{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:02:52Z","timestamp":1792522972472,"version":"4.5.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Endovascular thrombectomy (EVT) improves outcomes and reduces mortality in acute ischemic stroke. However, despite achieving successful recanalization in most patients, a subset still experiences poor functional outcomes at 3\u202fmonths. This failure, despite complete vessel reopening, is termed futile recanalization (FR). We investigated clinical and radiological predictors of FR in a multicenter cohort in T\u00fcrkiye.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 497 consecutive patients with middle cerebral artery (M1 or M2) occlusion who underwent EVT and achieved modified Thrombolysis in Cerebral Infarction (mTICI) 3 recanalization within 6\u202fh of symptom onset at 19 stroke centers. FR was defined as a modified Rankin Scale (mRS) score \u22654 at 3\u202fmonths. Clinical and radiological parameters were recorded, and logistic regression was used to identify independent predictors of FR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 497 patients, 133 (26.7%) experienced FR despite complete recanalization. Independent predictors included older age (adjusted odds ratio [aOR] 1.07; 95% CI 1.03\u20131.10;\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.001), longer puncture-to-recanalization time (aOR 1.03; 95% CI 1.02\u20131.05;\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.001), higher admission C-reactive protein (aOR 1.01; 95% CI 1.00\u20131.02;\n                      <jats:italic>p<\/jats:italic>\n                      =\u202f0.03), intracranial hemorrhage on 24-h CT (aOR 0.46; 95% CI 0.23\u20130.95;\n                      <jats:italic>p<\/jats:italic>\n                      =\u202f0.04), lower collateral score (aOR 42.98; 95% CI 6.15\u201330.62;\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.001), and higher 24-h NIHSS score (aOR 1.34; 95% CI 1.24\u20131.44;\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Even with early and complete recanalization, elderly patients and those with poor collateral circulation remain at risk for futile recanalization. Identifying these predictors can guide patient selection, procedural planning, and post-procedural management to optimize functional outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1754255","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:22:51Z","timestamp":1773033771000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Predictors of futile recanalization in completely recanalized middle cerebral artery occlusions: multicenter study"],"prefix":"10.3389","volume":"17","author":[{"given":"Z\u00fclfikar","family":"Memi\u015f","sequence":"first","affiliation":[{"name":"Prof. Dr. Cemil Tascioglu City Hospital, Department of Neurology","place":["Istanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdem","family":"G\u00fcrka\u015f","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Health Sciences, Kartal Dr. L\u00fctfi K\u0131rdar City Hospital","place":["Istanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atilla \u00d6zcan","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Eskisehir Osmangazi University","place":["Eski\u015fehir, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilgehan At\u0131lgan","family":"Acar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Sakarya University","place":["Sakarya, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed Nur","family":"\u00d6g\u00fcn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Bolu Abant Izzet Baysal University","place":["Bolu, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emrah","family":"Ayta\u00e7","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, F\u0131rat University","place":["El\u00e2z\u0131\u011f, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c7etin K\u00fcr\u015fad","family":"Akp\u0131nar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Samsun University","place":["Canik, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fenur","family":"\u00d6nalan","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Health Sciences, Kartal Dr. L\u00fctfi K\u0131rdar City Hospital","place":["Istanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E\u015fref","family":"Ak\u0131l","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Dicle University","place":["Diyarbak\u0131r, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"\u00c7abalar","sequence":"additional","affiliation":[{"name":"Department of Neurology, \u0130stanbul Ba\u015fak\u015fehir \u00c7am Sakura City Hospital","place":["Istanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u00e7a","family":"\u00d6zkul","sequence":"additional","affiliation":[{"name":"Department of Neurology, \u0130stanbul Ba\u015fak\u015fehir \u00c7am Sakura City Hospital","place":["Istanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00dcmit","family":"G\u00f6rg\u00fcl\u00fc","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ankara Bilkent City Hospital","place":["Ankara, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Bay\u0131nd\u0131r","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ankara Bilkent City Hospital","place":["Ankara, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaur","family":"Mehdiyev","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ankara Etlik City Hospital","place":["Ankara, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eennur","family":"Deliba\u015f Kat\u0131","sequence":"additional","affiliation":[{"name":"Department of Neurology, Antalya Training and Research Hospital","place":["Antalya, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Recep","family":"Baydemir","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Erciyes University","place":["Kayseri, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Yabalak","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, D\u00fczce University","place":["D\u00fczce, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"Ayka\u00e7","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Eskisehir Osmangazi University","place":["Eski\u015fehir, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehra","family":"Uysal Kocaba\u015f","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Eskisehir Osmangazi University","place":["Eski\u015fehir, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serhan","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kocaeli City Hospital","place":["Izmit, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Do\u011fan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Samsun University","place":["Canik, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Semih","family":"Ar\u0131","sequence":"additional","affiliation":[{"name":"Department of Neurology, \u0130stanbul Ba\u015fak\u015fehir \u00c7am Sakura City Hospital","place":["Istanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"\u00c7etiner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Kutahya Health Sciences University","place":["K\u00fctahya, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferhat","family":"Balgetir","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, F\u0131rat University","place":["El\u00e2z\u0131\u011f, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fettah","family":"Eren","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Sel\u00e7uk University","place":["Konya, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper","family":"Eren","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Atat\u00fcrk University","place":["Erzurum, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naz\u0131m","family":"K\u0131z\u0131lda\u011f","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Atat\u00fcrk University","place":["Erzurum, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utku","family":"\u00c7enikli","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University","place":["Mente\u015fe, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysel B\u00fc\u015fra","family":"\u015ei\u015fman Bayar","sequence":"additional","affiliation":[{"name":"Deparment of Neurology, Yalova Training and Research Hospital","place":["Yalova, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru","family":"Temel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Haseki Training and Research Hospital, University of Health Sciences","place":["Istanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil Alper","family":"Ery\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sakarya Training and Research Hospital","place":["Sakarya, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semanur","family":"Aksu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sakarya Training and Research Hospital","place":["Sakarya, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine","family":"Sayg\u0131n Uysal","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Kutahya Health Sciences University","place":["K\u00fctahya, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"G\u00fcltekin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Dicle University","place":["Diyarbak\u0131r, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cebrail","family":"Durmaz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Dicle University","place":["Diyarbak\u0131r, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammet Duran","family":"Bayar","sequence":"additional","affiliation":[{"name":"Deparment of Neurology, Yalova Training and Research Hospital","place":["Yalova, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onur","family":"Akan","sequence":"additional","affiliation":[{"name":"Prof. Dr. Cemil Tascioglu City Hospital, Department of Neurology","place":["Istanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sena","family":"Boncuk Ula\u015f","sequence":"additional","affiliation":[{"name":"Independent Researcher (MD, Neurologist)","place":["Sakarya, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talip","family":"Asil","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Biruni University","place":["Istanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/S1474-4422(21)00252-0","article-title":"Global, regional, and national burden of stroke and its risk factors, 1990\u20132019: a systematic analysis for the global burden of disease study 2019","volume":"20","year":"2021","journal-title":"Lancet Neurol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1016\/S0140-6736(16)00163-X","article-title":"Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials","volume":"387","author":"Goyal","year":"2016","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e000257","DOI":"10.1161\/SVIN.121.000257","article-title":"Risk factors of futile recanalization following endovascular treatment in patients with large-vessel occlusion: systematic review and Meta-analysis","volume":"2","author":"Shahid","year":"2022","journal-title":"Stroke Vasc Interv Neurol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"3939","DOI":"10.1007\/s10072-023-06879-6","article-title":"No-reflow phenomenon in acute ischemic stroke: an angiographic evaluation","volume":"44","author":"Nicolini","year":"2023","journal-title":"Neurol Sci"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"3594","DOI":"10.1161\/strokeaha.122.039476","article-title":"Reperfusion without functional independence in late presentation of stroke with large vessel occlusion","volume":"53","author":"Seker","year":"2022","journal-title":"Stroke"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1007\/s00062-022-01166-x","article-title":"Full reperfusion without functional independence after mechanical thrombectomy in the anterior circulation: performance of prediction models before versus after treatment initiation","volume":"32","author":"Weyland","year":"2022","journal-title":"Clin Neuroradiol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e1009","DOI":"10.1212\/WNL.0000000000200815","article-title":"Multivariable prediction model for futile recanalization therapies in patients with acute ischemic stroke","volume":"99","author":"Meinel","year":"2022","journal-title":"Neurology"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1159\/000528922","article-title":"Advances in futile reperfusion following endovascular treatment in acute ischemic stroke due to large vessel occlusion","volume":"86","author":"Wang","year":"2023","journal-title":"Eur Neurol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s00234-018-2016-2","article-title":"Rates and predictors of futile recanalization in patients undergoing endovascular treatment in a multicenter clinical trial","volume":"60","author":"Hussein","year":"2018","journal-title":"Neuroradiology"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3174\/ajnr.A4968","article-title":"Impact of modified TICI 3 versus modified TICI 2b reperfusion score to predict good outcome following endovascular therapy","volume":"38","author":"Dargazanli","year":"2017","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1007\/s00330-017-4928-3","article-title":"Improving mTICI2b reperfusion to mTICI2c\/3 reperfusions: a retrospective observational study assessing technical feasibility, safety and clinical efficacy","volume":"28","author":"Kaesmacher","year":"2018","journal-title":"Eur Radiol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1161\/01.str.0000027437.22450.bd","article-title":"Improving the assessment of outcomes in stroke: use of a structured interview to assign grades on the modified Rankin scale","volume":"33","author":"Wilson","year":"2002","journal-title":"Stroke"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"95","DOI":"10.5853\/jos.2023.02292","article-title":"Thrombectomy in stroke patients with low Alberta stroke program early computed tomography score: is modified thrombolysis in cerebral infarction (mTICI) 2c\/3 superior to mTICI 2b?","volume":"26","author":"Elawady","year":"2024","journal-title":"J Stroke"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1136\/svn-2021-001091","article-title":"Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients","volume":"7","author":"Rajashekar","year":"2022","journal-title":"Stroke Vasc Neurol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1136\/jnnp-2023-332118","article-title":"Selecting stroke patients for thrombectomy: is CTA+ASPECTS enough?","volume":"94","author":"Powers","year":"2023","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"39471074","DOI":"10.1227\/neu.0000000000003220","article-title":"Predicting futile recanalization after endovascular thrombectomy for patients with stroke with large cores: the SNAP score","volume":"96","author":"Matsukawa","year":"2024","journal-title":"Neurosurgery"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1186\/s12880-024-01365-7","article-title":"Non-contrast CT radiomics-clinical machine learning model for futile recanalization after endovascular treatment in anterior circulation acute ischemic stroke","volume":"24","author":"Sun","year":"2024","journal-title":"BMC Med Imaging"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1161\/STROKEAHA.124.048994","article-title":"Recanalization does not always equate to reperfusion: no-reflow phenomenon after successful Thrombectomy","volume":"56","author":"Horie","year":"2025","journal-title":"Stroke"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1186\/s12883-024-03912-9","article-title":"Futile recanalization after endovascular treatment in acute ischemic stroke with large ischemic core","volume":"24","author":"Kim","year":"2024","journal-title":"BMC Neurol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1177\/17474930241264737","article-title":"Predictors of futile recanalization in ischemic stroke patients with low baseline NIHSS","volume":"19","author":"Heitkamp","year":"2024","journal-title":"Int J Stroke"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.2147\/NDT.S434225","article-title":"Lymphocyte to monocyte ratio is independently associated with futile recanalization in acute ischemic stroke after endovascular therapy","volume":"19","author":"Guan","year":"2023","journal-title":"Neuropsychiatr Dis Treat"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1159\/000497315","article-title":"Endovascular thrombectomy in the elderly: do radiological and clinical outcomes differ from those in younger patients? A prospective single-center experience","volume":"47","author":"Rezai","year":"2019","journal-title":"Cerebrovasc Dis"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1007\/s00270-014-0920-3","article-title":"Recanalization and mortality rates of thrombectomy with stent-retrievers in octogenarian patients with acute ischemic stroke","volume":"38","author":"Parrilla","year":"2015","journal-title":"Cardiovasc Intervent Radiol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1161\/strokeaha.119.028511","article-title":"Brain atrophy and the risk of futile endovascular reperfusion in acute ischemic stroke","volume":"51","author":"Pedraza","year":"2020","journal-title":"Stroke"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"639","DOI":"10.3174\/ajnr.A6478","article-title":"White matter disease and outcomes of mechanical thrombectomy for acute ischemic stroke","volume":"41","author":"Mistry","year":"2020","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1167549","DOI":"10.3389\/fneur.2023.1167549","article-title":"Inflammation in stroke: initial CRP levels can predict poor outcomes in Endovascularly treated stroke patients","volume":"14","author":"Finck","year":"2023","journal-title":"Front Neurol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/s41582-019-0221-1","article-title":"Thrombo-inflammation in acute Ischaemic stroke\u2014implications for treatment","volume":"15","author":"Stoll","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1034472","DOI":"10.3389\/fnins.2022.1034472","article-title":"Developing and predicting of early mortality after endovascular thrombectomy in patients with acute ischemic stroke","volume":"16","author":"Chen","year":"2022","journal-title":"Front Neurosci"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1279366","DOI":"10.3389\/fnins.2023.1279366","article-title":"Predictors of futile recanalization after endovascular treatment in acute ischemic stroke: a multi-center study","volume":"17","author":"Sun","year":"2023","journal-title":"Front Neurosci"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"89","DOI":"10.54029\/2023kep","article-title":"The CHA2DS2-VASc risk score predicts futile recanalization after endovascular treatment in patients with acute ischemic stroke","volume":"28","author":"Vatan","year":"2023","journal-title":"Neurol Asia"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.3390\/life13101965","article-title":"Comprehensive Meta-analysis of futile recanalization in acute ischemic stroke patients undergoing endovascular Thrombectomy: prevalence, factors, and clinical outcomes","volume":"13","author":"Shen","year":"2023","journal-title":"Life (Basel)"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1136\/neurintsurg-2021-017963","article-title":"Predictors of futile recanalization after endovascular treatment in acute ischemic stroke: a meta-analysis","volume":"14","author":"Deng","year":"2022","journal-title":"J Neurointerv Surg"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1001\/jama.2016.13647","article-title":"Time to treatment with endovascular thrombectomy and outcomes from ischemic stroke: a meta-analysis","volume":"316","author":"Saver","year":"2016","journal-title":"JAMA"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1001\/jama.2019.8286","article-title":"Association between time to treatment with endovascular reperfusion therapy and outcomes in patients with acute ischemic stroke treated in clinical practice","volume":"322","author":"Jahan","year":"2019","journal-title":"JAMA"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1136\/neurintsurg-2015-011758","article-title":"Early arrival at the emergency department is associated with better collaterals, smaller established infarcts and better clinical outcomes with endovascular stroke therapy: SWIFT study","volume":"8","author":"Liebeskind","year":"2016","journal-title":"J Neurointerv Surg."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1161\/STROKEAHA.113.004072","article-title":"Collaterals at angiography and outcomes in the interventional Management of Stroke (IMS) III trial","volume":"45","author":"Liebeskind","year":"2014","journal-title":"Stroke"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"A167","DOI":"10.1161\/str.44.suppl_1.A167","article-title":"Collateral flow and ASPECTS of infarct evolution dominate time to reperfusion in outcomes of TREVO2","volume":"44","author":"Liebeskind","year":"2013","journal-title":"Stroke"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1056\/NEJMoa1212793","article-title":"A trial of imaging selection and endovascular treatment for ischemic stroke","volume":"368","author":"Kidwell","year":"2013","journal-title":"N Engl J Med"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1161\/STROKEAHA.121.034471","article-title":"Collateral circulation in thrombectomy for stroke after 6 to 24 hours in the DAWN trial","volume":"53","author":"Liebeskind","year":"2022","journal-title":"Stroke"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/s12883-024-03719-8","article-title":"Predictors of futile recanalization after endovascular treatment of acute ischemic stroke","volume":"24","author":"Wang","year":"2024","journal-title":"BMC Neurol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1161\/strokeaha.118.022031","article-title":"Operator versus Core lab adjudication of reperfusion after endovascular treatment of acute ischemic stroke","volume":"49","author":"Zhang","year":"2018","journal-title":"Stroke"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2026.1754255\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:22:52Z","timestamp":1773033772000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2026.1754255\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,9]]},"references-count":41,"alternative-id":["10.3389\/fneur.2026.1754255"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2026.1754255","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,9]]},"article-number":"1754255"}}