{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T10:59:04Z","timestamp":1771930744016,"version":"3.50.1"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"\n Objective<\/jats:title>\n The study aimed to explore the prevalence of self-reported lifetime epilepsy symptoms (SLESs) and associated factors among an elderly population in Russia.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The population-based Ural Very Old Study (UVOS) was conducted in Bashkortostan, Russia. Of 1882 eligible inhabitants aged 85\u202f+\u202fyears, 1,526 (81.1%) participated, including 389 (25.5%) men and 1,137 (74.5%) women. The participants underwent a detailed medical examination and interview, during which a history of epileptic attacks was assessed using standardized questions.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the 1,526 participants, 1,523 (99.9%), with a mean age of 88.8\u202f\u00b1\u202f2.9\u202fyears (range: 85.0\u2013103.1\u202fyears), provided information on epilepsy-related questions during the interview. A history of self-reported lifetime epilepsy symptoms was found in 23 individuals (1.5%; 95% confidence interval (CI): 0.90, 2.12), including 4 (17%) men. The mean age of these individuals was 89.2\u202f\u00b1\u202f3.8\u202fyears (85.0\u2013103.1\u202fyears). In a multivariable analysis, a higher prevalence of self-reported lifetime epilepsy symptoms was associated with a higher prevalence of neck pain (OR:3.53;95%CI:1.35,9,22;\n p<\/jats:italic>\n \u202f=\u202f0.01), iron deficiency-related anemia (OR: 5.68; 95%CI: 1.66, 19.5;\n p<\/jats:italic>\n \u202f=\u202f0.006), and unconsciousness (OR: 7.5295%CI: 2.69, 21.0;\n p<\/jats:italic>\n \u202f&lt;\u202f0.001), as well as with a lower prevalence of any alcohol consumption (OR:0.14;95%CI:0.05, 0.44;\n p<\/jats:italic>\n \u202f&lt;\u202f0.001) and a higher erythrocyte sedimentation rate (OR: 1.04; 95%CI: 1.01, 1.08;\n p<\/jats:italic>\n \u202f=\u202f0.01). It was not associated with level of education (\n p<\/jats:italic>\n \u202f=\u202f0.67), sex (\n p<\/jats:italic>\n \u202f=\u202f0.54), region of habitation (\n p<\/jats:italic>\n \u202f=\u202f0.18), Russian versus non-Russian ethnic background (\n p<\/jats:italic>\n \u202f=\u202f0.48), prevalence of diabetes (\n p<\/jats:italic>\n \u202f=\u202f0.93), or stages of arterial hypertension (\n p<\/jats:italic>\n \u202f=\u202f0.85).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Self-reported lifetime epilepsy symptoms, experienced at any period of life and assessed using a questionnaire with standardized questions, were reported by 23 of 1,523 participants (1.5%) in this very old population in Bashkortostan. The prevalence was independent of sex, educational level, ethnic background, rural versus urban region of habitation, diabetes mellitus, and arterial hypertension.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fneur.2026.1751674","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T05:22:05Z","timestamp":1770355325000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and associated factors of self-reported lifetime epilepsy symptoms in an older population in Russia: the Ural Very Old Study"],"prefix":"10.3389","volume":"17","author":[{"given":"Mukharram M.","family":"Bikbov","sequence":"first","affiliation":[{"name":"Ufa Eye Research Institute of Bashkir State Medical University","place":["Ufa, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyulli M.","family":"Kazakbaeva","sequence":"additional","affiliation":[{"name":"Ufa Eye Research Institute of Bashkir State Medical University","place":["Ufa, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellina M.","family":"Iakupova","sequence":"additional","affiliation":[{"name":"Ufa Eye Research Institute of Bashkir State Medical University","place":["Ufa, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leisan I.","family":"Gilemzianova","sequence":"additional","affiliation":[{"name":"Ufa Eye Research Institute of Bashkir State Medical University","place":["Ufa, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasiia V.","family":"Insapova","sequence":"additional","affiliation":[{"name":"Ufa Eye Research Institute of Bashkir State Medical University","place":["Ufa, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana A.","family":"Timerbulatova","sequence":"additional","affiliation":[{"name":"Ufa Eye Research Institute of Bashkir State Medical University","place":["Ufa, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songhomitra","family":"Panda-Jonas","sequence":"additional","affiliation":[{"name":"Privatpraxis Prof. Jonas und Dr. Panda-Jonas","place":["Heidelberg, Germany"]},{"name":"Department of Ophthalmology, University Hospital Heidelberg","place":["Heidelberg, Germany"]},{"name":"Rothschild Foundation Hospital, Institut Fran\u00e7ais de Myopie","place":["Paris, France"]},{"name":"LV Prasad Eye Institute","place":["Hyderabad, Telangana, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jost B.","family":"Jonas","sequence":"additional","affiliation":[{"name":"Rothschild Foundation Hospital, Institut Fran\u00e7ais de Myopie","place":["Paris, France"]},{"name":"LV Prasad Eye Institute","place":["Hyderabad, Telangana, India"]},{"name":"Singapore Eye Research Institute, Singapore National Eye Center","place":["Singapore, Singapore"]},{"name":"Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University","place":["Beijing, China"]},{"name":"Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong","place":["Hong Kong SAR,China"]},{"name":"New York Eye and Ear Infirmary of Mount Sinai, Icahn School of Medicine at Mount Sinai","place":["New York, NY, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S0140-6736(18)32596-0","article-title":"Epilepsy in adults","volume":"393","author":"Thijs","year":"2019","journal-title":"Lancet"},{"key":"ref2","volume-title":"Epilepsy: A public health imperative","year":"2019"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e203","DOI":"10.1016\/S2468-2667(24)00302-5","article-title":"Global, regional, and national burden of epilepsy, 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