{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:46:11Z","timestamp":1780638371235,"version":"3.54.1"},"reference-count":3,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>\n                    Traumatic brain injury (TBI) research faces persistent challenges in data comparability and reproducibility, particularly in multi-center preclinical studies. Structured, interoperable datasets are essential to identify robust imaging biomarkers and validate cross-site findings. This dataset comprises 343 diffusion-weighted MRI scans from 186 male and female Sprague Dawley rats subjected to controlled cortical impact (CCI) or sham procedures at four independent research sites. Imaging was performed at 3 and 30 days post-injury using harmonized acquisition protocols and field strengths ranging from 7T to 11.7T. A standardized processing pipeline generated scalar diffusion maps (FA, MD, AD, and RD), anatomical templates, and voxel-wise\n                    <jats:italic>z<\/jats:italic>\n                    -score\u2013based indices of injury. Both unharmonized and harmonized versions of the dataset are provided. Harmonization was performed using NeuroCombat for scalar volumes and multi-site template registration for voxel-level alignment. The dataset supports investigations into sex, post-injury timepoint, and injury effects in experimental TBI and provides a foundation for testing image harmonization methods, developing quantification tools for automated assessment of injury, and training machine learning models. The dataset is published in the FAIR\u00b2 framework, with machine-actionable metadata, responsible AI indicators, and structured documentation to support ethical, reproducible, and AI-ready reuse.\n                  <\/jats:p>","DOI":"10.3389\/fneur.2025.1719618","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T05:25:35Z","timestamp":1765776335000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Multi-site, in vivo MRI dataset of brain diffusivity measures before and after harmonization, and atrophy measures following controlled cortical impact in male and female adult rats"],"prefix":"10.3389","volume":"16","author":[{"given":"Gregory","family":"Kislik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru","family":"Korotcov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Febo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Moghadas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Bibic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfan","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieru","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond C.","family":"Koehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temitope","family":"Adebayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"Burns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph T.","family":"McCabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin K. W.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Russell","family":"Huie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam R.","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afshin","family":"Paydar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina B.","family":"Wanner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil G.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The TOP-NT Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.neuroimage.2017.08.047","article-title":"Harmonization of multi-site diffusion tensor imaging data","volume":"161","author":"Fortin","year":"2017","journal-title":"Neuroimage."},{"key":"B2","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1089\/neu.2023.0653","article-title":"Prospective harmonization, common data elements, and sharing strategies for multicenter pre-clinical traumatic brain injury research in the Translational Outcomes Project in Neurotrauma Consortium","volume":"42","author":"Wanner","year":"2025","journal-title":"J Neurotrauma."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.34945\/F5D60C","article-title":"Harmonization of multi-site neuroimaging data from left hemisphere sprague-dawley male and female rat CCI injury: a Translational Outcomes Project in NeuroTrauma (TOP-NT) Consortium Study","author":"Kislik","year":"2025","journal-title":"Open Data Commons for Traumatic Brain Injury"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1719618\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T16:37:23Z","timestamp":1765816643000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1719618\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":3,"alternative-id":["10.3389\/fneur.2025.1719618"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2025.1719618","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,15]]},"article-number":"1719618"}}