{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T05:29:45Z","timestamp":1766122185731,"version":"3.48.0"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sudden sensorineural hearing loss (SSNHL) is a medical emergency that can significantly impact quality of life. The study aimed to compare the efficacy and safety of intratympanic methylprednisolone therapy (IMT) with standard treatment (ST) in adult patients suffering from unilateral SSNHL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on 300 adult patients diagnosed with unilateral SSNHL, treated at our hospital from June 2022 to November 2024. Patients were divided into two groups based on their treatment protocols: IMT group (142 patients) and ST group (158 patients). All patients completed 1\u2009year of follow-up. Outcomes were assessed via pure tone average (PTA), word recognition score (WRS), tinnitus\/dizziness resolution, and quality of life (SF-36).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The IMT group showed significantly greater improvement in PTA and WRS at both follow-up points compared to the ST group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05). Tinnitus reduction was also significantly better in the IMT group at 10\u2009days and 8\u2009weeks (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.01). Overall treatment efficacy (cured + markedly effective + effective) was significantly higher with IMT (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031), especially in severe cases (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034). ST caused more systemic side effects like gastrointestinal issues and blood sugar problems (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05). IMT caused more local ear discomfort (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). Quality of life (SF-36) scores for physical functioning, role-physical, and social functioning were significantly better in the IMT group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05). Logistic regression confirmed IMT significantly reduced the risk of ineffective treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IMT demonstrated superior efficacy and an acceptable safety profile compared to ST for adult patients with unilateral SSNHL, suggesting it as a preferable therapeutic option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2025.1743157","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T05:17:53Z","timestamp":1766121473000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of intratympanic methylprednisolone versus standard therapy in adult sudden sensorineural hearing loss"],"prefix":"10.3389","volume":"16","author":[{"given":"Xiang-Da","family":"Meng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bu-Tian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1179579","DOI":"10.3389\/fneur.2023.1179579","article-title":"Characteristics and prognostic analysis of simultaneous bilateral sudden sensorineural hearing loss","volume":"14","author":"Wang","year":"2023","journal-title":"Front Neurol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"4937","DOI":"10.3390\/jcm13164937","article-title":"Comparison of recovery rates of sudden sensorineural hearing loss by age group","volume":"13","author":"Ha","year":"2024","journal-title":"J Clin Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1142459","DOI":"10.3389\/fneur.2023.1142459","article-title":"Comorbidities and laboratory changes of sudden sensorineural hearing loss: a review","volume":"14","author":"Xie","year":"2023","journal-title":"Front Neurol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"fcae317","DOI":"10.1093\/braincomms\/fcae317","article-title":"The relationship between changes in functional connectivity gradients and cognitive-emotional disorders in sudden sensorineural hearing loss","volume":"6","author":"Li","year":"2024","journal-title":"Brain Commun"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1121324","DOI":"10.3389\/fneur.2023.1121324","article-title":"Diagnosis, differential diagnosis, and treatment for sudden sensorineural hearing loss: current otolaryngology practices in China","volume":"14","author":"Chen","year":"2023","journal-title":"Front Neurol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1202504","DOI":"10.3389\/fmed.2023.1202504","article-title":"Corticosteroids in COVID-19: pros and cons","volume":"10","author":"Bahsoun","year":"2023","journal-title":"Front Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"216","DOI":"10.3122\/jabfm.2021.01.200199","article-title":"Sudden sensorineural hearing loss: a diagnostic and therapeutic emergency","volume":"34","author":"Prince","year":"2021","journal-title":"J Am Board Fam Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.joto.2016.02.002","article-title":"A comparison of effects of systemic and intratympanic steroid therapies for sudden sensorineural hearing loss: a meta-analysis","volume":"11","author":"Zhao","year":"2016","journal-title":"J Otol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1080\/00016489.2023.2244003","article-title":"Intratympanic dexamethasone in mani\u00e8res disease and symptom control","volume":"143","author":"Tomanovic","year":"2023","journal-title":"Acta Otolaryngol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.joto.2021.02.001","article-title":"Intratympanic vs systemic use of steroids as first-line treatment for sudden hearing loss: a meta-analysis of randomized, controlled trials","volume":"16","author":"Yang","year":"2021","journal-title":"J Otol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"114587","DOI":"10.1016\/j.jep.2021.114587","article-title":"Efficacy and safety of standardized Ginkgo biloba L. leaves extract as an adjuvant therapy for sudden sensorineural hearing loss: a systematic review and meta-analysis","volume":"282","author":"Si","year":"2022","journal-title":"J Ethnopharmacol"},{"key":"ref12","first-page":"24","article-title":"A review on central nervous system effects of gastrodin","volume-title":"Front Pharmacol","author":"Liu","year":"2018"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.5336\/medsci.2011-24911","article-title":"Intratympanic methyl prednisolone salvage therapy for sudden hearing loss","volume":"32","author":"Hidir","year":"2012","journal-title":"Turk Klin J Med Sci"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1007\/s00405-009-1130-5","article-title":"Modified intratympanic treatment for idiopathic sudden sensorineural hearing loss","volume":"267","author":"Kara","year":"2010","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1002\/lary.26514","article-title":"Laboratory assessment of sudden sensorineural hearing loss: a case-control study","volume":"127","author":"Fasano","year":"2017","journal-title":"Laryngoscope"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1097\/AUD.0000000000001263","article-title":"Predicting aided outcome with aided word recognition scores measured with linear amplification at above-conversational levels","volume":"44","author":"Fereczkowski","year":"2023","journal-title":"Ear Hear"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1080\/14992027.2021.1881318","article-title":"The world report on hearing - a new era for global hearing care","volume":"60","author":"Clark","year":"2021","journal-title":"Int J Audiol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"3130","DOI":"10.1097\/00007632-200012150-00008","article-title":"SF-36 health survey update","volume":"25","author":"Ware","year":"2000","journal-title":"Spine"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"3321","DOI":"10.12998\/wjcc.v12.i18.3321","article-title":"Therapeutic efficacy of methylprednisolone sodium succinate via diverse administration routes for mid- to high-frequency sudden sensorineural hearing loss","volume":"12","author":"Meng","year":"2024","journal-title":"World J Clin Cases"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"e076872","DOI":"10.1136\/bmjopen-2023-076872","article-title":"The effectiveness of intratympanic injections with methylPREDnisolon versus placebo in the treatment of vertigo attacks in MENi\u00e8re's disease (PREDMEN trial): a study protocol for a phase-3 multicentre, double-blinded, randomised, placebo-controlled trial","volume":"14","author":"Boreel","year":"2024","journal-title":"BMJ Open"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1017\/S0022215109990685","article-title":"Intratympanic methylprednisolone injections for subjective tinnitus","volume":"123","author":"Topak","year":"2009","journal-title":"J Laryngol Otol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"451","DOI":"10.5152\/iao.2018.4871","article-title":"Intratympanic methylprednisolone versus dexamethasone for the primary treatment of idiopathic sudden sensorineural hearing loss","volume":"14","author":"Tarkan","year":"2018","journal-title":"J Int Adv Otol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"816","DOI":"10.24875\/CIRU.22000394","article-title":"Hearing results with combination steroid therapy for sudden sensorineural hearing loss","volume":"91","author":"Garc\u00eda-Rodr\u00edguez","year":"2023","journal-title":"Cir Cir"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"972","DOI":"10.13201\/j.issn.1001-1781.2016.12.012","article-title":"Intratympatic budesonide injection for treatment of refractorysudden sensorineural hearing loss","volume":"30","author":"Sun","year":"2016","journal-title":"Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"91","DOI":"10.21053\/ceo.2021.01459","article-title":"Effectiveness of intratympanic dexamethasone injection for tinnitus treatment: a systematic review and Meta-analysis","volume":"15","author":"Chung","year":"2022","journal-title":"Clin Exp Otorhinolaryngol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1002\/lio2.909","article-title":"Optimal timing of salvage intratympanic steroids in idiopathic sudden sensorineural hearing loss","volume":"7","author":"Wu","year":"2022","journal-title":"Laryngoscope Investig Otolaryngol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1097\/MAO.0000000000003853","article-title":"Clinical factors associated with prognosis of tinnitus and aural fullness after sudden sensorineural hearing loss","volume":"44","author":"Han","year":"2023","journal-title":"Otol Neurotol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"4051","DOI":"10.12998\/wjcc.v8.i18.4051","article-title":"Intratympanic dexamethasone injection for sudden sensorineural hearing loss in pregnancy","volume":"8","author":"Lyu","year":"2020","journal-title":"World J Clin Cases"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e2","DOI":"10.4081\/audiores.2012.e2","article-title":"Intratympanic injection of dexamethasone for treatment of tinnitus in patients with sudden sensorineural hearing loss","volume":"2","author":"Yoshida","year":"2012","journal-title":"Audiol Res"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1080\/00016489.2018.1504170","article-title":"Intratympanic methylprednisolone administration promotes the recovery of idiopathic sudden sensorineural hearing loss: a retrospective case-control study","volume":"138","author":"Jiang","year":"2018","journal-title":"Acta Otolaryngol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"12342","DOI":"10.1038\/s41598-025-97145-6","article-title":"The efficacy of methylprednisolone acetate nanogel in treating patients with sudden sensorineural hearing loss","volume":"15","author":"Amizadeh","year":"2025","journal-title":"Sci Rep"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"186","DOI":"10.5935\/0946-5448.20120033","article-title":"Intratympanic corticotherapy and tinnitus control after sudden hearing loss","volume":"17","author":"Barreto","year":"2012","journal-title":"Int Tinnitus J"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"S217","DOI":"10.1002\/lary.21684","article-title":"Systemic side effects of transtympanic steroids","volume":"120","author":"Robey","year":"2010","journal-title":"Laryngoscope"},{"key":"ref34","first-page":"135","article-title":"Intratympanic versus intravenous corticosteroid treatment for sudden sensorineural hearing loss in diabetic patients: proposed study protocol for a prospective, randomized superiority trial","volume-title":"Trials","author":"Yang","year":"2020"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1002\/lio2.1088","article-title":"Primary versus salvage intratympanic steroid treatment for idiopathic sudden sensorineural hearing loss","volume":"8","author":"Lan","year":"2023","journal-title":"Laryngoscope Investig Otolaryngol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1138354","DOI":"10.3389\/fneur.2023.1138354","article-title":"Efficacy of intratympanic or postauricular subperiosteal corticosteroid injection combined with systemic corticosteroid in the treatment of sudden sensorineural hearing loss: a prospective randomized study","volume":"14","author":"Xie","year":"2023","journal-title":"Front Neurol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"e0332809","DOI":"10.1371\/journal.pone.0332809","article-title":"Intratympanic steroid administration and predictors of recovery in sudden sensorineural hearing loss","volume":"20","author":"Kennedy","year":"2025","journal-title":"PLoS One"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1743157\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T05:17:54Z","timestamp":1766121474000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1743157\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":37,"alternative-id":["10.3389\/fneur.2025.1743157"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2025.1743157","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,19]]},"article-number":"1743157"}}