{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:46:26Z","timestamp":1782279986379,"version":"3.54.5"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to investigate the differences between symptomatic and asymptomatic carotid webs (CWs) using clinical and ultrasound morphological features and identify potential risk factors for CW-associated ischemic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively recruited 45 patients diagnosed with CW between January 2021 and September 2024 using digital subtraction angiography or computed tomography angiography. Patients were categorized according to the occurrence of CW-associated stroke. Multimodal ultrasound was used to identify the morphological characteristics of the CWs, carotid stenosis rate and hemodynamic alterations. Binary-variable logistic regression was used to assess the high-risk ultrasound morphologic features of CW-induced ischemic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty-five patients with CWs were identified, of whom 15 had stroke-related symptomatic CWs. Symptomatic patients demonstrated higher hyperlipidemia prevalence, had greater web dimensions (length, 5.80\u202f\u00b1\u202f1.64 vs. 4.41\u202f\u00b1\u202f1.67\u202fmm,\n                      <jats:italic>p<\/jats:italic>\n                      =\u202f0.011; thickness, 1.88\u202f\u00b1\u202f0.43 vs. 1.38\u202f\u00b1\u202f0.39\u202fmm,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.001), and a higher prevalence of curved CW shape (80.0% vs. 43.3%,\n                      <jats:italic>p<\/jats:italic>\n                      =\u202f0.044). CW-induced stenosis was more severe in the symptomatic group than in the asymptomatic group (46.35\u202f\u00b1\u202f9.89% vs. 40.13\u202f\u00b1\u202f11.44%), although the majority of the stenoses were mild (&amp;lt;50%). Hemodynamically, while flow velocities were comparable, symptomatic cases showed significantly lower resistance index (0.59\u202f\u00b1\u202f0.10 vs. 0.65\u202f\u00b1\u202f0.07,\n                      <jats:italic>p<\/jats:italic>\n                      =\u202f0.02). Multivariate analysis identified CW length (OR\u202f=\u202f2.10, 95% CI 1.08\u20134.06;\n                      <jats:italic>p<\/jats:italic>\n                      =\u202f0.028), CW thickness (OR\u202f=\u202f21.80, 95% CI 2.43\u2013196.00;\n                      <jats:italic>p<\/jats:italic>\n                      =\u202f0.006), and lower RI as independently associated factors of symptomatic CWs. ROC analysis yielded optimal cutoffs of &amp;gt;1.65\u202fmm for thickness (AUC\u202f=\u202f0.813), &amp;gt; 5.20\u202fmm for length (AUC\u202f=\u202f0.723), and \u2264 0.691 for RI (AUC\u202f=\u202f0.698).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Symptomatic CWs exhibit distinct morphological and hemodynamic features than asymptomatic CWs. These ultrasound-detectable characteristics may help identify high-risk patients for stroke prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1664894","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:47:38Z","timestamp":1782276458000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multimodal ultrasound-based morphological differences between symptomatic and asymptomatic carotid web"],"prefix":"10.3389","volume":"17","author":[{"given":"Chenyang","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders","place":["Hefei, China"]},{"name":"Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health","place":["Hefei, Anhui, China"]},{"name":"Anhui Provincial Institute of Translational Medicine, Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihao","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders","place":["Hefei, China"]},{"name":"Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health","place":["Hefei, Anhui, China"]},{"name":"Anhui Provincial Institute of Translational Medicine, Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders","place":["Hefei, China"]},{"name":"Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health","place":["Hefei, Anhui, China"]},{"name":"Anhui Provincial Institute of Translational Medicine, Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders","place":["Hefei, China"]},{"name":"Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health","place":["Hefei, Anhui, China"]},{"name":"Anhui Provincial Institute of Translational Medicine, Anhui Medical University","place":["Hefei, China"]},{"name":"The School of Mental Health and Psychological Sciences, Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"S6","DOI":"10.1212\/WNL.0000000000012781","article-title":"Global epidemiology of stroke and access to acute ischemic stroke 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symptomatic carotid web: results from the Caroweb study","volume":"50","author":"Marnat","year":"2023","journal-title":"J Neuroradiol"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2026.1664894\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:47:43Z","timestamp":1782276463000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2026.1664894\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,24]]},"references-count":31,"alternative-id":["10.3389\/fneur.2026.1664894"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2026.1664894","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,24]]},"article-number":"1664894"}}