{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T05:20:37Z","timestamp":1764566437941,"version":"3.46.0"},"reference-count":139,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Migraine is a prevalent and highly disabling neurological disorder. A systematic evaluation of its foundational literature is essential for advancing management strategies. This study employed bibliometric methods to trace the historical trajectory of migraine research and identify principal developmental trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Web of Science and PubMed database was searched to identify the 200 most highly cited publications, filtered by date, language, and document type. Comprehensive analyses and visualizations were conducted using bibliometrix (R), VOSviewer, Scimago Graphica, CiteSpace, and Microsoft Excel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The selected publications appeared in 45 journals across 45 countries, authored by 4,409 researchers from 1,592 institutions. Together, these works incorporated 860 keywords and cited 7,995 references. Neurology, Cephalalgia, and Headache were the leading journals, while Lipton RB and Goadsby PJ were the most influential authors. The United States led in publication volume, with Albert Einstein College of Medicine among the top institutions. Ten landmark papers were highlighted, and their contributions, along with those of the broader corpus, were systematically reviewed. Key research hotspots were also delineated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Current high-impact research emphasizes treatment, therapeutic targets, genetics, the trigeminovascular system, pain modulation, neuroimmunology, aura, and comorbidities. Recent studies confirm sustained interest in these areas, with increasing focus on the brain\u2013gut axis. Future directions include deeper investigation of migraine pathophysiology, especially the calcitonin gene-related peptide system and episodic migraine subtypes. Rigorous methodologies and emerging technologies will enhance evidence-based evaluations of long-term safety and efficacy, while multidimensional assessments of pharmacological and non-pharmacological therapies are expected to expand.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2025.1711571","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T05:16:34Z","timestamp":1764566194000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The 200 most influential publications in migraine research: a bibliometric mapping of the intellectual landscape"],"prefix":"10.3389","volume":"16","author":[{"given":"Qianxiu","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shijie","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoliang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengcheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1016\/S0140-6736(17)32154-2","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the global burden of disease study 2016","volume":"390","year":"2017","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1111\/j.1468-1331.2011.03612.x","article-title":"The cost of headache disorders in Europe: the Eurolight project","volume":"19","author":"Linde","year":"2012","journal-title":"Eur J Neurol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00005-009-0001-5","article-title":"New developments in the use of citation analysis in research evaluation","volume":"57","author":"Moed","year":"2009","journal-title":"Arch Immunol Ther Exp"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"296","DOI":"10.4103\/1008-682X.171582","article-title":"Bibliometrics: tracking research impact by selecting the appropriate metrics","volume":"18","author":"Agarwal","year":"2016","journal-title":"Asian J Androl"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e58494","DOI":"10.3791\/58494","article-title":"Comparing bibliometric analysis using PubMed, Scopus, and web of science databases","author":"AlRyalat","year":"2019","journal-title":"JoVE"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"16","DOI":"10.5195\/jmla.2019.433","article-title":"Exploring PubMed as a reliable resource for scholarly communications services","volume":"107","author":"Ossom Williamson","year":"2019","journal-title":"J Med Libr Assoc"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1007\/s11192-020-03647-7","article-title":"Sample size in bibliometric analysis","volume":"125","author":"Rogers","year":"2020","journal-title":"Scientometrics"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"103197","DOI":"10.1016\/j.xpro.2024.103197","article-title":"Protocol for isolating and identifying small extracellular vesicles derived from human umbilical cord mesenchymal stem cells","volume":"5","author":"Chen","year":"2024","journal-title":"STAR Protocols"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"854","DOI":"10.21037\/atm-22-913","article-title":"A bibliometric analysis of the application of artificial intelligence to advance individualized diagnosis and treatment of critical illness","volume":"10","author":"Liu","year":"2022","journal-title":"Ann Transl Med"},{"key":"ref10","author":"Egghe","year":"2006"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"e65","DOI":"10.7417\/CT.2017.1985","article-title":"New bibliometric indicators for the scientific literature: an evolving panorama","volume":"168","author":"La Torre","year":"2017","journal-title":"Clin Ter"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"104047","DOI":"10.1016\/j.jbi.2022.104047","article-title":"A probabilistic model for co-occurrence analysis in bibliometrics","volume":"128","author":"Zhou","year":"2022","journal-title":"J Biomed Inform"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"145614","DOI":"10.1109\/ACCESS.2019.2945911","article-title":"Two-stage topic extraction model for bibliometric data analysis based on word embeddings and clustering","volume":"7","author":"Onan","year":"2019","journal-title":"IEEE Access"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1002\/asi.4630240406","article-title":"Co-citation in the scientific literature: a new measure of the relationship between two documents","volume":"24","author":"Small","year":"1973","journal-title":"J Am Soc Inf Sci"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1517\/14712598.2012.674507","article-title":"Emerging trends in regenerative medicine: a scientometric analysis in CiteSpace","volume":"12","author":"Chen","year":"2012","journal-title":"Expert Opin Biol Ther"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1177\/0165551504042802","article-title":"Historiographic mapping of knowledge domains literature","volume":"30","author":"Garfield","year":"2004","journal-title":"J Inf Sci"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.joi.2017.08.007","article-title":"Bibliometrix: an R-tool for comprehensive science mapping analysis","volume":"11","author":"Aria","year":"2017","journal-title":"J Informetr"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s11192-009-0146-3","article-title":"Software survey: VOSviewer, a computer program for bibliometric mapping","volume":"84","author":"van Eck","year":"2010","journal-title":"Scientometrics"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3145\/epi.2022.sep.02","article-title":"Scimago graphica: a new tool for exploring and visually communicating data","volume":"31","author":"Hassan-Montero","year":"2022","journal-title":"Prof Inferm"},{"key":"ref20","first-page":"724","article-title":"CiteSpace II: visualization and knowledge discovery in bibliographic databases","volume":"2005","author":"Synnestvedt","year":"2005","journal-title":"AMIA Annu Symp Proc"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1468-2982.2004.00892.x","article-title":"Migraine pathophysiology and its clinical implications","volume":"24","author":"Silberstein","year":"2004","journal-title":"Cephalalgia"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/0333102417738202","article-title":"The international classification of headache disorders, 3rd edition","volume":"38","year":"2018","journal-title":"Cephalalgia"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1177\/0333102413485658","article-title":"The international classification of headache disorders, 3rd edition (beta version)","volume":"33","year":"2013","journal-title":"Cephalalgia"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1177\/0333102410364677","article-title":"OnabotulinumtoxinA for treatment of chronic migraine: results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 2 trial","volume":"30","author":"Diener","year":"2010","journal-title":"Cephalalgia"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/s41582-018-0003-1","article-title":"CGRP as the target of new migraine therapies - successful translation from bench to clinic","volume":"14","author":"Edvinsson","year":"2018","journal-title":"Nat Rev Neurol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/nn.2475","article-title":"A neural mechanism for exacerbation of headache by light","volume":"13","author":"Noseda","year":"2010","journal-title":"Nat Neurosci"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1038\/ng.652","article-title":"Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1","volume":"42","author":"Anttila","year":"2010","journal-title":"Nat Genet"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1038\/nm.2216","article-title":"A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura","volume":"16","author":"Lafreni\u00e8re","year":"2010","journal-title":"Nat Med"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1016\/S0140-6736(00)04250-1","article-title":"Brainstem activation specific to migraine headache","volume":"357","author":"Bahra","year":"2001","journal-title":"Lancet"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1056\/NEJMoa030505","article-title":"Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine","volume":"350","author":"Olesen","year":"2004","journal-title":"N Engl J Med"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1046\/j.1468-2982.2002.00310.x","article-title":"CGRP may play a causative role in migraine","volume":"22","author":"Lassen","year":"2002","journal-title":"Cephalalgia"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/nm0202-136","article-title":"Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model","volume":"8","author":"Bolay","year":"2002","journal-title":"Nat Med"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"4687","DOI":"10.1073\/pnas.071582498","article-title":"Mechanisms of migraine aura revealed by functional MRI in human visual cortex","volume":"98","author":"Hadjikhani","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1212\/01.wnl.0000252808.97649.21","article-title":"Migraine prevalence, disease burden, and the need for preventive therapy","volume":"68","author":"Lipton","year":"2007","journal-title":"Neurology"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1056\/NEJMra010917","article-title":"Migraine--current understanding and treatment","volume":"346","author":"Goadsby","year":"2002","journal-title":"N Engl J Med"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1046\/j.1526-4610.2001.041007646.x","article-title":"Prevalence and burden of migraine in the United States: data from the American migraine study II","volume":"41","author":"Lipton","year":"2001","journal-title":"Headache"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1212\/WNL.53.3.537","article-title":"The prevalence and characteristics of migraine in a population-based cohort: the GEM study","volume":"53","author":"Launer","year":"1999","journal-title":"Neurology"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/S0140-6736(05)66786-4","article-title":"Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine","volume":"366","author":"Dichgans","year":"2005","journal-title":"Lancet"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1016\/S0140-6736(01)06711-3","article-title":"Oral triptans (serotonin 5-HT(1B\/1D) agonists) in acute migraine treatment: a meta-analysis of 53 trials","volume":"358","author":"Ferrari","year":"2001","journal-title":"Lancet"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1111\/j.1468-2982.2006.01172.x","article-title":"New appendix criteria open for a broader concept of chronic migraine","volume":"26","author":"Olesen","year":"2006","journal-title":"Cephalalgia"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"CD001218","DOI":"10.1002\/14651858.CD001218.pub2","article-title":"Acupuncture for migraine prophylaxis","volume":"1","author":"Linde","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1111\/j.1468-2982.2009.01941.x","article-title":"Global prevalence of chronic migraine: a systematic review","volume":"30","author":"Natoli","year":"2010","journal-title":"Cephalalgia"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1001\/jama.293.17.2118","article-title":"Acupuncture for patients with migraine: a randomized controlled trial","volume":"293","author":"Linde","year":"2005","journal-title":"JAMA"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/S1474-4422(06)70382-9","article-title":"Efficacy of acupuncture for the prophylaxis of migraine: a multicentre randomized controlled clinical trial","volume":"5","author":"Diener","year":"2006","journal-title":"Lancet Neurol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/S1474-4422(14)70128-0","article-title":"Safety and efficacy of LY2951742, a monoclonal antibody to calcitonin gene-related peptide, for the prevention of migraine: a phase 2, randomised, double-blind, placebo-controlled study","volume":"13","author":"Dodick","year":"2014","journal-title":"Lancet Neurol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1056\/NEJMoa1705848","article-title":"A controlled trial of erenumab for episodic migraine","volume":"377","author":"Goadsby","year":"2017","journal-title":"N Engl J Med"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1212\/WNL.53.5.988","article-title":"An international study to assess reliability of the migraine disability assessment (MIDAS) score","volume":"53","author":"Stewart","year":"1999","journal-title":"Neurology"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1046\/j.1526-4610.1998.3802087.x","article-title":"Medical consultation for migraine: results from the American migraine study","volume":"38","author":"Lipton","year":"1998","journal-title":"Headache"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1002\/ana.22329","article-title":"Activation of central trigeminovascular neurons by cortical spreading depression","volume":"69","author":"Zhang","year":"2011","journal-title":"Ann Neurol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/S1474-4422(15)00249-5","article-title":"Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of high-frequency episodic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study","volume":"14","author":"Bigal","year":"2015","journal-title":"Lancet Neurol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/S1474-4422(15)00245-8","article-title":"Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of chronic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study","volume":"14","author":"Bigal","year":"2015","journal-title":"Lancet Neurol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1177\/0333102416653233","article-title":"A phase IIb randomized, double-blind, placebo-controlled trial of ubrogepant for the acute treatment of migraine","volume":"36","author":"Voss","year":"2016","journal-title":"Cephalalgia"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1038\/ng.2676","article-title":"Genome-wide meta-analysis identifies new susceptibility loci for migraine","volume":"45","author":"Anttila","year":"2013","journal-title":"Nat Genet"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1126\/science.1231897","article-title":"Spreading depression triggers headache by activating neuronal Panx1 channels","volume":"339","author":"Karatas","year":"2013","journal-title":"Science"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1056\/NEJM200107053450103","article-title":"The clinical spectrum of familial hemiplegic migraine associated with mutations in a neuronal calcium channel","volume":"345","author":"Ducros","year":"2001","journal-title":"N Engl J Med"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1001\/jama.291.4.427","article-title":"Migraine as a risk factor for subclinical brain lesions","volume":"291","author":"Kruit","year":"2004","journal-title":"JAMA"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1093\/brain\/123.8.1703","article-title":"The development of cutaneous allodynia during a migraine attack clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine","volume":"123","author":"Burstein","year":"2000","journal-title":"Brain"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"4588","DOI":"10.1111\/bph.15657","article-title":"Pharmacological treatment of migraine: drug classes, mechanisms of action, clinical trials and new treatments","volume":"178","author":"Zobdeh","year":"2021","journal-title":"Br J Pharmacol"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1142\/S0192415X20500019","article-title":"Effects of herbal medicines on pain management","volume":"48","author":"Luo","year":"2020","journal-title":"Am J Chin Med"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.1038\/s41380-024-02624-3","article-title":"Effects and safety of transcranial direct current stimulation on multiple health outcomes: an umbrella review of randomized clinical trials","volume":"29","author":"Kang","year":"2024","journal-title":"Mol Psychiatry"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"e315","DOI":"10.1097\/SLA.0000000000005057","article-title":"Efficacy and safety of migraine surgery: a systematic review and meta-analysis of outcomes and complication rates","volume":"275","author":"ElHawary","year":"2022","journal-title":"Ann Surg"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/bph.15710","article-title":"5-hydroxytryptamine in migraine: the puzzling role of ionotropic 5-HT3 receptor in the context of established therapeutic effect of metabotropic 5-HT1 subtypes","volume":"179","author":"Giniatullin","year":"2022","journal-title":"Br J Pharmacol"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/s41582-023-00842-x","article-title":"The 5-HT1F receptor as the target of ditans in migraine - from bench to bedside","volume":"19","author":"Mitsikostas","year":"2023","journal-title":"Nat Rev Neurol"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.npep.2013.10.010","article-title":"CGRP and migraine: could PACAP play a role too?","volume":"47","author":"Kaiser","year":"2013","journal-title":"Neuropeptides"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s10194-023-01569-2","article-title":"Shared and independent roles of CGRP and PACAP in migraine pathophysiology","volume":"24","author":"Kuburas","year":"2023","journal-title":"J Headache Pain"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1177\/0333102413483931","article-title":"Alterations in PACAP-38-like immunoreactivity in the plasma during ictal and interictal periods of migraine patients","volume":"33","author":"Tuka","year":"2013","journal-title":"Cephalalgia"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"2773","DOI":"10.1097\/j.pain.0000000000000702","article-title":"Premonitory and nonheadache symptoms induced by CGRP and PACAP38 in patients with migraine","volume":"157","author":"Guo","year":"2016","journal-title":"Pain"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1097\/WCO.0000000000000440","article-title":"Calcitonin gene-related peptide in peripheral blood as a biomarker for migraine","volume":"30","author":"Ram\u00f3n","year":"2017","journal-title":"Curr Opin Neurol"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1111\/head.13379","article-title":"History and review of anti-calcitonin gene-related peptide (CGRP) therapies: from translational research to treatment","volume":"58","author":"Tepper","year":"2018","journal-title":"Headache"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"211","DOI":"10.3949\/ccjm.87a.19048","article-title":"CGRP antagonists for decreasing migraine frequency: new options, long overdue","volume":"87","author":"Bucklan","year":"2020","journal-title":"Cleve Clin J Med"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1007\/s40263-021-00834-9","article-title":"Indirect comparison of Topiramate and monoclonal antibodies against CGRP or its receptor for the prophylaxis of episodic migraine: a systematic review with Meta-analysis","volume":"35","author":"Overeem","year":"2021","journal-title":"CNS Drugs"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s10194-023-01594-1","article-title":"The comparative effectiveness of migraine preventive drugs: a systematic review and network meta-analysis","volume":"24","author":"Lampl","year":"2023","journal-title":"J Headache Pain"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s10194-024-01822-2","article-title":"Efficacy and safety of atogepant, a small molecule CGRP receptor antagonist, for the preventive treatment of migraine: a systematic review and meta-analysis","volume":"25","author":"Hou","year":"2024","journal-title":"J Headache Pain"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s11916-025-01365-4","article-title":"Review: An update on CGRP monoclonal antibodies for the preventive treatment of episodic migraine","volume":"29","author":"Nicol","year":"2025","journal-title":"Curr Pain Headache Rep"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"1387044","DOI":"10.3389\/fneur.2024.1387044","article-title":"Safety considerations in the treatment with anti-CGRP(R) monoclonal antibodies in patients with migraine","volume":"15","author":"Van Der Arend","year":"2024","journal-title":"Front Neurol"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"e2542","DOI":"10.1002\/brb3.2542","article-title":"Efficacy and safety of calcitonin gene-related peptide antagonists in migraine treatment: a meta-analysis","volume":"12","author":"Huang","year":"2022","journal-title":"Brain Behav"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"e91347","DOI":"10.7759\/cureus.91347","article-title":"Patient adherence and long-term tolerability of anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies in migraine prevention: a systematic review","volume":"17","author":"Ray","year":"2025","journal-title":"Cureus"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1111\/head.14692","article-title":"Calcitonin gene-related peptide-targeting therapies are a first-line option for the prevention of migraine: an American headache society position statement update","volume":"64","author":"Charles","year":"2024","journal-title":"Headache"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"1431562","DOI":"10.3389\/fphar.2024.1431562","article-title":"Real-world study of adverse events associated with gepant use in migraine treatment based on the VigiAccess and U.S. food and drug administration's adverse event reporting system databases","volume":"15","author":"Liang","year":"2024","journal-title":"Front Pharmacol"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1177\/0333102420970889","article-title":"A phase 2, randomized, double-blind, placebo-controlled trial of AMG 301, a pituitary adenylate cyclase-activating polypeptide PAC1 receptor monoclonal antibody for migraine prevention","volume":"41","author":"Ashina","year":"2021","journal-title":"Cephalalgia"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1056\/NEJMoa2314577","article-title":"A monoclonal antibody to PACAP for migraine prevention","volume":"391","author":"Ashina","year":"2024","journal-title":"N Engl J Med"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s10194-023-01599-w","article-title":"The effect of Lu AG09222 on PACAP38- and VIP-induced vasodilation, heart rate increase, and headache in healthy subjects: an interventional, randomized, double-blind, parallel-group, placebo-controlled study","volume":"24","author":"Rasmussen","year":"2023","journal-title":"J Headache Pain"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s10194-025-01959-8","article-title":"Revisiting substance P in migraine: a methodological approach inspired by anti-CGRP and anti-PACAP success","volume":"26","author":"Pellesi","year":"2025","journal-title":"J Headache Pain"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s10194-019-1017-9","article-title":"Advances in genetics of migraine","volume":"20","author":"Sutherland","year":"2019","journal-title":"J Headache Pain"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1186\/s40001-024-01919-z","article-title":"A comprehensive exploration of astrocytes in migraine: a bibliometric and visual analysis","volume":"29","author":"Wei","year":"2024","journal-title":"Eur J Med Res"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"e1002822","DOI":"10.1371\/journal.pcbi.1002822","article-title":"Chapter 11: genome-wide association studies","volume":"8","author":"Bush","year":"2012","journal-title":"PLoS Comput Biol"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1056\/NEJMra1915327","article-title":"Migraine","volume":"383","author":"Ashina","year":"2020","journal-title":"N Engl J Med"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s13311-017-0602-3","article-title":"Targeted orexin and hypothalamic neuropeptides for migraine","volume":"15","author":"Strother","year":"2018","journal-title":"Neurotherapeutics"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1046\/j.1469-7580.1997.19030367.x","article-title":"The distribution of trigeminovascular afferents in the nonhuman primate brain Macaca nemestrina: a c-fos immunocytochemical study","volume":"190","author":"Goadsby","year":"1997","journal-title":"J Anat"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/(sici)1096-9861(19981012)400:1<>3.0.co;2-b","article-title":"Cells of origin of the trigeminohypothalamic tract in the rat","volume":"400","author":"Malick","year":"1998","journal-title":"J Comp Neurol"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"104943","DOI":"10.1016\/j.ebiom.2023.104943","article-title":"Resistant and refractory migraine: clinical presentation, pathophysiology, and management","volume":"99","author":"Ornello","year":"2024","journal-title":"EBioMedicine"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1111\/j.1526-4610.2012.02209.x","article-title":"Beyond neurovascular: migraine as a dysfunctional neurolimbic pain network","volume":"52","author":"Maizels","year":"2012","journal-title":"Headache"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.jpain.2013.02.010","article-title":"Altered structure and resting-state functional connectivity of the basal ganglia in migraine patients without aura","volume":"14","author":"Yuan","year":"2013","journal-title":"J Pain"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s10194-019-1045-5","article-title":"Structural changes of cerebellum and brainstem in migraine without aura","volume":"20","author":"Qin","year":"2019","journal-title":"J Headache Pain"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1111\/cei.13279","article-title":"Neuroimmunology - the past, present and future","volume":"197","author":"Nutma","year":"2019","journal-title":"Clin Exp Immunol"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"10237","DOI":"10.1073\/pnas.172399499","article-title":"Appraising the brain's energy budget","volume":"99","author":"Raichle","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"803475","DOI":"10.3389\/fimmu.2021.803475","article-title":"The interplay between neuroinfections, the immune system and neurological disorders: a focus on Africa","volume":"12","author":"Ngarka","year":"2022","journal-title":"Front Immunol"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.3390\/brainsci13071005","article-title":"The brain's Glymphatic system: drawing new perspectives in neuroscience","volume":"13","author":"Ciurea","year":"2023","journal-title":"Brain Sci"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.4065\/80.10.1326","article-title":"Neuron-astrocyte interactions: partnership for normal function and disease in the central nervous system","volume":"80","author":"Benarroch","year":"2005","journal-title":"Mayo Clin Proc"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.14336\/AD.2023.0623","article-title":"Astrocyte-microglia crosstalk: a novel target for the treatment of migraine","volume":"15","author":"Sun","year":"2024","journal-title":"Aging Dis"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1177\/0271678X17690537","article-title":"Exploring the role of microglia in cortical spreading depression in neurological disease","volume":"37","author":"Shibata","year":"2017","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1111\/head.13512","article-title":"Recent insights in migraine with Aura: a narrative review of advanced neuroimaging","volume":"59","author":"Russo","year":"2019","journal-title":"Headache"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.ncl.2019.07.008","article-title":"An update: pathophysiology of migraine","volume":"37","author":"Goadsby","year":"2019","journal-title":"Neurol Clin"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s11910-020-01037-3","article-title":"Migraine Aura: updates in pathophysiology and management","volume":"20","author":"Lai","year":"2020","journal-title":"Curr Neurol Neurosci Rep"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1152\/physrev.00027.2014","article-title":"Spreading depression, spreading Depolarizations, and the cerebral vasculature","volume":"95","author":"Ayata","year":"2015","journal-title":"Physiol Rev"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.3390\/ijms252011163","article-title":"Molecular and cellular neurobiology of spreading depolarization\/depression and migraine: a narrative review","volume":"25","author":"Kitamura","year":"2024","journal-title":"Int J Mol Sci"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s10194-010-0282-4","article-title":"Migraine and psychiatric comorbidity: a review of clinical findings","volume":"12","author":"Antonaci","year":"2011","journal-title":"J Headache Pain"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s10194-025-01973-w","article-title":"Migraine and stroke: correlation, coexistence, dependence - a modern perspective","volume":"26","author":"Boro\u0144czyk","year":"2025","journal-title":"J Headache Pain"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1097\/01.wco.0000169750.52406.a2","article-title":"Comorbidity of migraine","volume":"18","author":"Scher","year":"2005","journal-title":"Curr Opin Neurol"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13052-017-0344-1","article-title":"The link between obesity and migraine in childhood: a systematic review","volume":"43","author":"Farello","year":"2017","journal-title":"Ital J Pediatr"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"1342111","DOI":"10.3389\/fneur.2024.1342111","article-title":"Drug-related side effects and adverse reactions in the treatment of migraine: a bibliometric and visual analysis","volume":"15","author":"Wei","year":"2024","journal-title":"Front Neurol"},{"key":"ref112","doi-asserted-by":"publisher","first-page":"c5222","DOI":"10.1136\/bmj.c5222","article-title":"Tricyclic antidepressants and headaches: systematic review and meta-analysis","volume":"341","author":"Jackson","year":"2010","journal-title":"BMJ"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s10194-024-01719-0","article-title":"Migraine - a borderland disease to epilepsy: near it but not of it","volume":"25","author":"Paungarttner","year":"2024","journal-title":"J Headache Pain"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1007\/s00415-020-09726-2","article-title":"Menstrual migraine: what it is and does it matter?","volume":"268","author":"Cupini","year":"2021","journal-title":"J Neurol"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s10194-018-0876-9","article-title":"Exploration of intrinsic brain activity in migraine with and without comorbid depression","volume":"19","author":"Ma","year":"2018","journal-title":"J Headache Pain"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"e0320937","DOI":"10.1371\/journal.pone.0320937","article-title":"Cabergoline as a preventive migraine treatment: a randomized clinical pilot trial","volume":"20","author":"Hjelholt","year":"2025","journal-title":"PLoS One"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1111\/head.14943","article-title":"Swiss quality of life and health care impact assessment in a real-world Erenumab-treated migraine population: results over 2\u202fyears","volume":"65","author":"Gantenbein","year":"2025","journal-title":"Headache"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"e42304","DOI":"10.1097\/MD.0000000000042304","article-title":"Economic impact of acupuncture for the prevention of episodic migraine and chronic migraine in Taiwan","volume":"104","author":"Wu","year":"2025","journal-title":"Medicine"},{"key":"ref119","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s11916-024-01314-7","article-title":"Update on Neuromodulation for migraine and other primary headache disorders: recent advances and new indications","volume":"29","author":"Cocores","year":"2025","journal-title":"Curr Pain Headache Rep"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"164","DOI":"10.3390\/healthcare13020164","article-title":"Framing and Management of Migraines in women: An expert opinion on challenges, current approaches, and future multidisciplinary perspectives","volume":"13","author":"Barbanti","year":"2025","journal-title":"Healthcare (Basel)"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"3331024251329400","DOI":"10.1177\/03331024251329400","article-title":"Migraine and insufficient sleep: the effect of sleep restriction on nociceptive evoked potentials in migraine","volume":"45","author":"Omland","year":"2025","journal-title":"Cephalalgia"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"105335","DOI":"10.1016\/j.jpain.2025.105335","article-title":"Risks and familial coaggregation of suicide, accident mortality, and psychiatric disorders in first-degree relatives of individuals with migraine","volume":"29","author":"Hsu","year":"2025","journal-title":"J Pain"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"1556498","DOI":"10.3389\/fgene.2025.1556498","article-title":"Correlation of tumor necrosis factor-\u03b1 and interleukin-1 single-nucleotide polymorphisms with the risk of migraine development","volume":"16","author":"Huang","year":"2025","journal-title":"Front Genet"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"3331024241306103","DOI":"10.1177\/03331024241306103","article-title":"Exploring the association between familial hemiplegic migraine genes (CACNA1A, ATP1A2 and SCN1A) with migraine and epilepsy: a UK biobank exome-wide association study","volume":"45","author":"Staehr","year":"2025","journal-title":"Cephalalgia"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1080\/01616412.2025.2497480","article-title":"Effect of pain-related sodium channels SCN9A and SCN10A polymorphisms in migraine chronification","volume":"47","author":"Kilic","year":"2025","journal-title":"Neurol Res"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"341","DOI":"10.54029\/2025sni","article-title":"Rare trigeminovascular signs during migraine attack","volume":"30","author":"Taskiran-Sag","year":"2025","journal-title":"Neurol Asia"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s10194-025-02043-x","article-title":"Unmasking the relationship between CGRP and glutamate: from peripheral excitation to central sensitization in migraine","volume":"26","author":"Martami","year":"2025","journal-title":"J Headache Pain"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"104359","DOI":"10.1016\/j.braindev.2025.104359","article-title":"Tryptophan metabolism in children with migraine: the role of kynurenine pathway","volume":"47","author":"\u015eahin","year":"2025","journal-title":"Brain Dev"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s10194-025-01998-1","article-title":"Migraine with and without aura-two distinct entities? A narrative review","volume":"26","author":"Grodzka","year":"2025","journal-title":"J Headache Pain"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s10194-025-01948-x","article-title":"Mechanisms underlying CSD initiation implicated by genetic mouse models of migraine","volume":"26","author":"Pietrobon","year":"2025","journal-title":"J Headache Pain"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"165","DOI":"10.54029\/2025amj","article-title":"Ictal and interictal optical coherence tomography angiography findings in patients with migraine","volume":"30","author":"F\u0131rat","year":"2025","journal-title":"Neurol Asia"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s10194-025-02049-5","article-title":"Unveiling new insights into migraine risk stratification using machine learning models of adjustable risk factors","volume":"26","author":"Liu","year":"2025","journal-title":"J Headache Pain"},{"key":"ref133","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s12880-025-01645-w","article-title":"Cerebral morphometric alterations predict the outcome of migraine diagnosis and subtyping: a radiomics analysis","volume":"25","author":"Wang","year":"2025","journal-title":"BMC Med Imaging"},{"key":"ref134","doi-asserted-by":"publisher","first-page":"e70414","DOI":"10.1002\/brb3.70414","article-title":"Abnormal functional network centrality and causal connectivity in migraine without Aura: a resting-state fMRI study","volume":"15","author":"Zhang","year":"2025","journal-title":"Brain Behav"},{"key":"ref135","doi-asserted-by":"publisher","first-page":"1452614","DOI":"10.3389\/fphar.2024.1452614","article-title":"Multi-omics approaches to deciphering complex pathological mechanisms of migraine: a systematic review","volume":"15","author":"Liu","year":"2024","journal-title":"Front Pharmacol"},{"key":"ref136","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12944-025-02432-w","article-title":"The association between lipid-related obesity indicators and severe headache or migraine: a nationwide cross sectional study from NHANES 1999 to 2004","volume":"24","author":"Sun","year":"2025","journal-title":"Lipids Health Dis"},{"key":"ref137","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s11910-025-01408-8","article-title":"The gut microbiome and migraine: updates in understanding","volume":"25","author":"Zhang","year":"2025","journal-title":"Curr Neurol Neurosci Rep"},{"key":"ref138","doi-asserted-by":"publisher","first-page":"1549251","DOI":"10.3389\/fnut.2025.1549251","article-title":"Association between dietary index for gut microbiota and self-reported severe headache or migraine in U.S. adults: a cross-sectional study from NHANES","volume":"12","author":"Liu","year":"2025","journal-title":"Front Nutr"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1007\/s13760-025-02779-y","article-title":"The association between migraine and gut microbiota: a systematic review","volume":"125","author":"Gorenshtein","year":"2025","journal-title":"Acta Neurol Belg"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1711571\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T05:16:36Z","timestamp":1764566196000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1711571\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,1]]},"references-count":139,"alternative-id":["10.3389\/fneur.2025.1711571"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2025.1711571","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,1]]},"article-number":"1711571"}}