{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:00:22Z","timestamp":1785214822351,"version":"3.55.0"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>Cerebral fat embolism (CFE) is a rare neurological feature of fat embolism syndrome (FES), often occurring after long bone fractures. It has a mortality rate of approximately 10% and presents with a spectrum of symptoms, ranging from mild confusion to sudden unresponsiveness and death. Diagnosis primarily relies on clinical history and findings, especially when magnetic resonance imaging is unavailable. We report three unique cases involving traumatic long bone fractures in which patients showed varying severity of CFE, including rapid loss of consciousness. These cases highlight the diverse presentations and outcomes of CFE, including associated symptoms, imaging features, treatment approaches, and prognosis.<\/jats:p>","DOI":"10.3389\/fneur.2026.1752690","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:26:50Z","timestamp":1785212810000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The spectrum of neurological derangement due to fat embolism: a case series"],"prefix":"10.3389","volume":"17","author":[{"given":"Fatma","family":"Shalabi","sequence":"first","affiliation":[{"name":"Department of Neurology, Hadassah-Hebrew University Medical Center","place":["Jerusalem, Israel"]},{"name":"Department of General Intensive Care, Hadassah-Hebrew University Medical Center","place":["Jerusalem, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor","family":"Dirini","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care, and Pain Medicine, Hadassah-Hebrew University Medical Center","place":["Jerusalem, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Assayuri","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Hadassah-Hebrew University Medical Center","place":["Jerusalem, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Gomori","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Hadassah-Hebrew University Medical Center","place":["Jerusalem, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Vernon","family":"van Heerden","sequence":"additional","affiliation":[{"name":"Department of General Intensive Care, Hadassah-Hebrew University Medical Center","place":["Jerusalem, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.ijcard.2021.10.151","article-title":"Single-case metanalysis of fat embolism syndrome","volume":"345","author":"He","year":"2021","journal-title":"Int J Cardiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1097\/TA.0000000000004434","article-title":"Fat embolism syndrome after trauma: what you need to know","volume":"97","author":"Kwon","year":"2024","journal-title":"J Trauma Acute Care Surg"},{"key":"ref3","first-page":"334","article-title":"Fat embolism syndrome","volume":"40","author":"Richards","year":"1997","journal-title":"Can J Surg"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s11910-019-0928-9","article-title":"Neurologic complications of fat embolism syndrome","volume":"19","author":"Morales-Vidal","year":"2019","journal-title":"Curr Neurol Neurosci Rep"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"64","DOI":"10.4103\/2229-5151.109426","article-title":"Fat embolism syndrome","volume":"3","author":"Kwiatt","year":"2013","journal-title":"Int J Crit Illn Inj Sci"},{"key":"ref6","volume-title":"Fat Embolism","author":"Adeyinka","year":"2022"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e251-3","DOI":"10.1161\/STROKEAHA.115.011440","article-title":"Cerebral fat embolism: a case of rapid-onset coma","volume":"46","author":"Mijalski","year":"2015","journal-title":"Stroke"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1302\/0301-620X.56B3.408","article-title":"The fat embolism syndrome","author":"Gurd","year":"1974","journal-title":"J Bone Joint Surg Br"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"438","DOI":"10.7326\/0003-4819-99-4-438","article-title":"Fat embolism prophylaxis with corticosteroids. 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