{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T08:12:54Z","timestamp":1773389574603,"version":"3.50.1"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3606104"],"award-info":[{"award-number":["2023YFC3606104"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study employed a network meta-analysis to compare the efficacy of different Traditional Chinese Medicine mind-body exercises and determine their relative efficacy rankings in stroke rehabilitation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive search of nine databases was conducted, covering studies from inception to February 2025. Participants included stroke patients (age \u226518\u202fyears). Interventions evaluated were four Traditional Chinese movement therapies: Tai Ji, Ba Duan Jin, Yi Jin Jing, and Wu Qin Xi. Primary outcomes included objective measures of upper limb function, lower limb function, balance function, and activities of daily living.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 46 randomized controlled trials involving 3,096 stroke patients were included. Network meta-analysis revealed: (1) Upper limb function: Ba Duan Jin ranked highest (SMD\u202f=\u202f1.33, 95% CI\u202f=\u202f0.80\u20131.86). (2) Lower limb function: Ba Duan Jin was the most effective (SMD\u202f=\u202f1.49, 95% CI\u202f=\u202f0.97\u20132.01). (3) Balance function: Wu Qin Xi demonstrated the best efficacy (SMD\u202f=\u202f1.56, 95% CI\u202f=\u202f0.45\u20132.67). (4) Activities of daily living: Wu Qin Xi was the top-ranked intervention (SMD\u202f=\u202f2.34, 95% CI\u202f=\u202f0.91\u20133.76). While Tai Ji and Yi Jin Jing were not the optimal choices, they still exhibited significant therapeutic benefits compared to conventional therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Traditional Chinese Medicine mind-body exercises significantly improve limb function and activities of daily living in stroke patients. Ba Duan Jin is recommended for upper and lower limb rehabilitation, while Wu Qin Xi is optimal for activities of daily living restoration and balance recovery. These findings provide clinicians with evidence-based guidance for selecting interventions tailored to specific functional deficits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>PROSPERO, identifier (CRD42025642353).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1759127","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T05:25:26Z","timestamp":1773379526000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Revealing mind-body interaction mechanisms: a network meta-analysis of the effects of traditional Chinese medicine mind-body exercise interventions on stroke rehabilitation"],"prefix":"10.3389","volume":"17","author":[{"given":"Zhenhui","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Physical Education, Shandong University","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianliang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Physical Education, Shandong University","place":["Jinan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"3435","DOI":"10.1007\/s10571-023-01396-8","article-title":"The role of progranulin (PGRN) in the pathogenesis of ischemic stroke","volume":"43","author":"Purrahman","year":"2023","journal-title":"Cell Mol Neurobiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/S1474-4422(21)00252-0","article-title":"Global, regional, and national burden of stroke and its risk factors, 1990\u20132019: a systematic analysis for the global burden of disease study 2019","volume":"20","author":"Feigin","year":"2021","journal-title":"Lancet Neurol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1590\/S1807-59322011001200008","article-title":"Abnormal sensory integration affects balance control in hemiparetic patients within the first year after stroke","volume":"66","author":"Oliveira","year":"2011","journal-title":"Clinics"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2532","DOI":"10.1161\/STR.0000000000000022","article-title":"Physical activity and exercise recommendations for stroke survivors a statement for healthcare professionals from the American heart association\/american stroke association","volume":"45","author":"Billinger","year":"2014","journal-title":"Stroke"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"i3857","DOI":"10.1136\/bmj.i3857","article-title":"Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta-analysis for the global burden of disease study 2013","volume":"354","author":"Kyu","year":"2016","journal-title":"BMJ"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"3556","DOI":"10.3390\/jcm11123556","article-title":"The effect of endurance training on serum BDNF levels in the chronic post-stroke phase: current evidence and qualitative systematic review","volume":"11","author":"Gorna","year":"2022","journal-title":"J Clin Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.neubiorev.2012.11.011","article-title":"Physical activity in the prevention of ischemic stroke and improvement of outcomes: a narrative review","volume":"37","author":"Middleton","year":"2013","journal-title":"Neurosci Biobehav Rev"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1001\/archinte.164.4.460-a","article-title":"Anti-inflammatory effect of physical activity","volume":"164","author":"Mascitelli","year":"2004","journal-title":"Arch Intern Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"CD003316","DOI":"10.1002\/14651858.CD003316.pub7","article-title":"Physical fitness training for stroke patients","volume":"3","author":"Saunders","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"9842104","DOI":"10.1155\/2022\/9842104","article-title":"Traditional Chinese exercise for chronic diseases","volume":"2022","author":"Wang","year":"2022","journal-title":"Evid Based Complement Altern Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"102912","DOI":"10.1016\/j.ctim.2022.102912","article-title":"Are movement-based mindful exercises (QIGONG, TAI CHI, AND YOGA) beneficial for stroke and parkinson\u2019s disease? 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