{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:34:15Z","timestamp":1787495655761,"version":"build-2736575974"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate urodynamic characteristics, identify high-risk and unfavorable urodynamic findings in children with neurogenic lower urinary tract dysfunction (NLUTD) secondary to Guillain-Barre syndrome (GBS) within 6\u2009months since the onset of illness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study conducted a retrospective observational analysis of 16 children diagnosed with GBS complicated by NLUTD. Clinical data collected included demographic information, lower urinary tract symptoms, uroflowmetry results, post-void residual urine (PVRU), and urodynamic parameters. Follow-up assessments focused on high-risk urodynamic features-such as high detrusor pressure during the filling phase and low bladder compliance-as well as unfavorable findings, including detrusor overactivity, detrusor underactivity, or an acontractile bladder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The majority of patients presented with clinical symptoms of urinary retention. Characterized by a decreased Qmax on uroflowmetry and elevated PVRU. Urodynamic study (UDS) revealed two predominant findings: reduced bladder sensation during the filling phase and detrusor underactivity during the voiding phase. At the 8-week follow-up, low bladder compliance and detrusor overactivity were observed in only 2 of the 16 patients (12.5%). During the filling phase, none of the patients exhibited high detrusor pressure (&amp;gt;40 cmH\u2082O), while all cases demonstrated underactive bladder function during the voiding phase. By the 24-week follow-up, 12 patients (12\/16, 75.0%) had achieved normal bladder compliance, with only one case persisting with low bladder compliance and detrusor overactivity. Additionally, 10 patients (10\/16, 62.5%) who had presented with an underactive bladder during the voiding phase showed recovery by the 24-week assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prognosis of autonomic dysfunction involving the urinary system in pediatric GBS was generally favorable, with most cases of GBS-associated NLUTS showing substantial reversibility, as confirmed by the normalization of urodynamic parameters over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2025.1706698","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T05:12:30Z","timestamp":1765170750000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Urodynamic evaluation of neurogenic lower urinary tract dysfunction in children with Guillain-Barre syndrome within 6\u2009months"],"prefix":"10.3389","volume":"16","author":[{"given":"Yan","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naixi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"3646","DOI":"10.1111\/jns.12594","article-title":"European academy of neurology\/peripheral nerve society guideline on diagnosis and treatment of Guillain\u2013Barr\u00e9 syndrome","volume":"30","author":"Doorn","year":"2023","journal-title":"J Peripher Nerv Syst"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/S0140-6736(16)00339-1","article-title":"Guillain-Barr\u00e9 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dysfunction in Guillain-Barre syndrome","volume":"28","author":"Sakakibara","year":"2009","journal-title":"Neurourol Urodyn"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1177\/0883073811420872","article-title":"Autonomic dysfunction in childhood Guillain-Barr\u00e9 syndrome","volume":"27","author":"Dimario","year":"2012","journal-title":"J Child Neurol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"S50","DOI":"10.1002\/nau.23773","article-title":"Fundamentals of urodynamic practice, based on international continence society good urodynamic practices recommendations","volume":"37","author":"Drake","year":"2018","journal-title":"Neurourol Urodyn"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1097\/JU.0000000000002235","article-title":"The AUA\/SUFU guideline on adult neurogenic lower urinary tract dysfunction: diagnosis and evaluation","volume":"206","author":"Ginsberg","year":"2021","journal-title":"J Urol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.eururo.2015.07.071","article-title":"Summary of European Association of Urology (EAU) guidelines on neuro-urology","volume":"69","author":"Groen","year":"2016","journal-title":"Eur Urol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1002\/nau.22751","article-title":"The standardization of terminology of lower urinary tract function in children and adolescents: update report from the standardization committee of the international children\u2019s continence society","volume":"35","author":"Austin","year":"2016","journal-title":"Neurourol Urodyn"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1002\/nau.23124","article-title":"International continence society good urodynamic practices and terms 2016: urodynamics, uroflowmetry, cystometry, and pressure-flow study","volume":"36","author":"Rosier","year":"2017","journal-title":"Neurourol Urodyn"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e123588","DOI":"10.1016\/j.jns.2025.123588","article-title":"Predictors of poor prognosis in Guillain-Barre' syndrome: a study of 22 years from a single Italian center","volume":"475","author":"Ariatti","year":"2025","journal-title":"J Neurol Sci"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1007\/s13312-021-2302-7","article-title":"Clinical outcome of Guillain-Barr\u00e9 syndrome in 108 children","volume":"58","author":"Sen","year":"2021","journal-title":"Indian Pediatr"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e16346","DOI":"10.1111\/ene.16346","article-title":"Guillain-Barr\u00e9 syndrome: history, pathogenesis, treatment, and future directions","volume":"31","author":"Hughes","year":"2024","journal-title":"Eur Neurol"}],"container-title":["Frontiers in 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