{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:44:09Z","timestamp":1770227049905,"version":"3.49.0"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Functional outcomes following stroke thrombectomy are commonly measured by the modified Rankin Scale (mRS). Due to hemisphere-specific representation of neuropsychological function, the mRS might underestimate persisting functional deficits, particularly in large right-hemispheric strokes. This study aimed to assess infarct volumes and neuropsychological symptoms in patients with left- and right-sided middle cerebral artery (MCA) infarctions treated with thrombectomy, having a favorable outcome at 3\u202fmonths. We hypothesized that patients with right-sided strokes are affected by larger infarct volumes and suffer from neuropsychological and cognitive impairment despite being classified as functionally recovered on the mRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study cohort consisted of 105 patients with MCA infarctions treated with thrombectomy and a favorable outcome at 3\u202fmonths after stroke according to mRS 0-1. The infarct volumes after thrombectomy were measured using imaging data. Consenting patients received follow-up examinations through telephone interviews and written questionnaires (Stroke Impact Scale-16, Short Form-36). Patients with the largest infarct volumes were additionally assessed with a neuropsychological test battery (Test of Attentional Performance \u2013 Mobility-Version, TAP-M) and the Montreal Cognitive Assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean infarct volume was larger in patients with right-sided (23.3\u202fmL) strokes compared to left-sided (8.5\u202fmL) strokes (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). Loss of working ability was reported by 24.3% of patients with right MCA infarctions and 2.9% of patients with left MCA infarctions (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). Compared to age-dependent standard values, patients with right-sided MCA infarctions showed longer reaction times, impaired divided attention, and subclinical neglect to the left. Additionally, the majority of these patients showed mild cognitive impairment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and conclusion<\/jats:title>\n                    <jats:p>These findings indicate that patients with right MCA infarctions, being categorized as having a \u201cfavorable functional outcome\u201d on the mRS, suffer from relevant neuropsychological deficits, subclinical neglect, and reduced quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1686604","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T05:34:38Z","timestamp":1770183278000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuropsychological deficits in patients with favorable outcomes after middle cerebral artery infarction treated with thrombectomy"],"prefix":"10.3389","volume":"17","author":[{"given":"Hannah","family":"Hild","sequence":"first","affiliation":[{"name":"Department of Neurology, Goethe University","place":["Frankfurt am Main, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Foerch","sequence":"additional","affiliation":[{"name":"Department of Neurology, Goethe University","place":["Frankfurt am Main, Germany"]},{"name":"Department of Neurology, RKH Klinikum Ludwigsburg","place":["Ludwigsburg, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariane","family":"Martinez Oeckel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Goethe University","place":["Frankfurt am Main, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1177\/17474930211065917","article-title":"World stroke organization (WSO): global stroke fact sheet 2022","volume":"17","author":"Feigin","year":"2022","journal-title":"Int J Stroke"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"774247","DOI":"10.3389\/fneur.2021.774247","article-title":"Stroke lateralization in large hemisphere infarctions: characteristics, stroke-related complications, and outcomes","volume":"12","author":"Li","year":"2021","journal-title":"Front Neurol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1056\/NEJMoa1415061","article-title":"Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke","volume":"372","author":"Saver","year":"2015","journal-title":"N Engl J 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