{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T10:33:21Z","timestamp":1771929201288,"version":"3.50.1"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) is a rare autoimmune disorder affecting the peripheral nerves, typically characterized by muscle weakness and sensory deficits. This study seeks to describe CIDP patients\u2019 journey to diagnosis alongside factors influencing misdiagnosis and time to diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed demographics and diagnostic data reported by neurologists and their patients in Adelphi\u2019s CIDP Disease Specific Programme\u2122. This digital, multinational real-world survey was held in the UK, France, Germany, Italy and Spain between September 2022 and April 2023 (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f542).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean (SD) age was 54.0 (12.4) years; 62% of patients were male. Half of the patients reported at least one comorbidity, with anxiety, depression and diabetes being the most common. The mean (SD) number of diagnostic procedures undergone per patient was 19.6 (9.4). An electromyogram and nerve conduction study (98%), complete blood count (82%) and administration of anti-ganglioside antibodies (78%) were carried out most frequently. Most patients had been diagnosed with typical CIDP (68%) and 37% had been misdiagnosed at least once. The most common misdiagnosis was Guillain-Barr\u00e9 syndrome, in 37% of cases. No significant associations were found between misdiagnosis and the variables sex, disease severity at symptom onset, age category, BMI or CIDP subtype. The median (Q1 - Q3) time between symptom onset and diagnosis was 7.0 (3.2\u201313.0) months. A multiple linear analysis on the log-transform of the time to diagnosis indicated that patients with a long time to diagnosis more often presented with mild symptoms at onset, had variant CIDP and had been misdiagnosed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Median time to diagnosis for CIDP patients was 7\u202fmonths; over a third had at some point been misdiagnosed. Mild symptoms, having variant CIDP and having been misdiagnosed were associated with longer time to diagnosis. Further research into the causes of diagnostic delay and the impact of late diagnosis and treatment is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2025.1748903","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T05:35:02Z","timestamp":1770183302000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The journey to diagnosis for patients with CIDP: results from a real-world international survey"],"prefix":"10.3389","volume":"16","author":[{"given":"Cl\u00e9mence","family":"Arvin-Berod","sequence":"first","affiliation":[{"name":"Argenx","place":["Ghent, Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Febe","family":"Brackx","sequence":"additional","affiliation":[{"name":"Services in Health Economics (SHE) BV","place":["Brussels, Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Van de Veire","sequence":"additional","affiliation":[{"name":"Services in Health Economics (SHE) BV","place":["Brussels, Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Paci","sequence":"additional","affiliation":[{"name":"Argenx","place":["Ghent, Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin","family":"Taylor","sequence":"additional","affiliation":[{"name":"Adelphi Real World","place":["Bollington, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Wright","sequence":"additional","affiliation":[{"name":"Adelphi Real World","place":["Bollington, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra P\u00e9rez","family":"del Real","sequence":"additional","affiliation":[{"name":"Neuropat\u00edas Autoinmunes GBS | CIDP Espa\u00f1a","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Philippe","family":"Plan\u00e7on","sequence":"additional","affiliation":[{"name":"European Patient Organisation for Dysimmune and Inflammatory Neuropathies","place":["Le Pouliguen, France"]},{"name":"Association Fran\u00e7aise Contre les Neuropathies P\u00e9riph\u00e9riques","place":["Paris, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Sperry","sequence":"additional","affiliation":[{"name":"GBS | CIDP Foundation International","place":["Conshohocken, PA, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelsey","family":"Fix","sequence":"additional","affiliation":[{"name":"GBS | CIDP Foundation International","place":["Conshohocken, PA, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Dewilde","sequence":"additional","affiliation":[{"name":"Services in Health Economics (SHE) BV","place":["Brussels, Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuf A.","family":"Rajabally","sequence":"additional","affiliation":[{"name":"Aston Medical School, Aston University","place":["Birmingham, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1575464","DOI":"10.3389\/FIMMU.2025.1575464\/FULL","article-title":"A pathophysiological and mechanistic review of chronic inflammatory demyelinating polyradiculoneuropathy therapy","volume":"16","author":"Caballero-\u00c1vila","year":"2025","journal-title":"Front Immunol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1111\/JNS.12455\/SUPINFO","article-title":"European academy of neurology\/peripheral nerve society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task 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