{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:25:44Z","timestamp":1791980744863,"version":"4.4.0"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study employs bibliometric analysis to systematically examine global research trends and map the intellectual landscape of \u03b1-synuclein (\u03b1-syn) in Parkinson\u2019s disease (PD) from 2015 to 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>On January 14, 2025, bibliographic data were extracted from the web of science core collection (WOSCC) and PubMed. Using CiteSpace (version 6.2.R4), VOSviewer (version 1.6.20), the Bibliometrix R package (4.4.2), and Microsoft Excel 2024, we analyzed publication trends, geographic and institutional contributions, journal distributions, author distributions, co-cited references, and keyword co-occurrences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 10,390 publications were included, with a steady annual growth (R\n                      <jats:sup>2<\/jats:sup>\n                      \u202f=\u202f0.8741). The United States, China, and Germany were the top contributing countries. Leading institutions included the University of Cambridge and the University of Pennsylvania. Core journals such as\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      and\n                      <jats:italic>International Journal of Molecular Sciences<\/jats:italic>\n                      exhibited significant influence. Keyword clustering highlighted research hotspots, including neurodegeneration, aggregation, oxidative stress, Lewy bodies, and emerging diagnostic technologies like RT-QuIC. Important trends were identified in immune mechanisms, exosome-mediated propagation, gut-brain axis involvement, and cross-disease mechanisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The significance of \u03b1-syn in Parkinson\u2019s disease research is growing. Future efforts should emphasize mechanistic studies, biomarker validation, and targeted therapies to advance personalized medicine in PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1712325","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T05:42:28Z","timestamp":1772602948000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["A bibliometric analysis of alpha-synuclein in Parkinson\u2019s disease from 2015 to 2024"],"prefix":"10.3389","volume":"17","author":[{"given":"Liangman","family":"Xiao","sequence":"first","affiliation":[{"name":"First Clinical Medical College, Guangzhou University of CM","place":["Guangzhou, Guangdong Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumin","family":"Lin","sequence":"additional","affiliation":[{"name":"First Clinical Medical College, Guangzhou University of CM","place":["Guangzhou, Guangdong Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Wu","sequence":"additional","affiliation":[{"name":"First Clinical Medical College, Guangzhou University of CM","place":["Guangzhou, Guangdong Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Guangzhou University of CM","place":["Guangzhou, Guangdong Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danxia","family":"Gu","sequence":"additional","affiliation":[{"name":"First Clinical Medical College, Guangzhou University of CM","place":["Guangzhou, Guangdong Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingqi","family":"Fan","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Guangzhou University of CM","place":["Guangzhou, Guangdong Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixing","family":"Zhuang","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Guangzhou University of CM","place":["Guangzhou, Guangdong Province, China"]},{"name":"Guangdong Clinical Research Academy of CM","place":["Guangzhou, Guangdong Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"360","DOI":"10.3390\/ijms25010360","article-title":"Alpha-synuclein contribution to neuronal and glial damage in Parkinson's disease","volume":"25","author":"Saramowicz","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1001\/jama.2019.22360","article-title":"Diagnosis and treatment of Parkinson disease: a 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