{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T04:54:53Z","timestamp":1781499293434,"version":"3.54.1"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>The patient presenting with memory loss often requires a complex, extensive multidisciplinary specialty evaluation that may begin in the primary care, emergency department, or general neurology setting. The analysis begins with a suspicion or concern regarding cognitive performance raised by the patient, family, or provider. Ideally, a better understanding will empower the primary care and general neurology communities to screen for and appropriately diagnose, treat, or refer patients with dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The thematic focus of this narrative review is diagnosis, imaging, and treatment of Alzheimer\u2019s disease and related dementia (ADRD). Information was abstracted from the National Library of Medicine MEDLINE\/PubMed database. Medical Subject Headings (MeSH) heading search terms included dementia and, more specifically, Alzheimer\u2019s disease. The search targeted primary research, preferentially compared to reviews, consensus statements, or case reports if feasible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Observations<\/jats:title>\n                    <jats:p>Delirium typically represents an acute or subacute fluctuating change in mental status, often temporally related to acute illness. While dementia is typically associated with a more chronic progressive presentation of cognitive change without the presence of concurrent illness. However, subacute or dementia presentations may be exacerbated in that setting as well.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and relevance<\/jats:title>\n                    <jats:p>The diagnosis, management, and therapy of Alzheimer\u2019s disease and related dementia is undergoing rapid change in imaging and now the utility of blood-based biomarkers. As more amyloid-modifying therapy is administered, the acute care systems should be knowledgeable of the treatment course and potential for complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1743770","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T04:26:33Z","timestamp":1781497593000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Alzheimer\u2019s disease and related dementia: evaluation, diagnosis and acute care management"],"prefix":"10.3389","volume":"17","author":[{"given":"Rade B.","family":"Vukmir","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Drexel University","place":["Philadelphia, PA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1055\/s-0035-1555115","article-title":"The impact of age on cognition","volume":"36","author":"Murman","year":"","journal-title":"Semin Hear"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1017\/S1355617710000706","article-title":"Selective review of cognitive aging","volume":"16","author":"Salthouse","year":"2010","journal-title":"J Int Neuropsychol Soc"},{"key":"ref3","first-page":"1","article-title":"Diagnosed dementia in adults age 65 and older: United States, 2022","author":"Kramarow","year":"2024","journal-title":"Natl Health Stat Report"},{"key":"ref4","first-page":"1","volume-title":"A Profile of older Adults with Dementia and their Caregivers Issue Brief","year":"2019"},{"key":"ref5","volume-title":"Review: What\u2019s the difference between Alzheimer\u2019s disease and dementia? 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