{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T11:08:21Z","timestamp":1768388901852,"version":"3.49.0"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To report the unusual case of a herpes zoster ophthalmicus (HZO) complicated by central retinal artery occlusion and viral encephalitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>A 65-year-old male with HZO who underwent intravenous acyclovir treatment complained of sudden onset blurry vision of his left eye. Central retinal artery occlusion (CRAO) was revealed. We administered methylprednisolone pulse therapy, yet resulted in no visual acuity improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There were only a few cases reported to have CRAO after diagnosed HZO. This cause of viral-related CRAO led to a complicated treatment decision.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2025.1751103","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T06:47:56Z","timestamp":1768373276000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Initial diagnosis of herpes zoster ophthalmicus complicated by central retinal artery occlusion and subsequent varicella-zoster virus encephalitis: a case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Tsai-Wei","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Show Chwan Memorial Hospital","place":["Changhua, Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Chien","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Show Chwan Memorial Hospital","place":["Changhua, Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.ophtha.2007.10.009","article-title":"Herpes zoster ophthalmicus natural history, risk factors, clinical presentation, and morbidity","volume":"115","author":"Liesegang","year":"2008","journal-title":"Ophthalmology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s13365-023-01144-0","article-title":"Stroke risk after varicella-zoster virus infection: a systematic review and meta-analysis","volume":"29","author":"Lu","year":"2023","journal-title":"J Neurovirol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s13365-013-0183-9","article-title":"Varicella zoster virus vasculopathy: clinical features and pathogenesis","volume":"20","author":"Nagel","year":"2014","journal-title":"J 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