{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:02:32Z","timestamp":1792796552247,"version":"4.5.0"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The majority of research on the patient experience of Parkinson\u2019s disease (PD) has focused on the frequency and burden of late-stage symptoms, with less emphasis on understanding symptoms in the earlier phases of the condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This descriptive, cross-sectional study aimed to identify the most common, burdensome, and worrisome symptoms of early-stage PD (ePD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An online, self-administered survey was completed by people with ePD (within 5\u202fyears of diagnosis) living in the United States and Germany. Descriptive statistics were used to report respondents\u2019 characteristics and responses to the survey questions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of a total of 150 survey participants, 106 were diagnosed with ePD for 0\u20133\u202fyears, while 44 participants were diagnosed for 4\u20135\u202fyears. All respondents reported experiencing tremor, which, together with mobility issues and pain, were most frequently reported as the most burdensome symptoms in both groups. Bradykinesia, mobility issues, memory loss\/time lapse, cognitive impairment, and urinary and gastrointestinal problems were reported with a frequency of at least 30% higher in the 4\u20135-year group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the surveyed population, the reported frequency of symptoms such as tremor, mobility issues, and pain was higher among those who were 4\u20135\u202fyears post-diagnosis, and these symptoms were reported as the most burdensome. The frequency and impact of motor and non-motor symptoms should be evaluated in future interventional clinical trials involving people living with ePD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1756255","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:42:39Z","timestamp":1783485759000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Most common, burdensome, and worrisome symptoms experienced by people living with early Parkinson\u2019s disease in Germany and the United States\u2014Results from a cross-sectional survey"],"prefix":"10.3389","volume":"17","author":[{"given":"Simon","family":"Messner","sequence":"first","affiliation":[{"name":"Novartis Pharma AG","place":["Basel, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c0ngels","family":"Costa","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG","place":["Basel, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Carmody","sequence":"additional","affiliation":[{"name":"Gemic","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekah","family":"Park","sequence":"additional","affiliation":[{"name":"Gemic","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byron","family":"Jones","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG","place":["Basel, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Lucassen","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG","place":["Basel, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Hursey","sequence":"additional","affiliation":[{"name":"Parkinson\u2019s Europe","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"ref1","year":"2024"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1001\/jama.2019.22360","article-title":"Diagnosis and treatment of Parkinson disease: a review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"ref3","first-page":"S168","article-title":"The economic and quality of life burden associated with Parkinson's disease: a focus on symptoms","volume":"18","author":"Boland","year":"2012","journal-title":"Am J Manag Care"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e2327485","DOI":"10.1001\/jamanetworkopen.2023.27485","article-title":"Association of Caregiver Depression Risk with patient outcomes in Parkinson disease","volume":"6","author":"Rashi","year":"2023","journal-title":"JAMA Netw Open"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e2194","DOI":"10.1212\/WNL.0000000000200113","article-title":"Association of motor and nonmotor symptoms with health-related quality of life in a large online cohort of people with Parkinson disease","volume":"98","author":"Bock","year":"2022","journal-title":"Neurology"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.3390\/jcm10091824","article-title":"Evolution of quality of life in persons with Parkinson's disease: a prospective cohort study","volume":"10","author":"Candel-Parra","year":"2021","journal-title":"J Clin Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1212\/WNL.0b013e3181f61311","article-title":"What predicts mortality in Parkinson disease?: a prospective population-based long-term study","volume":"75","author":"Forsaa","year":"2010","journal-title":"Neurology"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/613592","article-title":"The experience of Parkinson's disease: a systematic review and meta-ethnography","volume":"2014","author":"Soundy","year":"2014","journal-title":"Sci World J"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"6949","DOI":"10.1080\/09638288.2021.1981467","article-title":"Adjusting to living with Parkinson's disease; 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