{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:43:13Z","timestamp":1792190593397,"version":"4.4.0"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Immune dysfunction in rheumatoid arthritis (RA) is a contributing factor to the development of peripheral neuropathy (PN). The objective of our study was to investigate the biological and clinical factors associated with PN in patients with RA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retro-prospective cross-sectional study. A total of 63 patients with RA were included. They were divided into two groups, 18 with PN and 45 without PN. Participants with PN were those with a pathological electroneuromyogram (ENMG) with or without signs and symptoms of PN. Blood samples were taken for the measurement of rheumatoid factor (RF) and C-reactive protein (CRP). The concentration of anti-citrullinated peptide antibodies (ACPA) were collected from patient records. The significance threshold was set at a\n                      <jats:italic>p<\/jats:italic>\n                      -value &amp;lt;0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The majority of participants, 82.5% were female. The mean age was 51.86\u202f\u00b1\u202f13.07\u202fyears. PN was present in 28.6% of the participants. RF and ACPA were positive in 71.4 and 77.8% of the participants, respectively. Severely active RA was significantly associated with the presence of PN (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001, OR\u202f=\u202f55.13). RF concentrations were significantly higher in patients with PN. The area under the ROC curve for RF concentration in predicting PN in patients with RA was 0.7 (AUC\u202f=\u202f0.7), patients with an RF\u202f&amp;gt;\u202f169.10\u202fIU\/mL had a significant risk of presenting PN (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.003, OR\u202f=\u202f8.20).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Severe rheumatoid arthritis is associated with PN. Inflammatory markers may play a key role in the pathogenesis and may provide valuable guidance for the early diagnosis of PN in RA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1755880","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T04:23:01Z","timestamp":1776745381000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical and biological factors associated with the presence of peripheral neuropathy in patients with rheumatoid arthritis"],"prefix":"10.3389","volume":"17","author":[{"given":"Yannick Fogoum","family":"Fogang","sequence":"first","affiliation":[{"name":"Department of Neurology, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang","place":["Dschang, Cameroon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bleriol Fondjo","family":"Azemkeu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang","place":["Dschang, Cameroon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine Sen Henriette","family":"Ngomtcho","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang","place":["Dschang, Cameroon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Kemta","family":"Lekpa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang","place":["Dschang, Cameroon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Noubom","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang","place":["Dschang, Cameroon"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1136\/ard.2010.138461","article-title":"Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European league against rheumatism collaborative initiative","volume":"69","author":"Aletaha","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1056\/nejm200103223441207","article-title":"Cytokine pathways and joint inflammation in rheumatoid arthritis","volume":"344","author":"Choy","year":"2001","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.actpha.2021.12.025","article-title":"La polyarthrite rhumato\u00efde","volume":"61","author":"Malbos","year":"2022","journal-title":"Actual 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