{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:08:37Z","timestamp":1792184917508,"version":"4.4.0"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While the association between obstructive sleep apnea (OSA) and chronic inflammation is well-established, the role of novel hematological indices, such as the systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI), remains unclear. Their specific relationship with OSA has not been fully elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 590 consecutive patients with suspected OSA were enrolled between June 2023 and August 2025. OSA was defined as an apnea-hypopnea index (AHI) of \u22655 events per hour. Spearman\u2019s rank correlation analysis was used to assess the relationships among SII, SIRI, AHI, and the lowest SpO\u2082. Logistic regression analyses were performed to examine the associations of SII and SIRI with OSA. Sensitivity analyses were conducted to evaluate the robustness of the findings. Receiver operating characteristic (ROC) curves were generated to assess the discriminative ability of SII and SIRI in identifying patients with OSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 590 patients included in the study, 413 (70%) were diagnosed with OSA. Spearman rank correlation analysis revealed that both SII (\n                      <jats:italic>r<\/jats:italic>\n                      =\u202f0.541,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.001) and SIRI (\n                      <jats:italic>r<\/jats:italic>\n                      =\u202f0.412,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.001) were positively correlated with AHI. Conversely, SII (\n                      <jats:italic>r<\/jats:italic>\n                      =\u202f\u22120.470,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.001) and SIRI (\n                      <jats:italic>r<\/jats:italic>\n                      =\u202f\u22120.374,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.001) were inversely correlated with the lowest SpO\u2082. Binary logistic regression identified both SII (odds ratio [OR]\u202f=\u202f1.601; 95% CI: 1.352\u20131.987;\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.001) and SIRI (OR\u202f=\u202f1.459; 95% CI: 1.182\u20131.750;\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.001) as independent risk factors for OSA. The area under the curve (AUC) values for predicting OSA were 0.774 for SII, 0.705 for SIRI, and 0.819 for the combination of SII and SIRI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings demonstrate that both the SII and SIRI are independent risk factors for OSA and may serve as potential biomarkers for identifying individuals with OSA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1716598","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:28:35Z","timestamp":1773293315000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Systemic immune-inflammation index and systemic inflammation response index: novel hematological predictors of obstructive sleep apnea"],"prefix":"10.3389","volume":"17","author":[{"given":"Guohua","family":"He","sequence":"first","affiliation":[{"name":"Department of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhu","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second People\u2019s Hospital of Hunan Province (Brain Hospital of Hunan Province)","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangping","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tieqiao","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wengao","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangping","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1001\/jama.2020.3514","article-title":"Diagnosis and management of obstructive sleep apnea: a review","volume":"323","author":"Gottlieb","year":"2020","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1001\/jama.2016.18630","article-title":"Screening for obstructive sleep apnea: implications for the sleep health of the population","volume":"317","author":"Redline","year":"2017","journal-title":"JAMA"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/s1474-4422(21)00321-5","article-title":"Sleep apnoea and ischaemic stroke: current knowledge and future directions","volume":"21","author":"Baillieul","year":"2022","journal-title":"Lancet Neurol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1164\/rccm.201806-1109TR","article-title":"Obstructive sleep apnea, hypoxia, and nonalcoholic fatty liver disease","volume":"199","author":"Mesarwi","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.smrv.2016.07.002","article-title":"Prevalence of obstructive sleep apnea in the general population: a systematic review","volume":"34","author":"Senaratna","year":"2017","journal-title":"Sleep Med 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hemorrhage","volume":"44","author":"Wang","year":"2023","journal-title":"Neurol Sci"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.3390\/jcm12031128","article-title":"Systemic immune inflammation index (SII), system inflammation response index (SIRI) and risk of all-cause mortality and cardiovascular mortality: a 20-year follow-up cohort study of 42,875 US adults","volume":"12","author":"Xia","year":"2023","journal-title":"J Clin Med"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1186\/s12933-025-02721-9","article-title":"Association between systemic inflammation biomarkers and incident cardiovascular disease in 423,701 individuals: evidence from the UK biobank cohort","volume":"24","author":"Qin","year":"2025","journal-title":"Cardiovasc Diabetol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"101838","DOI":"10.1016\/j.smrv.2023.101838","article-title":"Longitudinal risk factors for obstructive sleep apnea: a 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surgery","volume":"145","author":"G\u00fcnd\u00fcz","year":"2025","journal-title":"Acta Otolaryngol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.biopsych.2015.05.014","article-title":"Sleep disturbance, sleep duration, and inflammation: a systematic review and meta-analysis of cohort studies and experimental sleep deprivation","volume":"80","author":"Irwin","year":"2016","journal-title":"Biol Psychiatry"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1080\/07420528.2022.2048663","article-title":"Blunted rest-activity rhythm is associated with increased white blood-cell-based inflammatory markers in adults: an analysis from NHANES 2011-2014","volume":"39","author":"Xu","year":"2022","journal-title":"Chronobiol Int"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1097\/psy.0000000000000363","article-title":"Reciprocal relationship between sleep macrostructure and evening and morning cellular inflammation in rheumatoid arthritis","volume":"79","author":"Bjurstr\u00f6m","year":"2017","journal-title":"Psychosom Med"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.smrv.2017.10.005","article-title":"Tumor necrosis factor alpha in sleep regulation","volume":"40","author":"Rockstrom","year":"2018","journal-title":"Sleep Med Rev"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1186\/s12890-020-01253-0","article-title":"Association between tumor necrosis factor alpha and obstructive sleep apnea in adults: a meta-analysis update","volume":"20","author":"Cao","year":"2020","journal-title":"BMC Pulm Med"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.bbi.2015.01.004","article-title":"Influence of sleep deprivation and circadian misalignment on cortisol, inflammatory markers, and cytokine balance","volume":"47","author":"Wright","year":"2015","journal-title":"Brain Behav Immun"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1210\/jcem.84.8.5894","article-title":"Circadian interleukin-6 secretion and quantity and depth of sleep","volume":"84","author":"Vgontzas","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.bbi.2014.11.017","article-title":"Differential acute effects of sleep on spontaneous and stimulated production of tumor necrosis factor in men","volume":"47","author":"Dimitrov","year":"2015","journal-title":"Brain Behav Immun"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.biopsych.2015.01.010","article-title":"Cognitive behavioral therapy and tai chi reverse cellular and genomic markers of inflammation in late-life insomnia: a randomized controlled trial","volume":"78","author":"Irwin","year":"2015","journal-title":"Biol Psychiatry"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1146\/annurev-psych-010213-115205","article-title":"Why sleep is important for health: a psychoneuroimmunology perspective","volume":"66","author":"Irwin","year":"2015","journal-title":"Annu Rev Psychol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"242","DOI":"10.3181\/00379727-210-43945","article-title":"Influenza viral infections enhance sleep in mice","volume":"210","author":"Fang","year":"1995","journal-title":"Proc Soc Exp Biol Med"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.psyneuen.2012.10.010","article-title":"Sepsis-induced morbidity in mice: effects on body temperature, body weight, cage activity, social behavior and cytokines in 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NSUN6 protects against intermittent hypoxia-induced oxidative stress and inflammatory response in adipose tissue through suppressing macrophage ferroptosis and M1 polarization","volume":"364","author":"Wang","year":"2025","journal-title":"Life Sci"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"47","DOI":"10.2174\/138161211795049804","article-title":"Mikhailidis DP and Kitas GD mean platelet volume: a link between thrombosis and inflammation?","volume":"17","author":"Gasparyan","year":"2011","journal-title":"Curr Pharm Des"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.3390\/bioengineering10121414","article-title":"Vibro-acoustic platelet activation: an additive mechanism of prothrombosis with applicability to snoring and obstructive sleep 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The multi-ethnic study of atherosclerosis","volume":"15","author":"Geovanini","year":"2018","journal-title":"Ann Am Thorac Soc"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.2147\/dddt.S67655","article-title":"Studies of selective TNF inhibitors in the treatment of brain injury from stroke and trauma: a review of the evidence to date","volume":"8","author":"Tuttolomondo","year":"2014","journal-title":"Drug Des Devel Ther"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"2201110","DOI":"10.1183\/13993003.01110-2022","article-title":"Association of obstructive sleep apnoea with cardiovascular events in women and men with acute coronary syndrome","volume":"61","author":"Wang","year":"2023","journal-title":"Eur Respir J"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s12944-020-01358-9","article-title":"Association between triglyceride glucose index and obstructive sleep apnea risk in Korean adults: a cross-sectional cohort study","volume":"19","author":"Kang","year":"2020","journal-title":"Lipids Health Dis"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"e45843","DOI":"10.7759\/cureus.45843","article-title":"Understanding the association between obesity and obstructive sleep apnea syndrome: a case-control study","volume":"15","author":"Patial","year":"2023","journal-title":"Cureus"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41533-023-00351-w","article-title":"Interaction of BMI and respiratory status in obstructive sleep apnea, a cross-sectional COPD study","volume":"33","author":"Hashiguchi","year":"2023","journal-title":"NPJ Prim Care Respir Med"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2026.1716598\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:28:36Z","timestamp":1773293316000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2026.1716598\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,12]]},"references-count":63,"alternative-id":["10.3389\/fneur.2026.1716598"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2026.1716598","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,12]]},"article-number":"1716598"}}