{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T08:42:51Z","timestamp":1771922571462,"version":"3.50.1"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate electroacupuncture (EA)-induced reorganization of voxel-mirrored homotopic connectivity (VMHC) and its association with motor recovery in a rat model of ischemic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-four female Sprague\u2013Dawley rats were randomized into Sham group, stroke model group and EA group. The EA group received 1-week treatment (2\/15\u202fHz sparse-dense wave, 2\u202fmA, 30\u202fmin\/day) at GV20. Neurological deficits were assessed using the modified neurological severity score. And resting-state functional magnetic resonance imaging was acquired pre-post-intervention for VMHC analysis. Group differences and VMHC-behavior correlations were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      EA significantly increased VMHC in subcortical motor regions (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.001, alphasim correction) but decreased VMHC in somatosensory cortex versus untreated stroke. Model group showed progressive VMHC reductions in hippocampus, hypothalamus, and somatosensory cortex. Enhanced internal capsule VMHC correlated with improved Longa scores in EA rats (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u202f=\u202f0.206,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EA promotes motor recovery through frequency-specific bidirectional VMHC modulation. This study elucidates EA\u2019s inter-hemispheric connectivity level therapeutic mechanism for stroke rehabilitation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1688307","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T05:28:14Z","timestamp":1768886894000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Electroacupuncture rewires interhemispheric homotopic connectivity to promote motor recovery after ischemic stroke"],"prefix":"10.3389","volume":"17","author":[{"given":"Baokai","family":"Dou","sequence":"first","affiliation":[{"name":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences","place":["Beijing, China"]},{"name":"Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University","place":["Jinan, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangxin","family":"Xing","sequence":"additional","affiliation":[{"name":"Rehabilitation Center, Qilu Hospital of Shandong University","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zexi","family":"Dou","sequence":"additional","affiliation":[{"name":"School of Special Education and Rehabilitation, Binzhou Medical University","place":["Yantai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lv","family":"Gao","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hairu","family":"Huo","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Meng","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuling","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Sui","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1177\/17474930211065917","article-title":"World stroke 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