018","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1177\/1352458508099477","article-title":"The burden of mental comorbidity in multiple sclerosis: frequent, underdiagnosed, and under-treated","volume":"15","author":"Marrie","year":"2009","journal-title":"Mult Scler"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.msard.2015.07.014","article-title":"Comorbidity is associated with pain-related activity limitations in multiple sclerosis","volume":"4","author":"Fiest","year":"2015","journal-title":"Mult Scler Relat Disord"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e1435","DOI":"10.1212\/WNL.0000000000005331","article-title":"Temporal trends in multiple sclerosis prevalence and incidence in a large population","volume":"90","author":"Rotstein","year":"2018","journal-title":"Neurology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.nrl.2023.06.006","article-title":"Prevalence of multiple sclerosis in Spain: estimates from the Primary Care Clinical Database (BDCAP)","volume":"40","author":"Cayuela","year":"2025","journal-title":"Neurologia"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"4124","DOI":"10.1111\/ene.15030","article-title":"Multiple sclerosis is associated with higher comorbidity and health care resource use: A population-based, case-control study in a western Mediterranean region","volume":"28","author":"C\u00e1rdenas-Robledo","year":"2021","journal-title":"Eur J Neurol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1136\/jnnp-2016-315238","article-title":"Survival and cause of death in multiple sclerosis: a 60-year longitudinal study","volume":"88","author":"Lunde","year":"2017","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1699641\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T05:20:07Z","timestamp":1765430407000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1699641\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,11]]},"references-count":9,"alternative-id":["10.3389\/fneur.2025.1699641"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2025.1699641","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,11]]},"article-number":"1699641"}}