{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:10:31Z","timestamp":1793211031039,"version":"4.5.0"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Bilateral vestibulopathy (BVP) is a chronic, disabling disorder characterized by bilateral loss of vestibular function, leading to imbalance, oscillopsia, and falls. Despite established diagnostic criteria, clinical expression and rehabilitation potential vary widely across etiologies. Understanding these functional signatures is crucial for tailoring future neurostimulation strategies. The main objective of this study is to decode the etiological and functional heterogeneity of BVP and define clinical\u2013functional profiles guiding vestibular or cochleo-vestibular implant candidacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multicenter retrospective study included 119 adults fulfilling B\u00e1r\u00e1ny Society criteria for definite BVP (&amp;gt;1\u202fyear). Comprehensive audiovestibular testing comprised pure-tone audiometry (PTA), video head impulse test (vHIT), vestibular evoked myogenic potentials (VEMPs), and dynamic posturography (SOT, LOS). Group comparisons used Kruskal\u2013Wallis and Dunn\u2013Bonferroni tests; oscillopsia predictors were analyzed by binary logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Etiologies included idiopathic (29.41%), M\u00e9ni\u00e8re\u2019s disease (26.89%), iatrogenic (18.49%), post-infectious (14.29%), cerebellar ataxia\/CANVAS (6.72%), and post-traumatic (4.20%). Oscillopsia was reported by 48.74% and falls by 22.69%. Significant inter-etiological differences were found for semicircular canal gains (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.001), with idiopathic and M\u00e9ni\u00e8re phenotypes showing higher vHIT gains and CANVAS\/vestibulotoxic forms the lowest. IAAR-VEMP amplitudes were higher in idiopathic and M\u00e9ni\u00e8re groups than in CANVAS and vestibulotoxic etiologies (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.01). Posturography differed across groups (SOT\n                      <jats:italic>p<\/jats:italic>\n                      =\u202f0.007; LOS\n                      <jats:italic>p<\/jats:italic>\n                      =\u202f0.010), CANVAS showing the poorest stability. Logistic regression identified reduced VOR gain in both the lateral and posterior semicircular canals as significant predictors of oscillopsia (LSC: right OR 0.185,\n                      <jats:italic>p<\/jats:italic>\n                      =\u202f0.036; left OR 0.149,\n                      <jats:italic>p<\/jats:italic>\n                      =\u202f0.035; PSC: right OR 0.167,\n                      <jats:italic>p<\/jats:italic>\n                      =\u202f0.043; left OR 0.182,\n                      <jats:italic>p<\/jats:italic>\n                      =\u202f0.047), together with an increased right PR index (OR 1.045,\n                      <jats:italic>p<\/jats:italic>\n                      =\u202f0.010). Fourteen patients (11.76%) were qualified for cochleo-vestibular and the same amount for vestibular implant candidacy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BVP comprises etiology-specific phenotypes. Oscillopsia is driven mainly by VOR performance and PR index in LSC. Integrating auditory status, canal\u2013otolith function, and compensation quality supports precision selection for vestibular versus cochleo-vestibular implantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1745221","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T05:23:13Z","timestamp":1768540993000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Decoding the bilateral vestibulopathy spectrum: etiology-based phenotypes, clinical profiles and pathways to implant candidacy"],"prefix":"10.3389","volume":"17","author":[{"given":"Joan","family":"Lorente-Piera","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Cl\u00ednica Universidad de Navarra","place":["Pamplona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Manrique-Huarte","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Cl\u00ednica Universidad de Navarra","place":["Pamplona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel Ramos","family":"de Miguel","sequence":"additional","affiliation":[{"name":"Cochlear Technology Centre Belgium","place":["Mechelen, Belgium"]},{"name":"Department of Otorhinolaryngology, Complejo Hospitalario Universitario Insular MaternoInfantil","place":["Las Palmas de Gran Canaria, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Ramos-Mac\u00edas","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Complejo Hospitalario Universitario Insular MaternoInfantil","place":["Las Palmas de Gran Canaria, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana Ben\u00edtez","family":"Robaina","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Complejo Hospitalario Universitario Insular MaternoInfantil","place":["Las Palmas de Gran Canaria, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e1n","family":"Picciafuoco","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Cl\u00ednica Universidad de Navarra","place":["Pamplona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Manrique","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Cl\u00ednica Universidad de Navarra","place":["Pamplona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s","family":"P\u00e9rez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Cl\u00ednica Universidad de Navarra","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3233\/VES170619","article-title":"Bilateral vestibulopathy: diagnostic criteria consensus document of the classification committee of the B\u00e1r\u00e1ny society","volume":"27","author":"Strupp","year":"2017","journal-title":"J Vestib Res"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1001\/jamaoto.2021.3673","article-title":"Falls among people with bilateral vestibulopathy: a review of causes, incidence, injuries, and methods","volume":"148","author":"Herssens","year":"2022","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3389\/fneur.2016.00026","article-title":"Bilateral vestibular hypofunction: insights in etiologies, clinical subtypes, and 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